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WormBase Tree Display for Gene: WBGene00001401

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Name Class

WBGene00001401SMapS_parentSequenceH12I13
IdentityVersion1
Name (5)
DB_infoDatabaseAceViewgene2G370
WormQTLgeneWBGene00001401
WormFluxgeneWBGene00001401
NDBlocus_tagCELE_H12I13.4
PanthergeneCAEEL|WormBase=WBGene00001401|UniProtKB=Q9N5M6
familyPTHR12537
NCBIgene174016
RefSeqproteinNM_062815.8
SwissProtUniProtAccQ9N5M6
TREEFAMTREEFAM_IDTF318622
UniProt_GCRPUniProtAccQ9N5M6
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:24WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classfbf
Allele (53)
Legacy_information[Gallegos M, Zhang B] fbf-1(RNAi) animals produce excess sperm and no oocytes (Mog phenotype). Encodes fem-3 PME RNA binding protein, 91% identical to FBF-2
StrainWBStrain00022602
WBStrain00022603
WBStrain00022612
WBStrain00022628
WBStrain00022640
WBStrain00022344
WBStrain00022346
WBStrain00022396
WBStrain00022400
RNASeq_FPKM (74)
GO_annotation (27)
Ortholog (33)
ParalogWBGene00004239Caenorhabditis elegansFrom_analysisInparanoid_8
Panther
WormBase-Compara
WBGene00001402Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
Panther
WormBase-Compara
WBGene00022257Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
Panther
WormBase-Compara
WBGene00004241Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
Panther
WormBase-Compara
WBGene00004243Caenorhabditis elegansFrom_analysisInparanoid_8
Panther
WormBase-Compara
WBGene00004242Caenorhabditis elegansFrom_analysisInparanoid_8
Panther
WormBase-Compara
WBGene00004240Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
WBGene00004244Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00004245Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionfbf-1 encodes an RNA-binding protein that is one of 12 C. elegans members of the PUF family (Pumilio and FBF) of translational regulators; FBF-1 is nearly identical to FBF-2 with which it is largely redundant in regulating two aspects of germline development: 1) maintenance of stem cell proliferation, and 2) the hermaphroditic switch between spermatogenesis and oogenesis; FBF-1 also plays a role in regulating adaptation in the AWC chemosensory neuron by binding and enhancing translation of the egl-4 mRNA; in maintaining germline stem cells, the FBF proteins, acting through NOS-3, negatively regulate the activity of gld-1 mRNA, which encodes a translational repressor required for meiotic entry; in regulating the sperm-to-oocyte switch, the FBFs act downstream of GLD-3 to negatively regulate the activity of fem-3 mRNA, which encodes a novel protein required for germline sex determination; consistent with their role in germline development, FBF-1 and FBF-2 are expressed in the germline cytoplasm, becoming enriched in the mitotic region during the L4 larval and adult stages.Paper_evidenceWBPaper00002949
WBPaper00004396
WBPaper00005265
WBPaper00005566
WBPaper00006369
WBPaper00032496
Curator_confirmedWBPerson1843
Date_last_updated17 Feb 2009 00:00:00
Automated_descriptionEnables mRNA 3'-UTR binding activity. Involved in several processes, including germline cell cycle switching, mitotic to meiotic cell cycle; olfactory learning; and regulation of gene expression. Located in germ cell nucleus and perinuclear region of cytoplasm. Expressed in germ line.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSH12I13.4
Corresponding_transcriptH12I13.4.1
Associated_featureWBsf650110
WBsf1012315
WBsf223128
Gene_product_bindsWBsf027922
WBsf034330
Transcription_factorWBTranscriptionFactor000123
WBTranscriptionFactor000103
Experimental_infoRNAi_resultWBRNAi00061203Inferred_automaticallyRNAi_primary
WBRNAi00066607Inferred_automaticallyRNAi_primary
WBRNAi00027386Inferred_automaticallyRNAi_primary
WBRNAi00092447Inferred_automaticallyRNAi_primary
WBRNAi00087353Inferred_automaticallyRNAi_primary
WBRNAi00087348Inferred_automaticallyRNAi_primary
WBRNAi00091432Inferred_automaticallyRNAi_primary
WBRNAi00027294Inferred_automaticallyRNAi_primary
WBRNAi00087350Inferred_automaticallyRNAi_primary
WBRNAi00087344Inferred_automaticallyRNAi_primary
WBRNAi00061200Inferred_automaticallyRNAi_primary
WBRNAi00094039Inferred_automaticallyRNAi_primary
WBRNAi00092450Inferred_automaticallyRNAi_primary
WBRNAi00117256Inferred_automaticallyRNAi_primary
WBRNAi00092444Inferred_automaticallyRNAi_primary
WBRNAi00082713Inferred_automaticallyRNAi_primary
WBRNAi00077135Inferred_automaticallyRNAi_primary
WBRNAi00061202Inferred_automaticallyRNAi_primary
WBRNAi00025169Inferred_automaticallyRNAi_primary
WBRNAi00087343Inferred_automaticallyRNAi_primary
WBRNAi00061209Inferred_automaticallyRNAi_primary
WBRNAi00078207Inferred_automaticallyRNAi_primary
WBRNAi00061205Inferred_automaticallyRNAi_primary
WBRNAi00092448Inferred_automaticallyRNAi_primary
WBRNAi00087347Inferred_automaticallyRNAi_primary
WBRNAi00087354Inferred_automaticallyRNAi_primary
WBRNAi00077138Inferred_automaticallyRNAi_primary
WBRNAi00049385Inferred_automaticallyRNAi_primary
WBRNAi00087357Inferred_automaticallyRNAi_primary
WBRNAi00077136Inferred_automaticallyRNAi_primary
WBRNAi00077433Inferred_automaticallyRNAi_primary
WBRNAi00087342Inferred_automaticallyRNAi_primary
WBRNAi00061201Inferred_automaticallyRNAi_primary
WBRNAi00082421Inferred_automaticallyRNAi_primary
WBRNAi00078206Inferred_automaticallyRNAi_primary
WBRNAi00086638Inferred_automaticallyRNAi_primary
WBRNAi00092445Inferred_automaticallyRNAi_primary
WBRNAi00087345Inferred_automaticallyRNAi_primary
WBRNAi00087349Inferred_automaticallyRNAi_primary
WBRNAi00087355Inferred_automaticallyRNAi_primary
WBRNAi00087346Inferred_automaticallyRNAi_primary
WBRNAi00087352Inferred_automaticallyRNAi_primary
WBRNAi00061208Inferred_automaticallyRNAi_primary
WBRNAi00082442Inferred_automaticallyRNAi_primary
WBRNAi00061206Inferred_automaticallyRNAi_primary
WBRNAi00025795Inferred_automaticallyRNAi_primary
WBRNAi00061207Inferred_automaticallyRNAi_primary
WBRNAi00013710Inferred_automaticallyRNAi_primary
WBRNAi00071150Inferred_automaticallyRNAi_primary
WBRNAi00016250Inferred_automaticallyRNAi_primary
WBRNAi00064692Inferred_automaticallyRNAi_primary
WBRNAi00064571Inferred_automaticallyRNAi_primary
WBRNAi00092449Inferred_automaticallyRNAi_primary
WBRNAi00075630Inferred_automaticallyRNAi_primary
WBRNAi00087356Inferred_automaticallyRNAi_primary
WBRNAi00061204Inferred_automaticallyRNAi_primary
WBRNAi00064611Inferred_automaticallyRNAi_primary
WBRNAi00087351Inferred_automaticallyRNAi_primary
Expr_pattern (14)
Drives_constructWBCnstr00005287
WBCnstr00036969
Construct_productWBCnstr00000086
WBCnstr00005234
WBCnstr00036969
WBCnstr00040358
WBCnstr00042579
Regulate_expr_clusterWBPaper00035905:FBF-1_Associated
WBPaper00045618:fbf-1_downregulated
WBPaper00045618:fbf-1_upregulated
WBPaper00055804:FBF-1-FBF-2-associated_oogenic-enriched
WBPaper00055804:FBF-1-FBF-2-associated_spermatogenic-enriched
AntibodyWBAntibody00000156
WBAntibody00000784
WBAntibody00000964
WBAntibody00001086
WBAntibody00002142
WBAntibody00002385
Microarray_results (20)
Expression_cluster (131)
Interaction (89)
Map_infoMapIIPosition-0.571982Error0.010563
PositivePositive_clone (2)
Mapping_dataMulti_point4304
4305
5274
Pseudo_map_position
Reference (142)
PictureWBPicture0000013095
RemarkData extracted from Zhang et al. (1997)
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene