WormBase Tree Display for Gene: WBGene00001650
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WBGene00001650 | SMap | S_parent | Sequence | CHROMOSOME_IV | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | gon | ||||||
Allele (221) | |||||||
Legacy_information | [C.elegansII] e1254 : defective formation of somatic gonad primordium; much germ line proliferation, almost no gamete maturation, variable vulval induction, no uterus. e1254/Df similar.ES3. ME0 (male somatic gonad also abnormal). OA4:e2547, e2551, q517, q518 (similar). [Hodgkin et al. 1989; CB; JK] | ||||||
Strain | WBStrain00022578 | ||||||
WBStrain00022613 | |||||||
WBStrain00004564 | |||||||
WBStrain00050795 | |||||||
WBStrain00054932 | |||||||
WBStrain00054931 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (30) | |||||||
Ortholog (56) | |||||||
Paralog | WBGene00000082 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00000083 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00086562 | Caenorhabditis elegans | From_analysis | Panther | ||||
WBGene00003242 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00009958 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00020567 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00021171 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00003248 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | gon-1 encodes a functional metalloprotease that defines a new sub-family of secreted proteases known as MPT (metalloprotease with thrombospondin type 1 repeats); the other two members of this family are the bovine procollagen I N-protease ( PINP ) and the murine enzyme ADAMTS-1; gon-1 is essential for hermaphrodite gonadal morphogenesis and sequence homology with other metalloproteases suggests that it functions by remodeling the extracellular matrix; gon-1 is also required for protein transport from the endoplasmic reticulum (ER) to the Golgi, a function dependent on its C-terminal GON domain; GON-1 is expressed at high levels within the gonadal distal tip cell during migration and also in body wall muscle cells; in the distal tip cell, reporter fusion constructs expressing the GON domain localize to the endoplasmic reticulum, suggesting that GON-1 functions both intra- and extracellularly. | Paper_evidence | WBPaper00003556 | |||
WBPaper00003841 | |||||||
WBPaper00040883 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson324 | |||||||
Date_last_updated | 16 Mar 2012 00:00:00 | ||||||
Automated_description | Enables metallopeptidase activity. Involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; muscle organ morphogenesis; and negative regulation of presynapse assembly. Predicted to be located in extracellular matrix. Expressed in amphid neurons; excretory cell; gonad; motor neurons; and muscle cell. Used to study obesity and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Is an ortholog of human ADAMTS20 (ADAM metallopeptidase with thrombospondin type 1 motif 20) and ADAMTS9 (ADAM metallopeptidase with thrombospondin type 1 motif 9). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Experimental_model | DOID:9352 | Homo sapiens | Paper_evidence | WBPaper00048391 | ||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 28 Oct 2015 00:00:00 | ||||||
DOID:9970 | Homo sapiens | Paper_evidence | WBPaper00061889 | ||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 28 Jun 2022 00:00:00 | ||||||
Potential_model | DOID:7148 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:220) | |||
Models_disease_in_annotation | WBDOannot00000381 | ||||||
WBDOannot00001255 | |||||||
Molecular_info | Corresponding_CDS | F25H8.3a | |||||
F25H8.3b | |||||||
Corresponding_CDS_history | F25H8.3:wp191 | ||||||
Corresponding_transcript | F25H8.3c | ||||||
F25H8.3a.1 | |||||||
F25H8.3a.2 | |||||||
F25H8.3b.1 | |||||||
Other_sequence | JI164015.1 | ||||||
Dviv_isotig32909 | |||||||
MP00069 | |||||||
CBC09661_1 | |||||||
Dviv_isotig16135 | |||||||
Oden_isotig19638 | |||||||
Hbac_isotig07485 | |||||||
Associated_feature (17) | |||||||
Experimental_info | RNAi_result (23) | ||||||
Expr_pattern (11) | |||||||
Drives_construct | WBCnstr00003119 | ||||||
WBCnstr00010223 | |||||||
WBCnstr00021147 | |||||||
WBCnstr00021148 | |||||||
WBCnstr00036796 | |||||||
Construct_product | WBCnstr00016199 | ||||||
WBCnstr00020015 | |||||||
WBCnstr00036796 | |||||||
Microarray_results (23) | |||||||
Expression_cluster (151) | |||||||
Interaction (36) | |||||||
Map_info | Map | IV | Position | 4.4533 | Error | 0.0006 | |
Well_ordered | |||||||
Positive | Positive_clone | F25H8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 1611 | |||||
3732 | |||||||
3733 | |||||||
3734 | |||||||
Pos_neg_data | 4643 | ||||||
4644 | |||||||
Reference (59) | |||||||
Method | Gene |