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WormBase Tree Display for Gene: WBGene00000939

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Name Class

WBGene00000939EvidencePaper_evidenceWBPaper00004772
SMapS_parentSequenceK12H4
IdentityVersion1
NameCGC_namedcr-1Person_evidenceWBPerson419
Sequence_nameK12H4.8
Molecular_nameK12H4.8
K12H4.8.1
CE47418
Other_namelet-740CGC_data_submission
eri-4Paper_evidenceWBPaper00035199
CELE_K12H4.8Accession_evidenceNDBBX284603
Public_namedcr-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:22WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classdcr
Allele (78)
Legacy_informationHomozygous s2624 and s2795 each develope into sterile adults.
Strain (13)
RNASeq_FPKM (74)
GO_annotation (61)
Ortholog (58)
ParalogWBGene00001090Caenorhabditis elegansFrom_analysisTreeFam
WBGene00008400Caenorhabditis elegansFrom_analysisTreeFam
Structured_descriptionConcise_descriptiondcr-1 encodes a bidentate ribonuclease that is homologous to E. coli RNAse III; DCR-1 is required both for RNA interference and for synthesis of small developmental RNAs; DCR-1 functions to process pre-miRNAs into their mature, 22-nt form; DCR-1 interacts in vivo with RDE-4, a double-stranded RNA (dsRNA) binding protein required for RNAi that interacts with trigger dsRNAs and may function to deliver dsRNAs to DCR-1 for endonucleolytic processing; DCR-1 is also required for fragmention of chromosomal DNA during apoptosis, and undergoes a CED-3 protease-mediated conversion from a ribonuclease to a deoxyribonuclease.Paper_evidenceWBPaper00004424
WBPaper00004923
WBPaper00005368
WBPaper00036025
WBPaper00024573
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated03 Feb 2014 00:00:00
Automated_descriptionEnables deoxyribonuclease I activity and ribonuclease III activity. Involved in several processes, including nucleic acid metabolic process; olfactory learning; and positive regulation of primary miRNA processing. Acts upstream of or within defense response to Gram-positive bacterium. Located in cytosol and nucleus. Expressed in germ line; intestine; neurons; and somatic cell. Human ortholog(s) of this gene implicated in several diseases, including DICER1 syndrome; gastrointestinal system cancer (multiple); and multinodular goiter. Is an ortholog of human DICER1 (dicer 1, ribonuclease III).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (8)
Molecular_infoCorresponding_CDSK12H4.8
Corresponding_CDS_historyK12H4.8:wp230
Corresponding_transcriptK12H4.8.1
Other_sequence (58)
Associated_featureWBsf651241
WBsf667129
WBsf227077
WBsf227078
Experimental_infoRNAi_resultWBRNAi00094398Inferred_automaticallyRNAi_primary
WBRNAi00087146Inferred_automaticallyRNAi_primary
WBRNAi00084940Inferred_automaticallyRNAi_primary
WBRNAi00092814Inferred_automaticallyRNAi_primary
WBRNAi00086724Inferred_automaticallyRNAi_primary
WBRNAi00069178Inferred_automaticallyRNAi_primary
WBRNAi00080909Inferred_automaticallyRNAi_primary
WBRNAi00065492Inferred_automaticallyRNAi_primary
WBRNAi00086936Inferred_automaticallyRNAi_primary
WBRNAi00092812Inferred_automaticallyRNAi_primary
WBRNAi00084942Inferred_automaticallyRNAi_primary
WBRNAi00050693Inferred_automaticallyRNAi_primary
WBRNAi00080905Inferred_automaticallyRNAi_primary
WBRNAi00005454Inferred_automaticallyRNAi_primary
WBRNAi00098862Inferred_automaticallyRNAi_primary
WBRNAi00087166Inferred_automaticallyRNAi_primary
WBRNAi00075590Inferred_automaticallyRNAi_primary
WBRNAi00084932Inferred_automaticallyRNAi_primary
WBRNAi00064309Inferred_automaticallyRNAi_primary
WBRNAi00084938Inferred_automaticallyRNAi_primary
WBRNAi00092815Inferred_automaticallyRNAi_primary
WBRNAi00069177Inferred_automaticallyRNAi_primary
WBRNAi00098860Inferred_automaticallyRNAi_primary
WBRNAi00080911Inferred_automaticallyRNAi_primary
WBRNAi00097783Inferred_automaticallyRNAi_primary
WBRNAi00084936Inferred_automaticallyRNAi_primary
WBRNAi00084935Inferred_automaticallyRNAi_primary
WBRNAi00092813Inferred_automaticallyRNAi_primary
WBRNAi00086941Inferred_automaticallyRNAi_primary
WBRNAi00077677Inferred_automaticallyRNAi_primary
WBRNAi00069180Inferred_automaticallyRNAi_primary
WBRNAi00077853Inferred_automaticallyRNAi_primary
WBRNAi00092816Inferred_automaticallyRNAi_primary
WBRNAi00093728Inferred_automaticallyRNAi_primary
WBRNAi00084933Inferred_automaticallyRNAi_primary
WBRNAi00069181Inferred_automaticallyRNAi_primary
WBRNAi00065488Inferred_automaticallyRNAi_primary
WBRNAi00025961Inferred_automaticallyRNAi_primary
WBRNAi00086939Inferred_automaticallyRNAi_primary
WBRNAi00061324Inferred_automaticallyRNAi_primary
WBRNAi00027417Inferred_automaticallyRNAi_primary
WBRNAi00084943Inferred_automaticallyRNAi_primary
WBRNAi00086940Inferred_automaticallyRNAi_primary
WBRNAi00081921Inferred_automaticallyRNAi_primary
WBRNAi00113788Inferred_automaticallyRNAi_primary
WBRNAi00017068Inferred_automaticallyRNAi_primary
WBRNAi00086731Inferred_automaticallyRNAi_primary
WBRNAi00085190Inferred_automaticallyRNAi_primary
WBRNAi00084941Inferred_automaticallyRNAi_primary
WBRNAi00098861Inferred_automaticallyRNAi_primary
WBRNAi00069179Inferred_automaticallyRNAi_primary
WBRNAi00007700Inferred_automaticallyRNAi_primary
WBRNAi00065491Inferred_automaticallyRNAi_primary
WBRNAi00084937Inferred_automaticallyRNAi_primary
WBRNAi00080912Inferred_automaticallyRNAi_primary
WBRNAi00084939Inferred_automaticallyRNAi_primary
WBRNAi00065487Inferred_automaticallyRNAi_primary
WBRNAi00062926Inferred_automaticallyRNAi_primary
WBRNAi00084934Inferred_automaticallyRNAi_primary
WBRNAi00081702Inferred_automaticallyRNAi_primary
WBRNAi00077540Inferred_automaticallyRNAi_primary
WBRNAi00086937Inferred_automaticallyRNAi_primary
WBRNAi00086942Inferred_automaticallyRNAi_primary
WBRNAi00080907Inferred_automaticallyRNAi_primary
WBRNAi00086938Inferred_automaticallyRNAi_primary
Expr_patternExpr10581
Expr11565
Expr12215
Expr12472
Expr1022725
Expr1030586
Expr1154395
Expr2010807
Expr2029044
Drives_constructWBCnstr00005999
WBCnstr00006000
WBCnstr00006001
WBCnstr00017007
WBCnstr00020414
WBCnstr00037186
Construct_product (13)
Regulate_expr_clusterWBPaper00027057:DCR-1_interacting_adult
WBPaper00027057:DCR-1_interacting_embryo
WBPaper00029437:dcr-1_downregulated
WBPaper00029437:dcr-1_upregulated
WBPaper00059490:dcr-1(m9375)_downregulated
WBPaper00059490:dcr-1(m9375)_upregulated
AntibodyWBAntibody00000418
WBAntibody00001054
WBAntibody00001326
WBAntibody00001327
WBAntibody00001490
WBAntibody00002257
WBAntibody00002600
Microarray_results (18)
Expression_cluster (137)
Interaction (219)
WBProcessWBbiopr:00000014
WBbiopr:00000039
WBbiopr:00000057
WBbiopr:00000073
WBbiopr:00000081
Map_infoMapIIIPosition-0.385999Error0.003601
Hide_underWBGene00002843
PositiveInside_rearrnDf20
sDp3
sDp8
Positive_cloneK12H4Inferred_automaticallyFrom sequence, transcript, pseudogene data
NegativeOutside_rearrsDf128
Mapping_dataMulti_point5311
Pos_neg_data9651
9674
9694
9695
9715
Reference (124)
RemarkThe let-740 gene is the same gene as dcr-1 and they therefore have been merged following advice from the CGC. let-740 is now an other name for dcr-1 [krb 030508]
MethodGene