F53B6.7 encodes a member of the histidine phosphatase superfamilyorthologous to Bombyx mori ecdysteroid phosphate phosphatase (EPP),human STS1 (OMIM:609201) and human UBASH3A (OMIM:605736); F53B6.7 lacksthe consensus sequence for phosphatase activity, and thus is predictedto be catalytically inactive; F53B6.7 is paralogous to C. elegansC52E4.7, F09C12.8, F55A11.11, and T07F12.1; loss of F53B6.7 activity vialarge-scale RNAi results in no obvious defects.
Enriched in OLL; PVD; germ line; and in male based on proteomic; microarray; and RNA-seq studies. Is affected by several genes including daf-2; skn-1; and dpy-10 based on microarray and RNA-seq studies. Is affected by seventeen chemicals including Ethanol; methylmercuric chloride; and manganese chloride based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: Histidine phosphatase superfamily; Histidine phosphatase superfamily (branch 1); and Histidine phosphatase superfamily, clade-1.