WormBase Tree Display for Gene: WBGene00001402

WBGene00001402 SMap: S_parent: Sequence: F21H12
  Identity: Version: 1
    Name: CGC_name: fbf-2 Person_evidence: WBPerson320
      Sequence_name: F21H12.5
      Molecular_name: F21H12.5
        F21H12.5.1
        CE01916
      Other_name (3)
      Public_name: fbf-2
    DB_info: Database: AceView gene 2G380
        WormQTL gene WBGene00001402
        WormFlux gene WBGene00001402
        NDB locus_tag CELE_F21H12.5
        Panther gene CAEEL|WormBase=WBGene00001402|UniProtKB=Q09312
          family PTHR12537
        NCBI gene 174017
        RefSeq protein NM_001381445.2
        SwissProt UniProtAcc Q09312
        TREEFAM TREEFAM_ID TF318622
        UniProt_GCRP UniProtAcc Q09312
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:24 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: fbf
    Allele (52)
    Legacy_information: [Gallegos M, Zhang B] fbf-2(RNAi) animals produce excess sperm and no oocytes (Mog phenotype). Encodes fem-3 PME RNA binding protein, 91% identical to FBF-1. Predicted gene F21H12.5
    Strain: WBStrain00022611
      WBStrain00022612
      WBStrain00022628
      WBStrain00022640
      WBStrain00022665
      WBStrain00022345
      WBStrain00022394
      WBStrain00022449
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog (33)
    Paralog: WBGene00001401 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00004239 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00022257 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00004241 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00004243 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00004242 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00004240 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
      WBGene00004244 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004245 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: fbf-2 encodes an RNA-binding protein that is one of 11 C. elegans members of the PUF family (Pumilio and FBF) of translational regulators; FBF-2 is nearly identical to FBF-1 with which it is largely redundant in regulating two aspects of germline development: 1)maintenance of stem cell proliferation, and 2)the hermaphroditic switch between spermatogenesis and oogenesis; in maintaining germline stem cells, the FBF proteins, acting through NOS-3, negatively regulate the activity of gld-1 mRNA, which encodes a translational repressor required for meiotic entry; in regulating the sperm-to-oocyte switch, the FBFs act downstream of GLD-3 to negatively regulate the activity of fem-3 mRNA, which encodes a novel protein required for germline sex determination; consistent with their role in germline development, FBF-1 and FBF-2 are expressed in the germline cytoplasm, becoming enriched in the mitotic region during the L4 larval and adult stages. Paper_evidence: WBPaper00002949
            WBPaper00005265
            WBPaper00005566
            WBPaper00006369
            WBPaper00018711
          Curator_confirmed: WBPerson1843
          Date_last_updated: 24 Sep 2004 00:00:00
      Automated_description: Enables mRNA 3'-UTR binding activity. Involved in negative regulation of translation. Located in P granule. Used to study obesity. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:9970 Homo sapiens Paper_evidence: WBPaper00061889
          Curator_confirmed: WBPerson324
          Date_last_updated: 28 Jun 2022 00:00:00
  Models_disease_in_annotation: WBDOannot00001264
  Molecular_info: Corresponding_CDS: F21H12.5
    Corresponding_transcript: F21H12.5.1
    Other_sequence: EX544358.1
      Oden_isotig19477
      PP02603
      PPC01861_1
      EX564883.1
      GW916430.1
      CJC02888_1
    Associated_feature: WBsf223129
