WormBase Tree Display for Gene: WBGene00022856

WBGene00022856 SMap: S_parent: Sequence: ZK1127
  Identity: Version: 2
    Name: CGC_name: cth-2 Person_evidence: WBPerson1711
      Sequence_name: ZK1127.10
      Molecular_name (3)
      Other_name: CELE_ZK1127.10 Accession_evidence: NDB BX284602
      Public_name: cth-2
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:06 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 10 Sep 2008 16:37:04 WBPerson2970 Name_change: CGC_name: cth-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cth
    Allele (15)
    Strain: WBStrain00007972
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog: WBGene00042787 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00152250 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00054249 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00109584 Pristionchus pacificus From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00194401 Caenorhabditis brenneri From_analysis: TreeFam
            WormBase-Compara
      WBGene00075890 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00054295 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00121794 Caenorhabditis japonica From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00227890 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g7404 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g3578 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g4413 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g1263 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g17413 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g2108 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g10009 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g21350 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g7613 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g8410 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00619.g12862 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cnig_chr_II.g5256 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g12170 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00302.g9028 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_16972 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_006411 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g02192 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g18740 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g8649 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_20264210 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrII_pilon.g4923 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00247861 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00273954 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00256758 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00299309 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000000010 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0000566 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-030131-774 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-040905-3 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:2501 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1339968 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:2443 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog: WBGene00007533 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009048 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
    Structured_description: Concise_description: cth-2 encodes a putative cystathionine gamma-lyase; CTH-2 is orthologous to human CTH (OMIM:607657, mutated in cystathioninuria), extremely similar to its paralog CTH-1, and also paralogous to CBL-1; either CTH-2, or CTH-1, or both proteins weakly inhibitDHC-1 in vivo; CTH-2 is expressed in both larval and adult hypodermis, anal depressor muscle, and body wall muscle, as well as in adult vulval muscle and reproductive system; CTH-2 binds SMN-1 in yeast two-hybrid assays. Paper_evidence: WBPaper00006525
            WBPaper00028478
            WBPaper00030897
          Curator_confirmed: WBPerson1843
            WBPerson1823
            WBPerson567
          Date_last_updated: 15 Sep 2011 00:00:00
      Automated_description: Predicted to enable cystathionine gamma-lyase activity and pyridoxal phosphate binding activity. Predicted to be involved in cysteine biosynthetic process via cystathionine and transsulfuration. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in cystathioninuria. Is an ortholog of human CTH (cystathionine gamma-lyase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9252 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2501)
      DOID:0090142 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2501)
  Molecular_info: Corresponding_CDS: ZK1127.10
    Corresponding_transcript: ZK1127.10.1
    Other_sequence (100)
    Associated_feature: WBsf650204
      WBsf655366
      WBsf655367
      WBsf665670
      WBsf988344
      WBsf1012482
      WBsf223280
      WBsf223281
  Experimental_info: RNAi_result (15)
    Expr_pattern: Chronogram527
      Expr7188
      Expr9561
      Expr1017288
      Expr1040112
      Expr1162551
      Expr2010574
      Expr2028814
    Drives_construct: WBCnstr00002589
      WBCnstr00023917
      WBCnstr00040868
    Construct_product: WBCnstr00014126
      WBCnstr00023917
      WBCnstr00040868
      WBCnstr00040869
      WBCnstr00040870
      WBCnstr00040871
      WBCnstr00040872
    Microarray_results (20)
    Expression_cluster (250)
    Interaction (91)
  Map_info: Map: II Position: 0.361481 Error: 0.004775
    Positive: Positive_clone: ZK1127 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (12)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene