WormBase Tree Display for Gene: WBGene00003058
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WBGene00003058 | SMap | S_parent | Sequence | CHROMOSOME_II | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | lov | ||||||
Allele (183) | |||||||
Strain | WBStrain00030878 | ||||||
WBStrain00030885 | |||||||
WBStrain00030886 | |||||||
WBStrain00031467 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (34) | |||||||
Ortholog (27) | |||||||
Paralog | WBGene00004035 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00016889 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | lov-1 encodes a transmembrane protein orthologous to human PKD1; lov-1 is required for two aspects of male mating behavior: response to hermaphrodite contact and vulva location and acts with PKD-2, a TRPP cation channel; LOV-1 is expressed in three types of male-specific neurons and localizes to the cell bodies and cilia; EGL-44 and EGL-46 regulate cell-specific expression of lov-1 and pkd-2 to specify the behavioral function of the HOB hook sensillum neuron; in vitro, LOV-1 interacts, via its conserved PLAT domain, with the N-terminus of ATP-2, the beta subunit of ATP synthase that also localizes to cilia, suggesting that ATP synthase may play a role in C. elegans polycystin signaling. | Paper_evidence | WBPaper00003680 | |||
WBPaper00004854 | |||||||
WBPaper00006247 | |||||||
WBPaper00024944 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 12 Aug 2011 00:00:00 | ||||||
Automated_description | Enables protein domain specific binding activity. Involved in response to hermaphrodite contact and vulval location. Located in neuronal cell body and non-motile cilium. Expressed in CEM and in male. Used to study autosomal dominant polycystic kidney disease. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:898 | Homo sapiens | Paper_evidence | WBPaper00003680 | ||
WBPaper00004854 | |||||||
Accession_evidence | OMIM | 173900 | |||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 30 Apr 2018 00:00:00 | ||||||
Disease_relevance | lov-1 and pkd-2 encode the orthologs of human Polycystin-1 and Polycystin-2, which are mutated in autosomal dominant polycystic kidney disease; the polycystins regulate signaling involved in normal renal tubular structure and function; studies in the worm C. elegans have contributed extensively to the finding that cystic kidney diseases can be considered ciliopathies; in elegans lov-1 and pkd-2 are expressed in male ciliary neurons, are required for normal male mating behavior, do not seem to be required for ciliogenesis, and each polycystin may actually have a potential inhibitory function on the other for ciliary function; lov-1 and pkd-1 interact with a single-pass transmembrane protein, CWP-5, though the significance of this interaction for polycystic kidney disease is unknown. | Homo sapiens | Paper_evidence | WBPaper00003680 | |||
Accession_evidence | OMIM | 601313 | |||||
173900 | |||||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 31 Jan 2013 00:00:00 | ||||||
Models_disease_asserted | WBDOannot00000024 | ||||||
WBDOannot00000512 | |||||||
WBDOannot00000515 | |||||||
WBDOannot00000516 | |||||||
Molecular_info | Corresponding_CDS | ZK945.9 | |||||
Corresponding_CDS_history (2) | |||||||
Corresponding_transcript | ZK945.9.1 | ||||||
Other_sequence | JI173898.1 | ||||||
JO470013.1 | |||||||
JO468300.1 | |||||||
JI164556.1 | |||||||
Associated_feature | WBsf989248 | ||||||
WBsf1012968 | |||||||
Experimental_info | RNAi_result (11) | ||||||
Expr_pattern | Expr1148 | ||||||
Expr3208 | |||||||
Expr11946 | |||||||
Expr1025218 | |||||||
Expr1163281 | |||||||
Expr2013249 | |||||||
Expr2031480 | |||||||
Drives_construct | WBCnstr00006717 | ||||||
WBCnstr00010107 | |||||||
WBCnstr00014864 | |||||||
WBCnstr00014875 | |||||||
WBCnstr00019759 | |||||||
WBCnstr00019881 | |||||||
WBCnstr00036257 | |||||||
Construct_product | WBCnstr00014869 | ||||||
WBCnstr00014875 | |||||||
WBCnstr00019759 | |||||||
WBCnstr00036257 | |||||||
Antibody | WBAntibody00002515 | ||||||
WBAntibody00002632 | |||||||
Microarray_results (22) | |||||||
Expression_cluster (64) | |||||||
Interaction (58) | |||||||
WBProcess | WBbiopr:00000012 | ||||||
Map_info | Map | II | Position | 1.90347 | Error | 0.014559 | |
Well_ordered | |||||||
Positive | Positive_clone | ZK945 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 3960 | |||||
3961 | |||||||
5093 | |||||||
Pos_neg_data | 10577 | ||||||
10578 | |||||||
10579 | |||||||
10580 | |||||||
10581 | |||||||
10582 | |||||||
Reference (101) | |||||||
Method | Gene |