    Gene_product_binds: WBsf027922
      WBsf899551
      WBsf899552
      WBsf899553
      WBsf899554
    Transcription_factor: WBTranscriptionFactor000103
  Experimental_info: RNAi_result (70)
    Expr_pattern (12)
    Drives_construct: WBCnstr00005290
      WBCnstr00036968
    Construct_product: WBCnstr00005274
      WBCnstr00015117
      WBCnstr00036968
      WBCnstr00040359
    Regulate_expr_cluster: WBPaper00055804:FBF-1-FBF-2-associated_oogenic-enriched
      WBPaper00055804:FBF-1-FBF-2-associated_spermatogenic-enriched
    Antibody (3)
    Microarray_results (16)
    Expression_cluster (117)
    Interaction (93)
  Map_info: Map: II Position: -0.523905 Error: 0.013695
    Positive: Positive_clone: F21H12 Author_evidence: (genome sequence,
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4304
        4305
        4907
    Pseudo_map_position
  Reference: WBPaper00002949
    WBPaper00003026
    WBPaper00003047
    WBPaper00003410
    WBPaper00003762
    WBPaper00003933
    WBPaper00003990
    WBPaper00004256
    WBPaper00004349
    WBPaper00004549
    WBPaper00005265
    WBPaper00005338
    WBPaper00005566
    WBPaper00006073
    WBPaper00006101
    WBPaper00006369
    WBPaper00006404
    WBPaper00010105
    WBPaper00010135
    WBPaper00010729
    WBPaper00012309
    WBPaper00012347
    WBPaper00012455
    WBPaper00012973
    WBPaper00017836
    WBPaper00018387
    WBPaper00018711
    WBPaper00018721
    WBPaper00018734
    WBPaper00018890
    WBPaper00023240
    WBPaper00024263
    WBPaper00024312
    WBPaper00024563
    WBPaper00025000
    WBPaper00025029
    WBPaper00025264
    WBPaper00025899
    WBPaper00026645
    WBPaper00026678
    WBPaper00026891
    WBPaper00026919
    WBPaper00026961
    WBPaper00027025
    WBPaper00027224
    WBPaper00027248
    WBPaper00027252
    WBPaper00027261
    WBPaper00027294
    WBPaper00027310
    WBPaper00027354
    WBPaper00027472
    WBPaper00027613
    WBPaper00027724
    WBPaper00027802
    WBPaper00027808
    WBPaper00027949
    WBPaper00028346
    WBPaper00029084
    WBPaper00029255
    WBPaper00030414
    WBPaper00031318
    WBPaper00031367
    WBPaper00031972
    WBPaper00032220
    WBPaper00032912
    WBPaper00033036
    WBPaper00033153
    WBPaper00033205
    WBPaper00034810
    WBPaper00035905
    WBPaper00036206
    WBPaper00038281
    WBPaper00038491
    WBPaper00039615
    WBPaper00040043
    WBPaper00040556
    WBPaper00040600
    WBPaper00040660
    WBPaper00040859
    WBPaper00040947
    WBPaper00040968
    WBPaper00041018
    WBPaper00041299
    WBPaper00041558
    WBPaper00043781
    WBPaper00043786
    WBPaper00043978
    WBPaper00045173
    WBPaper00045597
    WBPaper00048212
    WBPaper00048234
    WBPaper00048250
    WBPaper00048260
    WBPaper00048418
    WBPaper00048471
    WBPaper00048543
    WBPaper00048917
    WBPaper00049573
    WBPaper00049828
    WBPaper00050447
    WBPaper00051955
    WBPaper00052139
    WBPaper00052140
    WBPaper00052170
    WBPaper00052344
    WBPaper00052353
    WBPaper00052872
    WBPaper00053101
    WBPaper00053452
    WBPaper00053705
    WBPaper00055090
    WBPaper00055915
    WBPaper00056062
    WBPaper00057150
    WBPaper00057340
    WBPaper00057735
    WBPaper00057889
    WBPaper00058909
    WBPaper00059332
    WBPaper00059392
    WBPaper00059440
    WBPaper00060099
    WBPaper00060545
    WBPaper00061889
    WBPaper00061898
    WBPaper00062336
    WBPaper00062842
    WBPaper00063100
    WBPaper00063217
    WBPaper00063220
    WBPaper00063223
    WBPaper00063322
    WBPaper00065284
    WBPaper00066042
    WBPaper00066170
  Picture: WBPicture0000013095
  Remark: Data extracted from Zhang et al. (1997)
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene