WormBase Tree Display for Gene: WBGene00003372
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| WBGene00003372 | SMap | S_parent | Sequence | CHROMOSOME_III | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | mlc-4 | Person_evidence | WBPerson21 | |||||
| Sequence_name | C56G7.1 | ||||||||
| Molecular_name | C56G7.1 | ||||||||
| C56G7.1.1 | |||||||||
| CE01531 | |||||||||
| Other_name | CELE_C56G7.1 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | mlc-4 | ||||||||
| DB_info | Database | AceView | gene | 3E482 | |||||
| WormQTL | gene | WBGene00003372 | |||||||
| WormFlux | gene | WBGene00003372 | |||||||
| NDB | locus_tag | CELE_C56G7.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003372|UniProtKB=Q09510 | |||||||
| family | PTHR23049 | ||||||||
| NCBI | gene | 175440 | |||||||
| RefSeq | protein | NM_065299.7 | |||||||
| SwissProt | UniProtAcc | Q09510 | |||||||
| UniProt_GCRP | UniProtAcc | Q09510 | |||||||
| OMIM | gene | 609905 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mlc | ||||||||
| Allele (45) | |||||||||
| Strain | WBStrain00026582 | ||||||||
| WBStrain00026583 | |||||||||
| WBStrain00007294 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (39) | |||||||||
| Paralog | WBGene00003369 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00003370 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | mlc-4 encodes, along with mlc-1 and mlc-2, one of three C. elegans regulatory myosin light chains; mlc-4 appears to encode the sole C. elegans regulatory light chain for nonmuscle myosin and during development, mlc-4 activity is required maternally for cytokinesis in meiosis and mitosis and for establishment of some aspects of anterior-posterior polarity in the early embryo; further, RNA interference studies show that two proteins, LET-502 (Rho-binding kinase) and MEL-11 (myosin phosphatase) do not properly localize at the cleavage furrow in mutant mlc-4 embryos during embryonic cytokinesis; later, zygotic mlc-4 activity is required for proper embryonic elongation and larval development; an MLC-4::GFP fusion protein that rescues the zygotic defects is expressed in the lateral hypodermal (seam) cells beginning at the bean stage of embryogenesis and continuing through larval stages; expression is also observed postembryonically in the spermathecal and uterine walls as well as weakly in the gonadal sheath and intestinal muscle. | Paper_evidence | WBPaper00003624 | |||||
| WBPaper00005318 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 04 Apr 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable myosin heavy chain binding activity. Involved in several processes, including cytoskeleton-dependent cytokinesis; embryonic body morphogenesis; and nematode larval development. Located in cytoplasm. Part of filamentous actin. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy and megacystis-microcolon-intestinal hypoperistalsis syndrome. Is an ortholog of human MYL9 (myosin light chain 9). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0080326 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15754) | ||||
| DOID:0060610 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:15754) | ||||||
| Molecular_info | Corresponding_CDS | C56G7.1 | |||||||
| Corresponding_transcript | C56G7.1.1 | ||||||||
| Other_sequence (68) | |||||||||
| Associated_feature | WBsf666635 | ||||||||
| WBsf666636 | |||||||||
| WBsf666637 | |||||||||
| WBsf226340 | |||||||||
| WBsf226341 | |||||||||
| Experimental_info | RNAi_result (18) | ||||||||
| Expr_pattern | Expr1028798 | ||||||||
| Expr1031551 | |||||||||
| Expr1147272 | |||||||||
| Expr2013592 | |||||||||
| Expr2031825 | |||||||||
| Drives_construct | WBCnstr00005730 | ||||||||
| WBCnstr00016035 | |||||||||
| WBCnstr00016036 | |||||||||
| WBCnstr00016095 | |||||||||
| Construct_product | WBCnstr00005730 | ||||||||
| WBCnstr00007515 | |||||||||
| WBCnstr00008110 | |||||||||
| WBCnstr00016035 | |||||||||
| WBCnstr00016036 | |||||||||
| WBCnstr00016095 | |||||||||
| WBCnstr00017282 | |||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (111) | |||||||||
| Interaction (57) | |||||||||
| WBProcess | WBbiopr:00000017 | ||||||||
| Map_info | Map | III | Position | -7.06064 | Error | 0.028904 | |||
| Positive | Positive_clone | C56G7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4491 | |||||||
| 5488 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (59) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
