WormBase Tree Display for Gene: WBGene00002978
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WBGene00002978 | SMap | S_parent | Sequence | Y105E8B | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | lev | ||||||
Reference_allele | WBVar00275207 | ||||||
Allele (206) | |||||||
Legacy_information | x12 : slightly long uncoordinated mild twitcher phenotype grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. NA3 (x1 : twitcher e1724 : lethal). | ||||||
See also e1724 | |||||||
[Williams BD] Pat (paralysed arrest at two-fold), severe paralysis; st577 and st566 have some pharyngeal pumping. | |||||||
[C.elegansII] x12 : slightly long, uncoordinated, mild twitcher phenotype; grows well in 1 mM levamisole; strong semi-dominant suppressor of unc-90(e1463). ES3 ME2. OA6: x1 (twitcher), e1724 (lethal). Also Pat (paralysed arrest at two-fold) alleles: st536 (severe paralysis),st577, st566 (some pharyngeal pumping. Greatly reduced staining for tropomyosin, probably corresponds to structural gene tmy-1. [Lewis et al. 1980; Williams and Waterston 1994; HK; ZZ]lfeLet-23 FErtility effector/regulator.PS. | |||||||
[C.elegansII] Probably corresponds to lev-11. Three transcripts encoding tropomyosin, probable body wall and non-muscle isoforms (284 aa,different C-termini) and pharyngeal isoform (256 aa, different promoter). [Kagawa et al. 1995; HK] | |||||||
Strain | WBStrain00002959 | ||||||
WBStrain00033515 | |||||||
WBStrain00033518 | |||||||
WBStrain00033524 | |||||||
WBStrain00040917 | |||||||
WBStrain00040918 | |||||||
WBStrain00004923 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (20) | |||||||
Ortholog (47) | |||||||
Structured_description | Concise_description | lev-11 encodes tropomyosin, an actin-binding contractile structural protein orthologous to human TROPOMYOSIN 1 (TPM1; OMIM:191010), which when mutated leads to familial hypertrophic cardiomyopathy; LEV-11 is required for embryonic development, normal body morphology, and locomotion; expressed as multiple tissue-specific isoforms generated by alternative mRNA splicing and promoter use, LEV-11 is detected in several tissues including muscle, pharynx, intestine, and the germ line. | Paper_evidence | WBPaper00002748 | |||
WBPaper00004944 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson1823 | |||||||
WBPerson567 | |||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Enables actin filament binding activity. Involved in several processes, including actin filament organization; regulation of actin polymerization or depolymerization; and spicule insertion. Located in striated muscle thin filament. Expressed in several structures, including body wall musculature; germ line; intestine; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); muscle tissue disease (multiple); and thyroid gland papillary carcinoma. Is an ortholog of several human genes including TPM1 (tropomyosin 1); TPM2 (tropomyosin 2); and TPM3 (tropomyosin 3). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (9) | ||||||
Molecular_info (5) | |||||||
Experimental_info | RNAi_result (31) | ||||||
Expr_pattern (15) | |||||||
Drives_construct (12) | |||||||
Construct_product | WBCnstr00010369 | ||||||
WBCnstr00012505 | |||||||
WBCnstr00016244 | |||||||
WBCnstr00041176 | |||||||
Antibody | WBAntibody00000099 | ||||||
WBAntibody00000422 | |||||||
WBAntibody00000423 | |||||||
WBAntibody00000472 | |||||||
Microarray_results (61) | |||||||
Expression_cluster (304) | |||||||
Interaction (175) | |||||||
WBProcess | WBbiopr:00000006 | ||||||
Map_info | Map | I | Position | 25.8125 | Error | 0.018971 | |
Well_ordered | |||||||
Positive | Positive_clone | Y105E8B | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | 2_point | 209 | |||||
213 | |||||||
214 | |||||||
327 | |||||||
5106 | |||||||
6076 | |||||||
Multi_point (11) | |||||||
Pos_neg_data (13) | |||||||
Reference (90) | |||||||
Remark | Data extracted from Williams & Waterston 1994 | ||||||
The gene tmy-1 was merged into this gene by krb on advice of JAH 25/02/02 | |||||||
Method | Gene |