WormBase Tree Display for Gene: WBGene00002275
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WBGene00002275 | Evidence | Paper_evidence | WBPaper00004339 | ||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | CHROMOSOME_II | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | lem | ||||||
Allele (91) | |||||||
Possibly_affected_by | WBVar02153030 | ||||||
Strain (3) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (28) | |||||||
Contained_in_operon | CEOP2724 | ||||||
Ortholog (26) | |||||||
Structured_description | Concise_description | lem-2 encodes the ortholog of the vertebrate LEM2 and MAN1 proteins and contains a LEM domain which is a defining 40 amino acid motif shared by a family of nuclear envelope proteins; LEM family proteins bind to lamins and to the small inner nuclear membrane associated protein BAF; LEM-2 provides an anchor by which chromosomes are attached to the nuclear membrane; lem-2 together with the LEM domain protein emr-1/emerin, bind lmn-1/lamin and are required for viability and proper chromosome segregation; LEM-2 localizes to the nuclear membrane; lem-2 mutations also exhibit moderate hypersensitivity to DNA damage. | Paper_evidence | WBPaper00005828 | |||
WBPaper00037942 | |||||||
WBPaper00040826 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson324 | |||||||
Date_last_updated | 12 Apr 2012 00:00:00 | ||||||
Automated_description | Enables chromatin DNA binding activity and lamin binding activity. Involved in several processes, including mitotic cytokinesis; organelle organization; and response to X-ray. Located in chromosome and nuclear envelope. Used to study Emery-Dreifuss muscular dystrophy and cataract 46 juvenile-onset. Human ortholog(s) of this gene implicated in Buschke-Ollendorff syndrome and cataract 46 juvenile-onset. Is an ortholog of human LEMD2 (LEM domain nuclear envelope protein 2) and LEMD3 (LEM domain containing 3). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info (3) | |||||||
Models_disease_asserted | WBDOannot00000047 | ||||||
WBDOannot00000768 | |||||||
WBDOannot00000769 | |||||||
WBDOannot00000770 | |||||||
WBDOannot00000771 | |||||||
Molecular_info | Corresponding_CDS | W01G7.5 | |||||
Corresponding_transcript | W01G7.5.1 | ||||||
Other_sequence (19) | |||||||
Associated_feature | WBsf644830 | ||||||
WBsf658388 | |||||||
WBsf976399 | |||||||
WBsf976400 | |||||||
WBsf981354 | |||||||
WBsf990618 | |||||||
WBsf1013767 | |||||||
WBsf222419 | |||||||
WBsf222420 | |||||||
WBsf222421 | |||||||
Experimental_info | RNAi_result (15) | ||||||
Expr_pattern | Expr9180 | ||||||
Expr10879 | |||||||
Expr11504 | |||||||
Expr12212 | |||||||
Expr1014258 | |||||||
Expr1031341 | |||||||
Expr1158080 | |||||||
Expr2013044 | |||||||
Expr2031276 | |||||||
Drives_construct | WBCnstr00018933 | ||||||
WBCnstr00020602 | |||||||
Construct_product | WBCnstr00001838 | ||||||
WBCnstr00017548 | |||||||
WBCnstr00018933 | |||||||
WBCnstr00020602 | |||||||
Regulate_expr_cluster | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated | ||||||
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated | |||||||
WBPaper00044786:lem-2(tm1582)_downregulated | |||||||
WBPaper00044786:lem-2(tm1582)_upregulated | |||||||
Antibody | WBAntibody00000308 | ||||||
WBAntibody00000309 | |||||||
WBAntibody00000310 | |||||||
WBAntibody00000311 | |||||||
WBAntibody00001855 | |||||||
WBAntibody00002216 | |||||||
WBAntibody00002346 | |||||||
Microarray_results (22) | |||||||
Expression_cluster (158) | |||||||
Interaction (35) | |||||||
Map_info | Map | II | Position | 22.3934 | Error | 0.004999 | |
Positive | Positive_clone | W01G7 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 4984 | |||||
4388 | |||||||
Pseudo_map_position | |||||||
Reference (43) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |