Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00000802

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00000802SMapS_parentSequenceY38A10A
IdentityVersion1
NameCGC_namecrt-1
Sequence_nameY38A10A.5
Molecular_nameY38A10A.5
Y38A10A.5.1
CE21562
Other_nameCELE_Y38A10A.5Accession_evidenceNDBBX284605
Public_namecrt-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:21WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classcrt
Allele (34)
Legacy_information[C.elegansII] NMK. Encodes predicted 395 aa calreticulin(61% identity to mouse calreticulin). [Smith 1992]
StrainWBStrain00023525
WBStrain00031729
WBStrain00040781
WBStrain00040782
WBStrain00040783
WBStrain00040784
RNASeq_FPKM (74)
GO_annotation (31)
Ortholog (47)
ParalogWBGene00000567Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptioncrt-1 encodes an ortholog of calreticulin (a calcium-binding molecularchaperone of the endoplasmic reticulum); crt-1 is dispensable forviability, but required for normal sperm development, male matingefficiency, some forms of necrotic cell death, and hermaphrodite fertilityat high temperatures (which may reflect a stress response); crt-1expression is induced by stress; CRT-1 protein binds Ca(2+) and cansuppress heat-induced protein aggregation in vitro; crt-1(bz29) andcrt-1(bz30) mutants suppress necrotic cell death induced either bymec-4(d) or by a constitutively activated Gas subunit; crt-1(bz29);crt-1's suppression of necrosis is itself partly reversed by thapsigargin,which enhances calcium release from the endoplasmic reticulum;crt-1(bz30), and crt-1(jh101) mutants grow more slowly, and have havereduced broods at 25 deg. C.; crt-1(jh101) mutants are slightly shorterthan normal and have defective sperm; CRT-1 and ITR-1 serve partlyredundant functions in vivo, since crt-1;itr-1(sa73) are highly infertileand slow-growing with greatly slowed defecation; a number of proteins,notably HSP-3/4 and PDI-2/3, are over-expressed in crt-1(jh101) mutantsand crt-1(jh101);cnx-1(nr2009) double mutants.Paper_evidenceWBPaper00004858
WBPaper00004880
WBPaper00027024
Curator_confirmedWBPerson567
Date_last_updated21 Aug 2006 00:00:00
Automated_descriptionEnables calcium ion binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; determination of adult lifespan; and hemidesmosome assembly. Located in cytoplasm. Expressed in several structures, including coelomocyte; excretory system; intestine; pharynx; and sperm. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in several diseases, including endocrine gland cancer (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Is an ortholog of human CALR (calreticulin).Paper_evidenceWBPaper00065943
Curator_confirmed (2)
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:14330Homo sapiensPaper_evidenceWBPaper00053621
Curator_confirmedWBPerson324
Date_last_updated04 Mar 2019 00:00:00
Potential_model (22)
Models_disease_assertedWBDOannot00000639
Molecular_infoCorresponding_CDSY38A10A.5
Corresponding_transcriptY38A10A.5.1
Other_sequenceNB12095
ES743663.1
GW410848.1
PVC01982_1
HBC00231_1
GO239236.1
EX009103.1
HSC00996_1
EW742320.1
EX913088.1
CBC00113_1
Tcol_isotig04079
FG974735.1
PPC00388_1
FK808623.1
FC811593.1
SRC07317_1
FG979597.1
FG976846.1
GQ396798.1
EX549298.1
BF599213.1
FK800143.1
BXC01393_1
EX010351.1
HG07620
EX914867.1
EX914017.1
HC02895
AW288154.1
HS00702
FF680619.1
FK804151.1
CJC08093_1
PTC00804_1
TS00444
FC816827.1
FK809547.1
HG04770
BXC04544_1
FF680034.1
FK804448.1
JI176432.1
HC01319
FC818469.1
AI601087.1
CRC09986_1
SRC09014_1
OVC01148_1
Dviv_isotig28546
EU360890.1
EX547360.1
CR10158
FG974663.1
FK801322.1
AF052978.1
CR06782
FC811926.1
GR978289.1
BG577619.1
HS01102
HC03456
SRC08177_1
ES570222.1
ACC00406_1
FC817523.1
GW406852.1
HC00341
FC819861.1
NB10625
EX911881.1
HBC03265_1
SRC08389_1
FC814815.1
FG975235.1
GW406986.1
FK800686.1
BMC12472_1
HC03140
FK801733.1
AJ006790.1
FC814983.1
DI00926
EX547612.1
FG980835.1
SRC07132_1
BMC03611_1
JI476030.1
FC818801.1
EX541018.1
SSC00126_1
HGC10664_1
CSC01006_1
ACC06019_1
EX912330.1
EX534766.1
SRC08312_1
SRC09010_1
FF679260.1
FC541675.1
EX538674.1
JI467314.1
FE917627.1
AE03945
FD514481.1
FC814946.1
CBC09215_1
MIC05398_1
BM277319.1
EX915989.1
FG975079.1
CBC00837_1
EX013424.1
TMC00495_1
GW413452.1
HGC10407_1
BF199430.1
Tcol_isotig04080
AI665769.1
JI467003.1
HG03578
JO470221.1
BMC05824_1
FC815558.1
JI169385.1
TSC01562_1
TSC08361_1
FC817154.1
EX007454.1
SS01569
DA06094
EX912716.1
EX009944.1
AI692154.1
AW288222.1
SRC08876_1
ES408955.1
EX535407.1
ES566192.1
FG977401.1
Tcir_isotig16138
AW288141.1
BM174321.1
BMC13759_1
CD455808.1
BE239196.1
MIC02964_1
AI374093.1
FG976762.1
EX010231.1
SRC08917_1
FF678582.1
EX013901.1
GU013560.1
FC819542.1
FC813921.1
ES411154.1
CR12508
HG05027
Acan_isotig08324
HG08804
RS06031
DIC00306_1
CR02845
SRC10353_1
FF679862.1
ES562269.1
RS09752
PT00127
ES409800.1
FD515482.1
XIC05692_1
FK808957.1
CR07587
XI00925
AE02089
HG09330
DAC00389_1
HC01819
Name_isotig01181
EX502563.1
GQ150476.1
AS00961
JI169766.1
BU087110.1
FF679885.1
CR10157
AE00766
SC00167
HCC00592_1
ES410697.1
XIC00780_1
HBC17290_1
AI111223.1
TMC01489_1
FC811319.1
BM174370.1
BG467567.1
CRC00528_1
GT571135.1
PP00609
HG02597
FC553145.1
ES739710.1
FC550572.1
ES409078.1
FG978910.1
JI172767.1
HSC00338_1
CJC00580_3
AA668089.1
RS07319
FC545220.1
EW741997.1
BF400366.1
HGC01952_1
EX542237.1
BMC12461_1
AI368270.1
FK802530.1
FG580656.1
EV851270.1
ES741528.1
ES411668.1
JO473368.1
FF678369.1
AM296015.1
MHC03324_1
NBC00808_1
CR11420
ASC16533_1
Oden_isotig17754
ES413809.1
JI245261.1
GU585910.1
FG971623.1
NB08442
NAC00261_1
BMC04366_1
JI461351.1
CJC01164_1
PPC00042_1
MH08133
FG975137.1
ES740916.1
EX564470.1
AF402771.1
SR01041
FF679531.1
AYC04225_1
M20565.1
SRC10455_1
PSC02604
BUC00817_1
HG00221
EX007723.1
FG971182.1
SRC09491_1
FG977817.1
SRC08458_1
FK806655.1
MI02454
AYC02576_1
GR978885.1
OVC03948_1
RSC04344_1
FE919714.1
SRC00185_1
GR977876.1
EL889874.1
ES410159.1
BMC06194_1
GR978038.1
JI173600.1
EX014870.1
AI603821.1
FF678664.1
TM01780
FC809636.1
EX551539.1
CJC00580_1
Tcol_isotig04078
SRC08771_1
EX549852.1
FK809402.1
FK803046.1
FF681496.1
FE917607.1
FK808345.1
FG978119.1
ES739911.1
FE913559.1
OVC08131_1
FF679199.1
Hbac_isotig01528
FC813083.1
SRC08360_1
EX010015.1
ACC22445_1
CD455381.1
HQ843774.1
FC809666.1
XI05009
XIC01238_1
SRC09241_1
FG972068.1
Associated_feature (15)
Experimental_infoRNAi_result (25)
Expr_pattern (12)
Drives_constructWBCnstr00000682
WBCnstr00010817
WBCnstr00037266
Construct_productWBCnstr00006884
WBCnstr00037266
Regulate_expr_clusterWBPaper00064957:crt-1(jvp1)_downregulated
WBPaper00064957:crt-1(jvp1)_upregulated
WBPaper00064957:crt-1(knu358)_downregulated
WBPaper00064957:crt-1(knu358)_upregulated
AntibodyWBAntibody00000408
Microarray_results (24)
Expression_cluster (193)
Interaction (116)
WBProcessWBbiopr:00000046
WBbiopr:00000079
Map_infoMapVPosition-0.354153Error0.004638
PositivePositive_cloneY38A10AInferred_automaticallyFrom sequence, transcript, pseudogene data
ZL188
Mapping_dataMulti_point4240
4964
5324
Pseudo_map_position
Reference (72)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene