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WormBase Tree Display for Gene: WBGene00006915

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Name Class

WBGene00006915SMapS_parentSequenceCHROMOSOME_II
IdentityVersion1
NameCGC_namevha-6
Sequence_nameVW02B12L.1
Molecular_nameVW02B12L.1
VW02B12L.1.1
CE18980
Other_nameCELE_VW02B12L.1Accession_evidenceNDBBX284602
Public_namevha-6
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:43WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classvha
Allele (54)
Legacy_information[Pujol N] vha-6 is expressed only in the intestine, from the embryonic coma stage through larvae and adult
StrainWBStrain00036524
RNASeq_FPKM (74)
GO_annotation (17)
OrthologWBGene00053565Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00024808Caenorhabditis briggsaeFrom_analysisOrthoMCL
WBGene00025861Caenorhabditis briggsaeFrom_analysisOrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00026344Caenorhabditis briggsaeFrom_analysisOrthoMCL
WBGene00029076Caenorhabditis briggsaeFrom_analysisOrthoMCL
WBGene00117953Pristionchus pacificusFrom_analysisOMA
WormBase-Compara
WBGene00195042Caenorhabditis brenneriFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00131539Caenorhabditis japonicaFrom_analysisInparanoid_8
WormBase-Compara
WBGene00104585Pristionchus pacificusFrom_analysisOMA
WBGene00230361Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g6988Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g1460Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g3745Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g1481Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g17312Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g1965Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g16241Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g12119Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g2707Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g17790Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_00674.g13345Caenorhabditis angariaFrom_analysisWormBase-Compara
Cang_2012_03_13_00674.g13346Caenorhabditis angariaFrom_analysisWormBase-Compara
Cni-vha-6Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold285.g739Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_00351.g9929Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_14188Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_005348Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g12585Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g15940Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_20330200Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrII_pilon.g5939Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00110806Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00205924Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00258603Strongyloides rattiFrom_analysisWormBase-Compara
WBGene00289220Trichuris murisFrom_analysisWormBase-Compara
SGD:S000005796Saccharomyces cerevisiaeFrom_analysisEnsEMBL-Compara
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
SGD:S000004658Saccharomyces cerevisiaeFrom_analysisEnsEMBL-Compara
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
FB:FBgn0032373Drosophila melanogasterFrom_analysisOrthoFinder
Panther
PhylomeDB
FB:FBgn0038613Drosophila melanogasterFrom_analysisOrthoFinder
Panther
PhylomeDB
FB:FBgn0028670Drosophila melanogasterFrom_analysisOrthoFinder
Panther
PhylomeDB
FB:FBgn0028671Drosophila melanogasterFrom_analysisOrthoFinder
Panther
PhylomeDB
FB:FBgn0028669Drosophila melanogasterFrom_analysisOrthoFinder
Panther
PhylomeDB
ZFIN:ZDB-GENE-040426-2022Danio rerioFrom_analysisOrthoFinder
Panther
PhylomeDB
ZFIN:ZDB-GENE-050522-215Danio rerioFrom_analysisOrthoFinder
Panther
PhylomeDB
ZFIN:ZDB-GENE-060526-4Danio rerioFrom_analysisOrthoFinder
Panther
PhylomeDB
ZFIN:ZDB-GENE-091113-4Danio rerioFrom_analysisOrthoFinder
Panther
PhylomeDB
ZFIN:ZDB-GENE-090311-31Danio rerioFrom_analysisOrthoFinder
Panther
PhylomeDB
ZFIN:ZDB-GENE-141212-282Danio rerioFrom_analysisOrthoFinder
Panther
PhylomeDB
HGNC:865Homo sapiensFrom_analysisOrthoFinder
Panther
PhylomeDB
HGNC:11647Homo sapiensFrom_analysisOrthoFinder
Panther
PhylomeDB
HGNC:18481Homo sapiensFrom_analysisOrthoFinder
Panther
PhylomeDB
HGNC:866Homo sapiensFrom_analysisOrthoFinder
Panther
PhylomeDB
MGI:103286Mus musculusFrom_analysisOrthoFinder
Panther
PhylomeDB
MGI:104855Mus musculusFrom_analysisOrthoFinder
Panther
PhylomeDB
MGI:2153480Mus musculusFrom_analysisOrthoFinder
Panther
PhylomeDB
RGD:68405Rattus norvegicusFrom_analysisOrthoFinder
Panther
PhylomeDB
RGD:735136Rattus norvegicusFrom_analysisOrthoFinder
Panther
PhylomeDB
RGD:1305055Rattus norvegicusFrom_analysisOrthoFinder
Panther
PhylomeDB
ParalogWBGene00006768Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006914Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006916Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionvha-6 encodes an ortholog of subunit a of the membrane-bound (V0) domainof vacuolar proton-translocating ATPase (V-ATPase); VHA-6 is orthologousto human ATP6N1A (OMIM:192130), ATP6V0A2, ATP6V0A4 (OMIM:605239, mutatedin distal renal tubular acidosis), and TCIRG1 (OMIM:604592, mutated inosteopetrosis); VHA-6 is expressed in germline (P2 through Z3 cellsuntil the comma stage), on the apical surface of postembryonicintestinal cells, and at the junction between pharynx and intestine;VHA-6 is required for growth and survival past the L1 larval stage;vha-6(RNAi) animals arrest as L1 larvae and remain alive (but do notgrow) for one week; in S. cerevisiae, different V0 a-subunits (Stv1p andVph1p) direct the assembly of V-ATPases to different membranes andorganelles, suggesting that the profusion of such subunits in C. elegans(co-orthologous VHA-5, VHA-6, VHA-7, and six UNC-32 isoforms) may have asimilar function; VHA-6 is predicted to capture protons from V-ATPasetransmembrane rotor components and export the protons across themembrane.Paper_evidenceWBPaper00004601
WBPaper00004842
WBPaper00025183
WBPaper00028773
WBPaper00028774
WBPaper00028775
Curator_confirmedWBPerson567
Date_last_updated19 Nov 2006 00:00:00
Automated_descriptionPredicted to enable ATPase binding activity. Involved in nematode larval development. Located in apical plasma membrane. Part of vacuolar proton-transporting V-type ATPase complex. Expressed in Psub2; excretory cell; hypodermis; pharyngeal-intestinal valve; and uterus. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive cutis laxa type IIA; autosomal recessive osteopetrosis 1; and developmental and epileptic encephalopathy 104. Is an ortholog of several human genes including ATP6V0A1 (ATPase H+ transporting V0 subunit a1); ATP6V0A2 (ATPase H+ transporting V0 subunit a2); and TCIRG1 (T cell immune regulator 1, ATPase H+ transporting V0 subunit a3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0070390Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:865)
DOID:0110942Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11647)
DOID:14219Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:866)
DOID:0112171Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:18481)
EFO:MONDO:0015827Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:866)
DOID:0070134Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:18481)
Molecular_infoCorresponding_CDSVW02B12L.1
Corresponding_transcriptVW02B12L.1.1
Other_sequence (71)
Associated_featureWBsf650573
WBsf650574
WBsf989758
WBsf1013237
WBsf223933
Experimental_infoRNAi_result (55)
Expr_patternExpr851
Expr2404
Expr2407
Expr13465
Expr1029215
Expr1032932
Expr1158019
Expr2017992
Expr2036128
Drives_construct (205)
Construct_productWBCnstr00013297
WBCnstr00016253
WBCnstr00038389
AntibodyWBAntibody00000406
Microarray_results (20)
Expression_cluster (230)
Interaction (123)
Map_infoMapIIPosition3.46558Error0.000297
PositivePositive_cloneVW02B12LInferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00004842
WBPaper00005295
WBPaper00005567
WBPaper00010347
WBPaper00029254
WBPaper00034480
WBPaper00035048
WBPaper00035182
WBPaper00036098
WBPaper00036578
WBPaper00036659
WBPaper00038491
WBPaper00046899
WBPaper00055090
WBPaper00057684
WBPaper00058161
WBPaper00058835
WBPaper00058870
WBPaper00059755
WBPaper00061730
WBPaper00062454
WBPaper00064023
WBPaper00064130
WBPaper00064187
WBPaper00064204
WBPaper00064229
WBPaper00064708
WBPaper00064933
RemarkSequence From: Pujol Nathalie via ACEDB feedback page <pujol@lgpd.univ-mrs.fr>
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene