WormBase Tree Display for Gene: WBGene00000939

WBGene00000939 Evidence: Paper_evidence: WBPaper00004772
  SMap: S_parent: Sequence: K12H4
  Identity: Version: 1
    Name: CGC_name: dcr-1 Person_evidence: WBPerson419
      Sequence_name: K12H4.8
      Molecular_name: K12H4.8
        K12H4.8.1
        CE47418
      Other_name: let-740 CGC_data_submission
        eri-4 Paper_evidence: WBPaper00035199
        CELE_K12H4.8 Accession_evidence: NDB BX284603
      Public_name: dcr-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:22 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: dcr
    Allele (78)
    Legacy_information: Homozygous s2624 and s2795 each develope into sterile adults.
    Strain (13)
    RNASeq_FPKM (74)
    GO_annotation (61)
    Ortholog (58)
    Paralog: WBGene00001090 Caenorhabditis elegans From_analysis: TreeFam
      WBGene00008400 Caenorhabditis elegans From_analysis: TreeFam
    Structured_description: Concise_description: dcr-1 encodes a bidentate ribonuclease that is homologous to E. coli RNAse III; DCR-1 is required both for RNA interference and for synthesis of small developmental RNAs; DCR-1 functions to process pre-miRNAs into their mature, 22-nt form; DCR-1 interacts in vivo with RDE-4, a double-stranded RNA (dsRNA) binding protein required for RNAi that interacts with trigger dsRNAs and may function to deliver dsRNAs to DCR-1 for endonucleolytic processing; DCR-1 is also required for fragmention of chromosomal DNA during apoptosis, and undergoes a CED-3 protease-mediated conversion from a ribonuclease to a deoxyribonuclease. Paper_evidence: WBPaper00004424
            WBPaper00004923
            WBPaper00005368
            WBPaper00036025
            WBPaper00024573
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 03 Feb 2014 00:00:00
      Automated_description: Enables deoxyribonuclease I activity and ribonuclease III activity. Involved in several processes, including nucleic acid metabolic process; olfactory learning; and positive regulation of primary miRNA processing. Acts upstream of or within defense response to Gram-positive bacterium. Located in cytosol and nucleus. Expressed in germ line; intestine; neurons; and somatic cell. Human ortholog(s) of this gene implicated in several diseases, including DICER1 syndrome; gastrointestinal system cancer (multiple); and multinodular goiter. Is an ortholog of human DICER1 (dicer 1, ribonuclease III). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17098)
      DOID:4769 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17098)
      DOID:0050745 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17098)
      DOID:0080615 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17098)
      DOID:0050489 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17098)
      DOID:10534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17098)
      DOID:0081063 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17098)
      DOID:684 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17098)
  Molecular_info: Corresponding_CDS: K12H4.8
    Corresponding_CDS_history: K12H4.8:wp230
    Corresponding_transcript: K12H4.8.1
    Other_sequence (58)
    Associated_feature: WBsf651241
      WBsf667129
      WBsf227077
      WBsf227078
  Experimental_info: RNAi_result (65)
    Expr_pattern: Expr10581
      Expr11565
      Expr12215
      Expr12472
      Expr1022725
      Expr1030586
      Expr1154395
      Expr2010807
      Expr2029044
    Drives_construct: WBCnstr00005999
      WBCnstr00006000
      WBCnstr00006001
      WBCnstr00017007
      WBCnstr00020414
      WBCnstr00037186
    Construct_product (13)
    Regulate_expr_cluster: WBPaper00027057:DCR-1_interacting_adult
      WBPaper00027057:DCR-1_interacting_embryo
      WBPaper00029437:dcr-1_downregulated
      WBPaper00029437:dcr-1_upregulated
      WBPaper00059490:dcr-1(m9375)_downregulated
      WBPaper00059490:dcr-1(m9375)_upregulated
    Antibody: WBAntibody00000418
      WBAntibody00001054
      WBAntibody00001326
      WBAntibody00001327
      WBAntibody00001490
      WBAntibody00002257
      WBAntibody00002600
    Microarray_results (18)
    Expression_cluster (137)
    Interaction (219)
    WBProcess: WBbiopr:00000014
      WBbiopr:00000039
      WBbiopr:00000057
      WBbiopr:00000073
      WBbiopr:00000081
  Map_info: Map: III Position: -0.385999 Error: 0.003601
    Hide_under: WBGene00002843
    Positive: Inside_rearr: nDf20
        sDp3
        sDp8
      Positive_clone: K12H4 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Outside_rearr: sDf128
    Mapping_data (2)
  Reference: WBPaper00003304
    WBPaper00004772
    WBPaper00004870
    WBPaper00004923
    WBPaper00004928
    WBPaper00005193
    WBPaper00005368
    WBPaper00005488
    WBPaper00005601
    WBPaper00005624
    WBPaper00005667
    WBPaper00005825
    WBPaper00005932
    WBPaper00006077
    WBPaper00006308
    WBPaper00010381
    WBPaper00010663
    WBPaper00010804
    WBPaper00017730
    WBPaper00017895
    WBPaper00019502
    WBPaper00023918
    WBPaper00024202
    WBPaper00024225
    WBPaper00024434
    WBPaper00024516
    WBPaper00024573
    WBPaper00025011
    WBPaper00025208
    WBPaper00025457
    WBPaper00025582
    WBPaper00025632
    WBPaper00025700
    WBPaper00026198
    WBPaper00026221
    WBPaper00026381
    WBPaper00026396
    WBPaper00026593
    WBPaper00026665
    WBPaper00026707
    WBPaper00026940
    WBPaper00026973
    WBPaper00027057
    WBPaper00027111
    WBPaper00027135
    WBPaper00027224
    WBPaper00027282
    WBPaper00027312
    WBPaper00027634
    WBPaper00027766
    WBPaper00028406
    WBPaper00028417
    WBPaper00028885
    WBPaper00029211
    WBPaper00029328
    WBPaper00029437
    WBPaper00031031
    WBPaper00031214
    WBPaper00031224
    WBPaper00031747
    WBPaper00031961
    WBPaper00031962
    WBPaper00032126
    WBPaper00032169
    WBPaper00032178
    WBPaper00032458
    WBPaper00032961
    WBPaper00034371
    WBPaper00034554
    WBPaper00034573
    WBPaper00034895
    WBPaper00035168
    WBPaper00035199
    WBPaper00035245
    WBPaper00035324
    WBPaper00035889
    WBPaper00036025
    WBPaper00036080
    WBPaper00036290
    WBPaper00037401
    WBPaper00037884
    WBPaper00038491
    WBPaper00038898
    WBPaper00039129
    WBPaper00040276
    WBPaper00040558
    WBPaper00040849
    WBPaper00041520
    WBPaper00042320
    WBPaper00042343
    WBPaper00042974
    WBPaper00043420
    WBPaper00043726
    WBPaper00043989
    WBPaper00044013
    WBPaper00044032
    WBPaper00044120
    WBPaper00044498
    WBPaper00044574
    WBPaper00046042
    WBPaper00046118
    WBPaper00046160
    WBPaper00046432
    WBPaper00047243
    WBPaper00047259
    WBPaper00050743
    WBPaper00051984
    WBPaper00052461
    WBPaper00054282
    WBPaper00055090
    WBPaper00060692
    WBPaper00060750
    WBPaper00061061
    WBPaper00061133
    WBPaper00062457
    WBPaper00062465
    WBPaper00062532
    WBPaper00063510
    WBPaper00063541
    WBPaper00063609
    WBPaper00064666
    WBPaper00064728
    WBPaper00064771
    WBPaper00066313
  Remark: The let-740 gene is the same gene as dcr-1 and they therefore have been merged following advice from the CGC. let-740 is now an other name for dcr-1 [krb 030508]
  Method: Gene