WormBase Tree Display for Gene: WBGene00004918

WBGene00004918 Evidence: Paper_evidence: WBPaper00005457
  SMap: S_parent: Sequence: ZK652
  Identity (6)
  Gene_info: Biotype: SO:0001217
    Gene_class: snr
    Allele: WBVar01500260
      WBVar01499774
    Strain: WBStrain00051877
    RNASeq_FPKM (74)
    GO_annotation (21)
    Ortholog (36)
    Paralog: WBGene00003080 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: snr-5 encodes an ortholog of human small nuclear ribonucleoprotein SmF, a protein that forms part of a heptameric complex required for biogenesis and function of the snRNPs that catalyze mRNA splicing; in combination with the gene that encodes the human SmE and SmG orthologs (snr-6 and snr-7, respectively), snr-5 affects embryonic viability and nuclear association and localization of P granules in embryos, based on an RNAi assay; affects embryonic and larval viability based on large-scale RNAi assays; snr-5 is expressed in embryos and adult gonads. Paper_evidence: WBPaper00005654
          Curator_confirmed: WBPerson48
          Date_last_updated: 11 Jul 2005 00:00:00
      Automated_description: Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in cytosol and nucleus. Predicted to be part of U1 snRNP; catalytic step 2 spliceosome; and pICln-Sm protein complex. Expressed in several structures, including enteric muscle; excretory cell; hypodermis; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in nasopharynx carcinoma. Is an ortholog of human SNRPF (small nuclear ribonucleoprotein polypeptide F). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9261 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11162)
  Molecular_info: Corresponding_CDS: ZK652.1
    Corresponding_transcript: ZK652.1.1
    Other_sequence: ES411615.1
      JI176293.1
      TDC00368_1
      NBC00260_1
      LSC00615_1
      Dviv_isotig12294
      Tcol_isotig04419
      BU086611.1
      Tcol_isotig04417
      DN557803.1
      GW411362.1
      TMC00882_1
      CB043804.1
      PSC01286_2
      BXC06040_1
      CBC06336_1
      Tcol_isotig04421
      HCC00723_1
      DIC01555_1
      AE01278
      EX911516.1
      CB037617.1
      HG01504
      GW410091.1
      DI00389
      HC03775
      MIC05554_1
      Tcir_isotig12860
      GW412832.1
      SSC06530_1
      ES739715.1
      MI06695
      Acan_isotig01638
      FC813825.1
      Tcol_isotig04416
      XI00307
      HG01583
      HC01252
      BMC02602_1
      SR04654
      RSC00723_1
      NAC01359_1
      Dviv_isotig12295
      AYC00536_1
      SS02565
      Dviv_isotig12296
      AE01433
      CB043042.1
      Tcir_isotig17656
      HBC12815_1
      XIC00695_1
      SRC06131_1
      PPC00575_1
      ACC04015_1
      Dviv_isotig12293
      Tcol_isotig21768
      Tcol_isotig04418
      DN557420.1
      RS07885
      Tcol_isotig04420
      GRC02350_1
      GR13211
      HGC00502_1
      GW410887.1
      HC00421
      CB036995.1
      OOC03270_1
      CJC00979_1
      HCC12373_1
      TM01282
      TDC00019_1
      ES740320.1
      PP01585
      NB07924
    Associated_feature: WBsf654935
      WBsf225289
  Experimental_info: RNAi_result (23)
    Expr_pattern: Chronogram734
      Expr2229
      Expr7238
      Expr1012073
      Expr1032447
      Expr1163018
      Expr2015969
      Expr2034204
    Drives_construct: WBCnstr00004145
      WBCnstr00035322
    Construct_product: WBCnstr00035322
    Antibody: WBAntibody00000550
      WBAntibody00000552
      WBAntibody00000553
      WBAntibody00000554
    Microarray_results (23)
    Expression_cluster (126)
    Interaction (202)
  Map_info: Map: III Position: -0.534667 Error: 0.000692
    Positive: Positive_clone: ZK652 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00005457
    WBPaper00038491
    WBPaper00040897
    WBPaper00046427
    WBPaper00046572
    WBPaper00055090
  Remark: Locus was previously incorrectly associated with Y71G12B.14 [krb 030219]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene