Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00002147

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00002147SMapS_parentSequenceC41C4
IdentityVersion1
NameCGC_nameire-1Person_evidenceWBPerson159
Sequence_nameC41C4.4
Molecular_nameC41C4.4a
C41C4.4a.1
CE35836
C41C4.4b
CE45635
C41C4.4b.1
Other_nameCELE_C41C4.4Accession_evidenceNDBBX284602
Public_nameire-1
DB_infoDatabase (14)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:26WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classire
Allele (160)
StrainWBStrain00031637
WBStrain00033316
WBStrain00034062
RNASeq_FPKM (74)
GO_annotation (56)
OrthologWBGene00034112Caenorhabditis briggsaeFrom_analysisHillier-set
OrthoMCL
OMA
WormBase-Compara
WBGene00145500Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00193219Caenorhabditis brenneriFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00126544Caenorhabditis japonicaFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00053791Caenorhabditis remaneiFrom_analysisOMA
WormBase-Compara
WBGene00222949Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g6821Caenorhabditis bovisFrom_analysisWormBase-Compara
CBOVI.g6824Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g16117Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP21.g16120Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g6514Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g12833Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g6444Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g9395Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP31.g9397Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP38.g13213Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP38.g13215Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g6616Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g19244Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_00115.g4755Caenorhabditis angariaFrom_analysisWormBase-Compara
Cang_2012_03_13_00115.g4757Caenorhabditis angariaFrom_analysisWormBase-Compara
Cni-ire-1Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold630.g18493Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_02566.g27040Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_08786Caenorhabditis latensFrom_analysisWormBase-Compara
FL83_08788Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_005098Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g09362Oscheius tipulaeFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g09364Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g9383Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_20152720Caenorhabditis inopinataFrom_analysisWormBase-Compara
Sp34_20152900Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrII_pilon.g5162Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00247050Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00091492Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00117190Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00273905Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00274756Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00274758Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00259905Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00267421Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00267423Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00287113Trichuris murisFrom_analysisWormBase-Compara
WBGene00296228Trichuris murisFrom_analysisWormBase-Compara
SGD:S000001121Saccharomyces cerevisiaeFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoFinder
OrthoInspector
Panther
SonicParanoid
FB:FBgn0261984Drosophila melanogasterFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-050522-431Danio rerioFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
Panther
SonicParanoid
ZFIN:ZDB-GENE-090312-15Danio rerioFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:3449Homo sapiensFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
Panther
PhylomeDB
SonicParanoid
HGNC:16942Homo sapiensFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:1349436Mus musculusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:1930134Mus musculusFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:1308743Rattus norvegicusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:1559716Rattus norvegicusFrom_analysisHieranoid
Inparanoid
OMA
OrthoFinder
Panther
PhylomeDB
SonicParanoid
Structured_descriptionConcise_descriptionire-1 encodes a transmembrane serine/threonine protein kinase and site-specific endoribonuclease orthologous to Saccharomyces cerevisiae inositol-requiring 1 protein kinase (Ire1) and human endoplasmic reticulum-to-nucleus signaling 1 (ERN1, OMIM:604033); IRE-1 is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); in response to ER stress, IRE-1 cleaves xbp-1 mRNA to produce transcriptionally active XBP-1 that positively regulates UPR gene expression in order to maintain ER homeostasis.Paper_evidenceWBPaper00005036
WBPaper00005044
WBPaper00005432
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables RNA endonuclease activity. Involved in nematode larval development; response to endoplasmic reticulum stress; and response to hypoxia. Acts upstream of with a positive effect on IRE1-mediated unfolded protein response and intrinsic apoptotic signaling pathway by p53 class mediator. Located in neuronal cell body. Expressed widely. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and oropharynx cancer. Is an ortholog of human ERN2 (endoplasmic reticulum to nucleus signaling 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:684Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3449)
DOID:8557Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:3449)
Molecular_infoCorresponding_CDSC41C4.4a
C41C4.4b
Corresponding_CDS_historyC41C4.4:wp111
Corresponding_transcriptC41C4.4a.1
C41C4.4b.1
Other_sequence (32)
Associated_feature (18)
Gene_product_bindsWBsf977530
Experimental_infoRNAi_result (44)
Expr_patternExpr3423
Expr1014693
Expr1031261
Expr1146268
Expr2012815
Expr2031054
Drives_constructWBCnstr00011391
WBCnstr00036417
Construct_productWBCnstr00036417
Microarray_results (21)
Expression_cluster (119)
Interaction (259)
WBProcess (4)
Map_infoMapIIPosition0.681931Error0.002224
PositivePositive_cloneC41C4Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Pseudo_map_position
Reference (124)
RemarkSequence connection from [Ron D]. krb 14/11/01
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene