WormBase Tree Display for Gene: WBGene00003248

WBGene00003248 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: F57B7
  Identity: Version: 1
    Name: CGC_name: mig-17 Person_evidence: WBPerson261
      Sequence_name: F57B7.4
      Molecular_name: F57B7.4
        F57B7.4.1
        CE31010
      Other_name: CELE_F57B7.4 Accession_evidence: NDB BX284605
      Public_name: mig-17
    DB_info: Database: AceView gene 5L929
        WormQTL gene WBGene00003248
        WormFlux gene WBGene00003248
        NDB locus_tag CELE_F57B7.4
        NCBI gene 179575
        RefSeq protein NM_073500.8
        KEGG KEGG_id 3.4.24.-
        NemaPath KEGG_id 3.4.24.-
        SwissProt UniProtAcc Q20930
        UniProt_GCRP UniProtAcc Q20930
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:31 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mig
    Allele (38)
    Legacy_information: [Nishiwaki K ] DTC migration abnormal
    Strain: WBStrain00028694
      WBStrain00028701
      WBStrain00050676
    RNASeq_FPKM (74)
    GO_annotation (40)
    Ortholog (26)
    Paralog: WBGene00000082 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000083 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00001650 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00003242 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00009958 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00020567 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00021171 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: mig-17 encodes a secreted metalloprotease that is a member of the ADAM (A Disintegrin And Metalloprotease) protein family; MIG-17 activity is required for proper migration of gonadal leader cells, namely the hermaphrodite distal tip cells (DTCs) and the male linker cell (MLC); a MIG-17::GFP translational fusion protein is first detected in late embryos with expression continuing through adulthood; expression is initially seen on the pseudocoelomic face of body wall muscles and then on the surface of the gonad, when the DTCs migrate on the lateral hypodermis towards the dorsal muscles; proper MIG-17 localization and glycosylation requires activity of MIG-23, a membrane-bound nucleoside diphosphatase, as well as activity of COGC-3 and COGC-1, two members of the conserved oligomeric Golgi complex; expression studies with MIG-17 deletion derivatives indicate that MIG-17 is expressed by the body wall muscles and then localizes to the DTCs where its activity is sufficient for guiding DTC migration. Paper_evidence: WBPaper00004167
            WBPaper00006309
            WBPaper00026979
          Curator_confirmed: WBPerson1843
          Date_last_updated: 14 May 2007 00:00:00
      Automated_description: Enables metallopeptidase activity. Involved in several processes, including gonad morphogenesis; protein processing; and regulation of distal tip cell migration. Located in basement membrane and extracellular space. Expressed in several structures, including body wall musculature; gonad; head; intestine; and ventral nerve cord. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F57B7.4
    Corresponding_CDS_history: F57B7.4:wp51
      F57B7.4:wp80
    Corresponding_transcript: F57B7.4.1
    Other_sequence: AB044562
      CBC08395_1
    Associated_feature: WBsf647263
      WBsf661722
      WBsf1001353
      WBsf1001354
      WBsf1020450
      WBsf232506
  Experimental_info: RNAi_result: WBRNAi00015876 Inferred_automatically: RNAi_primary
      WBRNAi00089090 Inferred_automatically: RNAi_primary
      WBRNAi00110308 Inferred_automatically: RNAi_primary
      WBRNAi00048830 Inferred_automatically: RNAi_primary
      WBRNAi00000262 Inferred_automatically: RNAi_primary
    Expr_pattern (14)
    Drives_construct: WBCnstr00010039
      WBCnstr00010040
      WBCnstr00012154
      WBCnstr00012352
      WBCnstr00018816
      WBCnstr00036162
      WBCnstr00041881
    Construct_product: WBCnstr00010039
      WBCnstr00012154
      WBCnstr00018816
      WBCnstr00019731
      WBCnstr00036162
    Antibody: WBAntibody00001254
      WBAntibody00001441
    Microarray_results (18)
    Expression_cluster (131)
    Interaction (24)
  Map_info: Map: V Position: 3.10659 Error: 0.003887
    Positive: Positive_clone: F57B7 Person_evidence: WBPerson449
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4255
        4490
    Pseudo_map_position
  Reference (55)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene