WormBase Tree Display for Gene: WBGene00000939

WBGene00000939 Evidence: Paper_evidence: WBPaper00004772
  SMap: S_parent: Sequence: K12H4
  Identity: Version: 1
    Name: CGC_name: dcr-1 Person_evidence: WBPerson419
      Sequence_name: K12H4.8
      Molecular_name: K12H4.8
        K12H4.8.1
        CE47418
      Other_name: let-740 CGC_data_submission
        eri-4 Paper_evidence: WBPaper00035199
        CELE_K12H4.8 Accession_evidence: NDB BX284603
      Public_name: dcr-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:22 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: dcr
    Allele (78)
    Legacy_information: Homozygous s2624 and s2795 each develope into sterile adults.
    Strain (13)
    RNASeq_FPKM (74)
    GO_annotation (61)
    Ortholog: WBGene00096444 Pristionchus pacificus From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00061842 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00041414 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00150873 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00137823 Caenorhabditis japonica From_analysis: TreeFam
            WormBase-Compara
      WBGene00137516 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
      WBGene00225287 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g4851 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g5807 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g5622 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g8505 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g16741 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g10940 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g14858 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g18900 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g26929 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g4707 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g14647 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00358.g9698 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_03784.g18372 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_09575.g22148 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_12716.g23898 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-dcr-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g14499 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00699.g14549 Caenorhabditis sinica From_analysis: WormBase-Compara
      Csp5_scaffold_00916.g16720 Caenorhabditis sinica From_analysis: WormBase-Compara
      Csp5_scaffold_05034.g34265 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_21425 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_008291 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g04754 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g20904 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g24193 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_30052800 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIII_pilon.g8300 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00136752 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00178701 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00245211 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00259250 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00291969 Trichuris muris From_analysis: WormBase-Compara
      WBGene00294834 Trichuris muris From_analysis: WormBase-Compara
      WBGene00295724 Trichuris muris From_analysis: WormBase-Compara
      WBGene00295899 Trichuris muris From_analysis: WormBase-Compara
      WBGene00296359 Trichuris muris From_analysis: WormBase-Compara
      WBGene00296416 Trichuris muris From_analysis: WormBase-Compara
      WBGene00297023 Trichuris muris From_analysis: WormBase-Compara
      WBGene00297151 Trichuris muris From_analysis: WormBase-Compara
      WBGene00297152 Trichuris muris From_analysis: WormBase-Compara
      WBGene00297692 Trichuris muris From_analysis: WormBase-Compara
      WBGene00297699 Trichuris muris From_analysis: WormBase-Compara
      WBGene00298482 Trichuris muris From_analysis: WormBase-Compara
      WBGene00298995 Trichuris muris From_analysis: WormBase-Compara
      WBGene00299171 Trichuris muris From_analysis: WormBase-Compara
      WBGene00301051 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0039016 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-030131-3445 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:17098 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:2177178 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1309381 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog: WBGene00001090 Caenorhabditis elegans From_analysis: TreeFam
      WBGene00008400 Caenorhabditis elegans From_analysis: TreeFam
    Structured_description: Concise_description: dcr-1 encodes a bidentate ribonuclease that is homologous to E. coli RNAse III; DCR-1 is required both for RNA interference and for synthesis of small developmental RNAs; DCR-1 functions to process pre-miRNAs into their mature, 22-nt form; DCR-1 interacts in vivo with RDE-4, a double-stranded RNA (dsRNA) binding protein required for RNAi that interacts with trigger dsRNAs and may function to deliver dsRNAs to DCR-1 for endonucleolytic processing; DCR-1 is also required for fragmention of chromosomal DNA during apoptosis, and undergoes a CED-3 protease-mediated conversion from a ribonuclease to a deoxyribonuclease. Paper_evidence: WBPaper00004424
            WBPaper00004923
            WBPaper00005368
            WBPaper00036025
            WBPaper00024573
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 03 Feb 2014 00:00:00
      Automated_description: Enables deoxyribonuclease I activity and ribonuclease III activity. Involved in several processes, including nucleic acid metabolic process; olfactory learning; and positive regulation of primary miRNA processing. Acts upstream of or within defense response to Gram-positive bacterium. Located in cytosol and nucleus. Expressed in germ line; intestine; neurons; and somatic cell. Human ortholog(s) of this gene implicated in several diseases, including DICER1 syndrome; gastrointestinal system cancer (multiple); and multinodular goiter. Is an ortholog of human DICER1 (dicer 1, ribonuclease III). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17098)
      DOID:4769 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17098)
      DOID:0050745 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17098)
      DOID:0080615 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17098)
      DOID:0050489 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17098)
      DOID:10534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17098)
      DOID:0081063 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17098)
      DOID:684 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17098)
  Molecular_info: Corresponding_CDS: K12H4.8
    Corresponding_CDS_history: K12H4.8:wp230
    Corresponding_transcript: K12H4.8.1
    Other_sequence (58)
    Associated_feature: WBsf651241
      WBsf667129
      WBsf227077
      WBsf227078
  Experimental_info: RNAi_result (65)
    Expr_pattern: Expr10581
      Expr11565
      Expr12215
      Expr12472
      Expr1022725
      Expr1030586
      Expr1154395
      Expr2010807
      Expr2029044
    Drives_construct: WBCnstr00005999
      WBCnstr00006000
      WBCnstr00006001
      WBCnstr00017007
      WBCnstr00020414
      WBCnstr00037186
    Construct_product (13)
    Regulate_expr_cluster: WBPaper00027057:DCR-1_interacting_adult
      WBPaper00027057:DCR-1_interacting_embryo
      WBPaper00029437:dcr-1_downregulated
      WBPaper00029437:dcr-1_upregulated
      WBPaper00059490:dcr-1(m9375)_downregulated
      WBPaper00059490:dcr-1(m9375)_upregulated
    Antibody: WBAntibody00000418
      WBAntibody00001054
      WBAntibody00001326
      WBAntibody00001327
      WBAntibody00001490
      WBAntibody00002257
      WBAntibody00002600
    Microarray_results (18)
    Expression_cluster (137)
    Interaction (219)
    WBProcess: WBbiopr:00000014
      WBbiopr:00000039
      WBbiopr:00000057
      WBbiopr:00000073
      WBbiopr:00000081
  Map_info: Map: III Position: -0.385999 Error: 0.003601
    Hide_under: WBGene00002843
    Positive: Inside_rearr: nDf20
        sDp3
        sDp8
      Positive_clone: K12H4 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Outside_rearr: sDf128
    Mapping_data (2)
  Reference (124)
  Remark: The let-740 gene is the same gene as dcr-1 and they therefore have been merged following advice from the CGC. let-740 is now an other name for dcr-1 [krb 030508]
  Method: Gene