Enriched in several structures, including AIZ; coelomocyte; germline precursor cell; head mesodermal cell; and sensory neurons based on microarray; tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including daf-16; daf-2; and glp-1 based on microarray; proteomic; and RNA-seq studies. Is affected by twenty-five chemicals including rotenone; 4-bromodiphenyl ether; and levamisole based on RNA-seq and microarray studies. Human ortholog(s) of this gene implicated in male infertility. Human TXNDC2 enables thioredoxin-disulfide reductase (NADP) activity. Is predicted to encode a protein with the following domains: Thioredoxin-like superfamily; Thioredoxin domain; and Thioredoxin. Is an ortholog of human TXNDC2 (thioredoxin domain containing 2) and TXNDC8 (thioredoxin domain containing 8).