WormBase Tree Display for Gene: WBGene00000898
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WBGene00000898 | SMap | S_parent | Sequence | Y55D5A | ||
---|---|---|---|---|---|---|
Identity (6) | ||||||
Gene_info (12) | ||||||
Disease_info | Experimental_model | DOID:9351 | Homo sapiens | Paper_evidence | WBPaper00064218 | |
Curator_confirmed | WBPerson324 | |||||
Date_last_updated | 07 Nov 2022 00:00:00 | |||||
DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00045313 | |||
Curator_confirmed | WBPerson324 | |||||
Date_last_updated | 26 Jan 2015 00:00:00 | |||||
Potential_model (37) | ||||||
Disease_relevance | Parkinson''s disease (PD) is an age-dependent neurodegenerative disease characterized by the accumulation of alpha-synuclein (alpha-syn) and the selective loss of dopamine (DA) neurons; studies in C. elegans models of alpha-syn proteotoxcity indicate that reduced IGF-1/insulin-like signaling (IIS) suppresses alpha-syn toxicity and DA neurodegeneration; specifically daf-2 mutant worms that overexpress human alpha-syn retain more wild-type DA neurons when compared to alpha-syn worms alone; mutants of daf-16/FOXO, a well-characterized downstream component of the IIS pathway enhanced neurodegeneration, and an intermediate level of neuroprotection was seen in daf-2; daf-16 double mutants overexpressing alpha-syn-GFP in DA neurons; further, RNA interference of glucose-6-phosphate isomerase (gpi-1/GPI), the glycolytic enzyme, enhanced alpha-syn-induced DA neurotoxicity, while it''s overexpression in DA neurons was neuroprotective; further studies in Drosophila and mice confirm that GPI is neuroprotective; these studies indicate that IIS signaling modulates alpha-syn induced DA neurodegeneration, across species. | Homo sapiens | Paper_evidence | WBPaper00045313 | ||
WBPaper00025083 | ||||||
WBPaper00031384 | ||||||
Curator_confirmed | WBPerson324 | |||||
Date_last_updated | 26 Jan 2015 00:00:00 | |||||
In glucose-fed wild-type animals, the exponential like decline was restored in the active state, indicating that insulin signaling may be involved in regulation of fractal scaling of C. elegans behavior. | Homo sapiens | Curator_confirmed | WBPerson324 | |||
Models_disease_in_annotation | WBDOannot00000339 | |||||
Models_disease_asserted | WBDOannot00001356 | |||||
Molecular_info | Corresponding_CDS | Y55D5A.5a | ||||
Y55D5A.5c | ||||||
Y55D5A.5d | ||||||
Y55D5A.5e | ||||||
Y55D5A.5f | ||||||
Y55D5A.5g | ||||||
Corresponding_CDS_history (4) | ||||||
Corresponding_transcript | Y55D5A.5b | |||||
Y55D5A.5a.1 | ||||||
Y55D5A.5c.1 | ||||||
Y55D5A.5d.1 | ||||||
Y55D5A.5e.1 | ||||||
Y55D5A.5f.1 | ||||||
Y55D5A.5g.1 | ||||||
Other_sequence (112) | ||||||
Associated_feature (24) | ||||||
Experimental_info (11) | ||||||
Map_info (5) | ||||||
Reference (1726) | ||||||
Picture | WBPicture0000013078 | |||||
WBPicture0000013087 | ||||||
Method | Gene |