WormBase Tree Display for Gene: WBGene00019565

WBGene00019565 SMap: S_parent: Sequence: K09D9
  Identity: Version: 2
    Name: CGC_name: cyp-35A3
      Sequence_name: K09D9.2
      Molecular_name: K09D9.2
        K09D9.2.1
        CE21056
      Other_name: CELE_K09D9.2 Accession_evidence: NDB BX284605
      Public_name: cyp-35A3
    DB_info: Database: AceView gene 5E497
        WormQTL gene WBGene00019565
        WormFlux gene WBGene00019565
        NDB locus_tag CELE_K09D9.2
        Panther gene CAEEL|WormBase=WBGene00019565|UniProtKB=Q9N5I1
          family PTHR24300
        NCBI gene 187209
        RefSeq protein NM_071720.6
        TrEMBL UniProtAcc Q9N5I1
        UniProt_GCRP UniProtAcc Q9N5I1
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:01 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 21 Sep 2004 09:38:16 WBPerson1971 Name_change: CGC_name: cyp-35A3
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cyp
    Allele (50)
    Strain: WBStrain00032730
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog: WBGene00056778 Caenorhabditis remanei From_analysis: TreeFam
            WormBase-Compara
      WBGene00024635 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
      WBGene00024637 Caenorhabditis briggsae From_analysis: OrthoMCL
      WBGene00024643 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
      WBGene00141681 Caenorhabditis brenneri From_analysis: TreeFam
            WormBase-Compara
      WBGene00194333 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00024634 Caenorhabditis briggsae From_analysis: WormBase-Compara
      CBOVI.g1868 Caenorhabditis bovis From_analysis: WormBase-Compara
      CBOVI.g1869 Caenorhabditis bovis From_analysis: WormBase-Compara
      CBOVI.g1870 Caenorhabditis bovis From_analysis: WormBase-Compara
      CBOVI.g2007 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP26.g11067 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP26.g11284 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP26.g11285 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g16634 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP28.g16635 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP28.g3291 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g19018 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP29.g21605 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP32.g1054 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP32.g11570 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g6679 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g10099 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g12669 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g21393 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g6386 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cnig_chr_V.g17623 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Cnig_chr_V.g17638 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g12865 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_04124.g32144 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_02649 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_020122 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g02193 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g06175 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g06484 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g07708 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g10185 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g10548 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g10550 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g12519 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g14462 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g21319 Panagrellus redivivus From_analysis: WormBase-Compara
      chrV_pilon.g13896 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00288234 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0010383 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      ZFIN:ZDB-GENE-020812-2 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-060818-12 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-030131-4664 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-050522-490 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-031030-8 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-040426-790 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-040426-822 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-040426-1571 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-040426-1584 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-040120-2 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-040120-1 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-110114-2 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-040625-72 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-040704-28 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-041010-37 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-041010-183 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-041001-158 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-040912-139 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-050320-144 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-110114-3 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-071004-47 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-080721-19 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-091211-1 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-041001-156 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-070424-33 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-090312-107 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-070424-41 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-061027-109 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-061027-232 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-080724-3 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-041210-324 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-041001-157 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-061030-1 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      ZFIN:ZDB-GENE-041001-155 Danio rerio From_analysis: EnsEMBL-Compara
            OMA
            Panther
      HGNC:2615 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
            Panther
            PhylomeDB
      HGNC:2624 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
            Panther
            PhylomeDB
      HGNC:2625 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
            Panther
            PhylomeDB
      HGNC:2631 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
            Panther
            PhylomeDB
      HGNC:2634 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
            Panther
            PhylomeDB
      HGNC:15654 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
            Panther
            PhylomeDB
      HGNC:20243 Homo sapiens From_analysis: EnsEMBL-Compara
            OMA
            Panther
            PhylomeDB
      MGI:105055 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:88596 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:88597 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:88598 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:88599 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:107303 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:88600 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:103238 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1306806 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1306819 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1306818 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1306815 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:88602 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:88606 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:88607 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:88608 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:109612 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1270149 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1270148 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1929474 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1917138 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1918769 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            PhylomeDB
      MGI:1919332 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1919553 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1921384 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1921769 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1923529 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:2140224 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:2147497 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:2385022 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:3644957 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:2385878 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:1888897 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:2385197 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:3648316 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:3717097 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:3646735 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:88604 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:2686296 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:3642960 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:3612287 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:88603 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:3612288 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:3616076 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:2449816 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:2449817 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      MGI:3721049 Mus musculus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2465 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2466 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2472 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2463 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2464 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2470 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2471 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2475 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2477 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2469 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:620088 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:620379 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2476 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:620007 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:620370 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:620086 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:620368 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:620363 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:620640 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:708427 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:628627 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:628630 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:1305193 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:735174 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:619934 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:1306078 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:1309433 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            PhylomeDB
      RGD:1563215 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:631442 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2467 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:1563697 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:1561242 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:1586963 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:1596474 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2320073 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:2319920 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:9404051 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:9160854 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
      RGD:1564244 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OMA
            Panther
    Paralog (44)
    Structured_description: Concise_description: cyp-35A3 encodes one of over 80 C. elegans cytochrome P450s, NADPH-dependent monooxygenases that metabolize endogenous and exogenous compounds; loss of cyp-35A/C gene family activity in the presence of xenobiotics can diminish the reproductive decline seen in wild-type worms treated with the same compounds; in addition, cyp-35A(RNAi) also results in a reduction of fat content; cyp-35A3 reporter gene fusions are strongly expressed in the intestine following treatment with xenobiotics. Paper_evidence: WBPaper00005655
            WBPaper00025207
            WBPaper00029387
          Curator_confirmed: WBPerson1843
          Date_last_updated: 26 Feb 2009 00:00:00
      Automated_description: Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Involved in response to xenobiotic stimulus. Predicted to be located in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple). Is an ortholog of several human genes including CYP2B6 (cytochrome P450 family 2 subfamily B member 6); CYP2D6 (cytochrome P450 family 2 subfamily D member 6); and CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (42)
  Molecular_info (4)
  Experimental_info: RNAi_result (15)
    Expr_pattern: Expr4664
      Expr1038451
      Expr1154117
      Expr2010736
      Expr2028973
    Drives_construct: WBCnstr00012158
      WBCnstr00025764
    Construct_product: WBCnstr00025764
    Microarray_results (15)
    Expression_cluster (296)
    Interaction (28)
  Map_info: Map: V Position: -7.01998 Error: 0.006429
    Positive: Positive_clone: K09D9 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (16)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene