WormBase Tree Display for Gene: WBGene00009920

WBGene00009920 SMap: S_parent: Sequence: F52B5
  Identity: Version: 2
    Name: CGC_name: abts-1 Person_evidence: WBPerson2233
      Sequence_name: F52B5.1
      Molecular_name: F52B5.1a
        F52B5.1a.1
        CE27167
        F52B5.1b
        CE42722
        F52B5.1c
        CE47042
        F52B5.1b.1
        F52B5.1c.1
      Other_name: CELE_F52B5.1 Accession_evidence: NDB BX284601
      Public_name: abts-1
    DB_info: Database: AceView gene 1I874
        WormQTL gene WBGene00009920
        WormFlux gene WBGene00009920
        NDB locus_tag CELE_F52B5.1
        Panther gene CAEEL|WormBase=WBGene00009920|UniProtKB=B3WFV9
          family PTHR11453
        NCBI gene 172613
        RefSeq protein NM_001380825.2
            NM_001380826.1
            NM_001136304.5
        TrEMBL UniProtAcc G5EDF4
            G5EC65
            B3WFV9
        UniProt_GCRP UniProtAcc B3WFV9
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:50 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 19 Jan 2005 16:30:54 WBPerson2970 Name_change: CGC_name: abts-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: abts
    Allele (112)
    Strain: WBStrain00002307
      WBStrain00006136
      WBStrain00032079
    RNASeq_FPKM (74)
    GO_annotation (31)
    Ortholog: WBGene00066611 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00026827 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00155558 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00134573 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00150457 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00194410 Caenorhabditis brenneri From_analysis: TreeFam
            WormBase-Compara
      WBGene00160874 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00152493 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00155525 Caenorhabditis brenneri From_analysis: TreeFam
      WBGene00124619 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00121262 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00051441 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00058260 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00054013 Caenorhabditis remanei From_analysis: TreeFam
      WBGene00125279 Caenorhabditis japonica From_analysis: TreeFam
      WBGene00106401 Pristionchus pacificus From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00096993 Pristionchus pacificus From_analysis: OMA
            WormBase-Compara
      WBGene00224503 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g10044 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g10411 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g1988 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g3705 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g11200 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g9779 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g15552 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g22207 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g29340 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g6973 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g19865 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_18510.g25980 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-abts-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g17027 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00028.g1605 Caenorhabditis sinica From_analysis: WormBase-Compara
      Csp5_scaffold_00028.g1606 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_14316 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_000982 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g05913 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g19083 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_10134620 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrI_pilon.g1556 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00207532 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00209214 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00237808 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00263234 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00292560 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000005219 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoInspector
      FB:FBgn0259111 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-131119-88 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-081105-62 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-060531-64 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-091030-1 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-060526-274 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-140106-104 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-100215-3 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:11030 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      HGNC:11033 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:11034 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:13811 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:18168 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      HGNC:11035 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      MGI:1927555 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      MGI:1928745 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:2150150 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:2443878 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            Panther
            PhylomeDB
            SonicParanoid
      MGI:2443220 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      MGI:2443384 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      RGD:68936 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
            SonicParanoid
      RGD:621208 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:628811 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            PhylomeDB
      RGD:631407 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1303009 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            PhylomeDB
      RGD:735164 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog: WBGene00019844 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00009929 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00019018 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: abts-1 encodes a sodium-driven chloride-bicarbonate transporter; when expressed in Xenopus oocytes, ABTS-1 exhibits robust chloride transport, as well as chloride/bicarbonate exchange activity; abts-1 responds to arsenite in the environment with an increase in mRNA levels and is required for protection against toxicity of arsenite; abts-1 is involved in cholinergic signaling as abts-1 mutant worms are hypersensitive to the paralytic effects of the cholinesterase inhibitor, aldicarb, and the nicotinic acetylcholine receptor agonist, levamisole, and arsenite enhances both these sensitivities, indicating the neuronal effects of arsenite and abts-1; abts-1 also functions partially redundantly with the potassium chloride co-transporter kcc-2, to mediate inhibitory GABA signaling in the HSNs (hermaphrodite-specific neurons) that control egg-laying, and in body wall muscles that control body length and movement; abts-1 promoter gfp fusions are expressed primarily in neurons and hypodermis, with weak fluorescence also seen in the pharynx and body wall muscle cells. Paper_evidence: WBPaper00025075
            WBPaper00036228
            WBPaper00038249
          Curator_confirmed: WBPerson1843
            WBPerson324
          Date_last_updated: 02 May 2011 00:00:00
      Automated_description: Enables chloride transmembrane transporter activity and solute:inorganic anion antiporter activity. Involved in several processes, including cholinergic synaptic transmission; regulation of GABAergic synaptic transmission; and response to serotonin. Predicted to be located in plasma membrane. Expressed in HSN; accessory cell; body wall musculature; head; and pharynx. Human ortholog(s) of this gene implicated in cholangiocarcinoma and renal tubular acidosis. Is an ortholog of human SLC4A10 (solute carrier family 4 member 10); SLC4A7 (solute carrier family 4 member 7); and SLC4A8 (solute carrier family 4 member 8). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:4947 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11030)
      DOID:14219 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11030)
  Molecular_info: Corresponding_CDS: F52B5.1a
      F52B5.1b
      F52B5.1c
    Corresponding_CDS_history: F52B5.1:wp47
      F52B5.1c:wp229
    Corresponding_transcript: F52B5.1a.1
      F52B5.1b.1
      F52B5.1c.1
    Other_sequence (57)
    Associated_feature (22)
  Experimental_info: RNAi_result: WBRNAi00003734 Inferred_automatically: RNAi_primary
      WBRNAi00063711 Inferred_automatically: RNAi_primary
      WBRNAi00082242 Inferred_automatically: RNAi_primary
      WBRNAi00116959 Inferred_automatically: RNAi_primary
      WBRNAi00063709 Inferred_automatically: RNAi_primary
      WBRNAi00082244 Inferred_automatically: RNAi_primary
      WBRNAi00047920 Inferred_automatically: RNAi_primary
      WBRNAi00082243 Inferred_automatically: RNAi_primary
    Expr_pattern (12)
    Drives_construct: WBCnstr00001922
      WBCnstr00004241
      WBCnstr00009643
      WBCnstr00009644
      WBCnstr00011245
      WBCnstr00011899
      WBCnstr00013791
      WBCnstr00013792
      WBCnstr00031815
    Construct_product (4)
    Microarray_results (22)
    Expression_cluster (152)
    Interaction (25)
  Map_info: Map: I Position: 2.71185 Error: 0.006359
    Positive: Positive_clone: F52B5 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5145
        4212
    Pseudo_map_position
  Reference (17)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene