WormBase Tree Display for Gene: WBGene00022377

WBGene00022377 SMap: S_parent: Sequence: Y94H6A
  Identity: Version: 2
    Name: CGC_name: gpx-4 Person_evidence: WBPerson261
            WBPerson1141
      Sequence_name: Y94H6A.4
      Molecular_name: Y94H6A.4
        Y94H6A.4.1
        CE34620
      Other_name: Y94H6A.g Curator_confirmed: WBPerson1983
          Remark: Old cosmid naming mapped via unique overlapping PCR_product on CDSs
        CELE_Y94H6A.4 Accession_evidence: NDB BX284604
      Public_name: gpx-4
    DB_info: Database: AceView gene 4D436
        WormQTL gene WBGene00022377
        WormFlux gene WBGene00022377
        NDB locus_tag CELE_Y94H6A.4
        Panther gene CAEEL|WormBase=WBGene00022377|UniProtKB=Q9N2X2
          family PTHR11592
        NCBI gene 190801
        RefSeq protein NM_067841.5
        TrEMBL UniProtAcc Q9N2X2
        UniProt_GCRP UniProtAcc Q9N2X2
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:05 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 20 Jul 2012 14:20:02 WBPerson2970 Name_change: CGC_name: gpx-4
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: gpx
    Allele (52)
    RNASeq_FPKM (74)
    GO_annotation: 00093371
      00093372
      00093373
      00093374
      00093375
      00126495
      00126496
    Ortholog (35)
    Paralog: WBGene00007516 Caenorhabditis elegans From_analysis (2)
      WBGene00007517 Caenorhabditis elegans From_analysis (2)
      WBGene00009165 Caenorhabditis elegans From_analysis (2)
      WBGene00011045 Caenorhabditis elegans From_analysis (2)
      WBGene00018850 Caenorhabditis elegans From_analysis: Panther
      WBGene00019846 Caenorhabditis elegans From_analysis (2)
      WBGene00020373 Caenorhabditis elegans From_analysis (2)
    Structured_description: Automated_description: Predicted to enable glutathione peroxidase activity. Predicted to be involved in cellular oxidant detoxification and response to oxidative stress. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including diabetes mellitus (multiple); gastrointestinal system cancer (multiple); and respiratory system cancer (multiple). Is an ortholog of human GPX3 (glutathione peroxidase 3) and GPX5 (glutathione peroxidase 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:224 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:1184 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:0050860 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:9744 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:3910 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:9538 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:3748 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:9408 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:9352 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:1993 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:3572 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:7941 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:4914 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:10590 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:13129 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:0050731 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:10534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:10591 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:10763 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:6713 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:1324 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:4948 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:1682 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:1287 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:5041 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:418 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:0060901 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:3526 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:0080199 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:0080797 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:9206 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:3021 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:3393 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
      DOID:684 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4555)
  Molecular_info: Corresponding_CDS: Y94H6A.4
    Corresponding_CDS_history: Y94H6A.4:wp102
    Corresponding_transcript: Y94H6A.4.1
    Other_sequence (15)
    Associated_feature: WBsf995750
      WBsf1016931
  Experimental_info: RNAi_result: WBRNAi00058655 Inferred_automatically: RNAi_primary
      WBRNAi00037919 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1021814
      Expr1162077
      Expr2012218
      Expr2030454
    Drives_construct: WBCnstr00019127
    Microarray_results (15)
    Expression_cluster (88)
    Interaction (20)
  Map_info: Map: IV Position: -6.7608
    Positive: Positive_clone: Y94H6A Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00042257
    WBPaper00045706
    WBPaper00045770
    WBPaper00053864
    WBPaper00055090
    WBPaper00058783
    WBPaper00059551
    WBPaper00061220
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene