WormBase Tree Display for Gene: WBGene00004764
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WBGene00004764 | Evidence | Person_evidence | WBPerson220 | ||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | CHROMOSOME_X | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | sel-7 | Person_evidence | WBPerson220 | |||||
Sequence_name | K04G11.2 | ||||||||
Molecular_name (3) | |||||||||
Other_name | CELE_K04G11.2 | Accession_evidence | NDB | BX284606 | |||||
Public_name | sel-7 | ||||||||
DB_info | Database | AceView | gene | XO950 | |||||
WormQTL | gene | WBGene00004764 | |||||||
SignaLink | protein | WBGene00004764 | |||||||
WormFlux | gene | WBGene00004764 | |||||||
NDB | locus_tag | CELE_K04G11.2 | |||||||
NCBI | gene | 181539 | |||||||
RefSeq | protein | NM_077991.7 | |||||||
SwissProt | UniProtAcc | G5EGS7 | |||||||
UniProt_GCRP | UniProtAcc | G5EGS7 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | sel | ||||||||
Allele (173) | |||||||||
Legacy_information | See also n1253 | ||||||||
[C.elegansII] n1253 : suppressor of lin-12 hypermorph (n302sd)[JT; MT] | |||||||||
Complementation_data | [Thomas J] complements sup-20(n821), let-4(mn105) | ||||||||
Strain | WBStrain00022824 | ||||||||
WBStrain00008056 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (13) | |||||||||
Ortholog (30) | |||||||||
Structured_description | Concise_description | sel-7 encodes a novel protein with two predicted PEST sequences that is conserved in the related nematode C. briggsae and several parasitic nematodes, but has no known homologs in other organisms; sel-7 was identified in screens for suppressors of dominant lin-12 mutations that result in vulvaless and egg-laying defective animals; although loss of SEL-7 function via mutation or RNAi results in no obvious defects in a wild-type background, genetic studies suggests that SEL-7 acts downstream of LIN-12/Notch to positively regulate LIN-12 signaling, perhaps by regulating the activity or formation of the LAG-1, LIN-12(intra), SEL-8 nuclear complex; in vitro, SEL-7 self-associates and also interacts with TIR-1 (F13B10.1B), a protein that contains sterile alpha and Toll interleukin receptor motifs, and MDT-29 (K08E3.8), a glutamine-rich protein similar to mediator complex subunits, however the functional significance of these interactions is not yet known; a SEL-7::GFP translational fusion reveals expression in the nuclei of several cell types, including vulval precursor cells and those of the developing gonad. | Paper_evidence | WBPaper00002959 | |||||
WBPaper00006438 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 10 Aug 2004 00:00:00 | ||||||||
Automated_description | Enables identical protein binding activity and sequence-specific DNA binding activity. Involved in several processes, including lateral inhibition; negative regulation of transcription by RNA polymerase II; and positive regulation of Notch signaling pathway. Located in nucleus. Expressed in body wall musculature; pharyngeal muscle cell; and seam cell. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | K04G11.2 | |||||||
Corresponding_CDS_history | K04G11.2:wp111 | ||||||||
Corresponding_transcript | K04G11.2.1 | ||||||||
Other_sequence (27) | |||||||||
Associated_feature (16) | |||||||||
Experimental_info | RNAi_result | WBRNAi00063693 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00063699 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00067729 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00049931 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00063695 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00063694 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00063696 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00016609 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00049927 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00033963 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00067253 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00063692 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00016605 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr2853 | ||||||||
Expr2854 | |||||||||
Expr8992 | |||||||||
Expr1011523 | |||||||||
Expr1032358 | |||||||||
Expr1153632 | |||||||||
Expr2015735 | |||||||||
Expr2033968 | |||||||||
Drives_construct | WBCnstr00010988 | ||||||||
WBCnstr00013660 | |||||||||
WBCnstr00035402 | |||||||||
Construct_product | WBCnstr00000028 | ||||||||
WBCnstr00010988 | |||||||||
WBCnstr00013660 | |||||||||
WBCnstr00035402 | |||||||||
Microarray_results (24) | |||||||||
Expression_cluster (132) | |||||||||
Interaction (28) | |||||||||
Map_info | Map | X | Position | 16.6845 | Error | 0.003109 | |||
Well_ordered | |||||||||
Positive | Positive_clone | K04G11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | 2_point | 6123 | |||||||
6124 | |||||||||
Multi_point | 2292 | ||||||||
4606 | |||||||||
Pos_neg_data | 6840 | ||||||||
6841 | |||||||||
6842 | |||||||||
6843 | |||||||||
6844 | |||||||||
6845 | |||||||||
6846 | |||||||||
Reference (12) | |||||||||
Method | Gene |