WormBase Tree Display for Gene: WBGene00018857

WBGene00018857 SMap: S_parent: Sequence: F55A4
  Identity: Version: 2
    Name: CGC_name: stau-1 Person_evidence: WBPerson1574
      Sequence_name: F55A4.5
      Molecular_name: F55A4.5
        F55A4.5.1
        CE11107
      Other_name: CELE_F55A4.5 Accession_evidence: NDB BX284606
      Public_name: stau-1
    DB_info: Database: AceView gene XB646
        WormQTL gene WBGene00018857
        WormFlux gene WBGene00018857
        NDB locus_tag CELE_F55A4.5
        Panther gene CAEEL|WormBase=WBGene00018857|UniProtKB=Q94239
          family PTHR46054
        NCBI gene 180455
        RefSeq protein NM_075795.5
        TREEFAM TREEFAM_ID TF350296
        TrEMBL UniProtAcc Q94239
        UniProt_GCRP UniProtAcc Q94239
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:00 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 28 Jul 2008 09:58:13 WBPerson2970 Name_change: CGC_name: stau-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: stau
    Allele (115)
    Strain: WBStrain00003524
    RNASeq_FPKM (74)
    GO_annotation (19)
    Ortholog: WBGene00060185 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00029936 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00140665 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00120122 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
      WBGene00224653 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g2385 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP26.g821 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g13382 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g542 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g6142 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP38.g3480 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g8198 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g11214 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00252.g7913 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_00252.g7919 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_00252.g7920 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-stau-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold548.g3560 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp11.Scaffold548.g3561 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01262.g19666 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_03163 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_022249 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g01387 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g6235 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_X0012300 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrX_pilon.g18370 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00217289 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00239761 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00089674 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00256071 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00285703 Trichuris muris From_analysis: WormBase-Compara
      WBGene00286814 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0003520 Drosophila melanogaster From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-030131-6372 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-040426-687 Danio rerio From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      HGNC:11370 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:11371 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1338864 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      MGI:1352508 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:621778 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      RGD:621479 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
    Paralog: WBGene00000079 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000080 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00008397 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00011253 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00022388 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: stau-1 encodes a double-stranded RNA (dsRNA)-binding protein orthologous to Drosophila Staufen and mammalian STAU1 and STAU2; STAU-1 binds dsRNA in vitro, showing preference for highly structured RNAs; genetic analyses suggest that stau-1 activity is required for regulation of gene expression, RNA interference, and, along with eri-1, germ cell development; STAU-1 is expressed at all developmental stages, with highest levels seen in embryos. Paper_evidence: WBPaper00041771
          Curator_confirmed: WBPerson1843
          Date_last_updated: 04 Jan 2013 00:00:00
      Automated_description: Enables double-stranded RNA binding activity. Involved in germ cell development and negative regulation of post-transcriptional gene silencing by regulatory ncRNA. Predicted to be located in several cellular components, including cytoplasmic stress granule; neuron projection; and neuronal cell body. Predicted to be part of messenger ribonucleoprotein complex. Human ortholog(s) of this gene implicated in atherosclerosis. Is an ortholog of human STAU1 (staufen double-stranded RNA binding protein 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:1936 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11370)
  Molecular_info: Corresponding_CDS: F55A4.5
    Corresponding_transcript: F55A4.5.1
    Other_sequence: Dviv_isotig16239
      Tcol_isotig22348
      Dviv_isotig16238
      BMC05552_1
      JI165268.1
      Dviv_isotig15347
    Associated_feature (13)
  Experimental_info: RNAi_result: WBRNAi00080631 Inferred_automatically: RNAi_primary
      WBRNAi00015685 Inferred_automatically: RNAi_primary
      WBRNAi00048438 Inferred_automatically: RNAi_primary
      WBRNAi00032846 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1066
      Expr6195
      Expr10656
      Expr1020852
      Expr1038137
      Expr1152225
      Expr2016954
      Expr2035102
    Drives_construct: WBCnstr00003982
      WBCnstr00026237
    Construct_product: WBCnstr00026237
    Regulate_expr_cluster: WBPaper00049286:stau-1(tm2266)_downregulated
      WBPaper00049286:stau-1(tm2266)_upregulated
    Antibody: WBAntibody00002397
    Microarray_results (19)
    Expression_cluster (100)
    Interaction (98)
  Map_info: Map: X Position: -18.8218 Error: 0.010026
    Positive: Positive_clone: F55A4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00024200
    WBPaper00029257
    WBPaper00038491
    WBPaper00040253
    WBPaper00041771
    WBPaper00046432
    WBPaper00047433
    WBPaper00049286
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene