WormBase Tree Display for Gene: WBGene00018771
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WBGene00018771 | SMap | S_parent | Sequence | F53G12 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | duox-2 | Paper_evidence | WBPaper00004841 | |||
Person_evidence | WBPerson56 | ||||||
Sequence_name | F53G12.3 | ||||||
Molecular_name | F53G12.3 | ||||||
F53G12.3.1 | |||||||
CE24999 | |||||||
Other_name | CELE_F53G12.3 | Accession_evidence | NDB | BX284601 | |||
Public_name | duox-2 | ||||||
DB_info | Database (13) | ||||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | duox | ||||||
Allele (99) | |||||||
Strain | WBStrain00005177 | ||||||
WBStrain00032202 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (18) | |||||||
Ortholog (44) | |||||||
Paralog | WBGene00000253 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Inparanoid_8 | |||||||
Panther | |||||||
WormBase-Compara | |||||||
Structured_description | Concise_description | duox-2 encodes a large partial homolog of dual oxidase, with an N-terminal peroxidase domain, two central calmodulin-binding EF hands, and a C-terminal superoxide-generating NADPH-oxidase domain; duox-2 may be required for dityrosine cross-linking of collagen, and thus for cuticular integrity; duox-2 may use cytosolic NADPH to generate reactive oxygen, which then may drive the peroxidase ectodomain to cross-link free tyrosine in collagen; DUOX-2 has no visible expression pattern detectable by antibodies, implying very low or rare expression. | Paper_evidence | WBPaper00004841 | |||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 09 Sep 2009 00:00:00 | ||||||
Automated_description | Predicted to enable superoxide-generating NAD(P)H oxidase activity. Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle and post-embryonic body morphogenesis. Predicted to be located in plasma membrane. Predicted to be part of NADPH oxidase complex. Human ortholog(s) of this gene implicated in cholera; inflammatory bowel disease (multiple); and thyroid dyshormonogenesis 6. Is an ortholog of human DUOX2 (dual oxidase 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0050328 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13273) | ||
DOID:8577 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13273) | ||||
DOID:1498 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13273) | ||||
DOID:8778 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13273) | ||||
DOID:0112189 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13273) | ||||
Molecular_info | Corresponding_CDS | F53G12.3 | |||||
Corresponding_transcript | F53G12.3.1 | ||||||
Other_sequence (19) | |||||||
Associated_feature | WBsf982411 | ||||||
WBsf1009035 | |||||||
Experimental_info | RNAi_result | WBRNAi00082862 | Inferred_automatically | RNAi_primary | |||
WBRNAi00097074 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00025701 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00095096 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00097063 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00095097 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00048168 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00003808 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00025700 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00065022 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00090928 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00097075 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00097073 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00097064 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00082857 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00025597 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00097066 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00070598 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00097065 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00097061 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00095098 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00095095 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00066795 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00081639 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00070600 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00097076 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00097062 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00025598 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00003755 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr1010521 | ||||||
Expr1038089 | |||||||
Expr1151983 | |||||||
Expr2011116 | |||||||
Expr2029352 | |||||||
Drives_construct | WBCnstr00026282 | ||||||
Construct_product | WBCnstr00026282 | ||||||
Microarray_results (21) | |||||||
Expression_cluster (78) | |||||||
SAGE_tag (11) | |||||||
Interaction (22) | |||||||
Map_info | Map | I | Position | -19.1584 | Error | 0.002786 | |
Positive | Positive_clone | F53G12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference | WBPaper00004841 | ||||||
WBPaper00005747 | |||||||
WBPaper00038491 | |||||||
WBPaper00041408 | |||||||
WBPaper00055090 | |||||||
WBPaper00055350 | |||||||
WBPaper00059817 | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |