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WormBase Tree Display for Gene: WBGene00001689

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Name Class

WBGene00001689EvidenceCGC_data_submission
SMapS_parentSequenceC38C10
IdentityVersion1
NameCGC_namegpr-2Person_evidenceWBPerson732
Sequence_nameC38C10.4
Molecular_nameC38C10.4
C38C10.4.1
CE00107
Other_nameags-3.3
lap-1/ags-3.3Paper_evidenceWBPaper00010166
CELE_C38C10.4Accession_evidenceNDBBX284603
Public_namegpr-2
DB_infoDatabaseAceViewgene3K482
WormQTLgeneWBGene00001689
WormFluxgeneWBGene00001689
NDBlocus_tagCELE_C38C10.4
NCBIgene176318
RefSeqproteinNM_066665.8
SwissProtUniProtAccQ03569
TREEFAMTREEFAM_IDTF318159
UniProt_GCRPUniProtAccQ03569
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:25WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classgpr
Allele (23)
StrainWBStrain00031852
WBStrain00034750
RNASeq_FPKM (74)
GO_annotation (11)
Contained_in_operonCEOP3576
OrthologWBGene00055111Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00031578Caenorhabditis briggsaeFrom_analysisOrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00159324Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00208756Caenorhabditis japonicaFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
CBOVI.g6869Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP26.g5714Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g20084Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g3292Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g19422Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g11377Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g5620Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g5620Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g3350Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cni-slc-17.2Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold629.g9374Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_01114.g18490Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_07424Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_009419Caenorhabditis remaneiFrom_analysisWormBase-Compara
Sp34_30269300Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrIII_pilon.g8602Caenorhabditis elegansFrom_analysisWormBase-Compara
ParalogWBGene00001688Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
Structured_descriptionConcise_descriptiongpr-2 encodes a protein containing a GPR (G Protein Regulator)/GoLoco motif characteristic of guanine nucleotide exchange factors specific for G-alpha GTPases; GPR-2 appears to function redundantly during early embryogenesis and germ-line development to regulate chromosome and spindle movements during cell division; GPR-2 likely acts as a positive regulator of G protein signaling and specifically, may regulate GOA-1 signaling in the embryo; GPR-2 forms a protein complex with the nearly identical GPR-1 and with LIN-5, a coiled-coil protein that is required for proper localization of GPR-2 to the cell cortex and spindle asters of the early embryo; in addition, proper GPR-2/GPR-1/LIN-5 localization between the P2 and EMS blastomeres at the four-cell stage, which may contribute to spindle positioning in EMS, requires the MES-1/SRC-1 tyrosine kinase signaling pathway; GPR-2 is believed to act downstream of, or in parallel to, PAR-3, a PDZ domain-containing protein, in mitotic spindle positioning in the early embryo.Paper_evidenceWBPaper00005405
WBPaper00005878
WBPaper00017879
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionEnables GDP-dissociation inhibitor activity. Predicted to be involved in cell division. Located in aster and cell cortex. Expressed in P lineage cell.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSC38C10.4
Corresponding_transcriptC38C10.4.1
Other_sequenceCBC07136_1
Associated_featureWBsf655471
WBsf227280
WBsf227281
Experimental_infoRNAi_result (55)
Expr_patternExpr2564
Expr10765
Expr1013915
Expr1031008
Expr1146135
Expr1200200
Expr2012214
Expr2030450
Drives_constructWBCnstr00036767
Construct_productWBCnstr00010004
WBCnstr00019267
WBCnstr00036767
AntibodyWBAntibody00000624
WBAntibody00000631
WBAntibody00000632
WBAntibody00000648
WBAntibody00000701
WBAntibody00000783
WBAntibody00000790
WBAntibody00001312
WBAntibody00001392
Microarray_results (11)
Expression_cluster (126)
Interaction (58)
WBProcessWBbiopr:00000017
Map_infoMapIIIPosition0.469922Error0.005225
PositivePositive_cloneC38C10Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00005317
WBPaper00005405
WBPaper00005878
WBPaper00005880
WBPaper00005918
WBPaper00005945
WBPaper00005985
WBPaper00006121
WBPaper00006289
WBPaper00006320
WBPaper00010166
WBPaper00010344
WBPaper00017725
WBPaper00017879
WBPaper00019348
WBPaper00024244
WBPaper00024449
WBPaper00024543
WBPaper00024864
WBPaper00025100
WBPaper00026807
WBPaper00026922
WBPaper00027230
WBPaper00027672
WBPaper00028765
WBPaper00028955
WBPaper00029025
WBPaper00029190
WBPaper00029322
WBPaper00030799
WBPaper00030892
WBPaper00031062
WBPaper00031073
WBPaper00031168
WBPaper00031354
WBPaper00031475
WBPaper00031652
WBPaper00031928
WBPaper00032096
WBPaper00032337
WBPaper00032910
WBPaper00033032
WBPaper00033077
WBPaper00035112
WBPaper00035559
WBPaper00036019
WBPaper00038085
WBPaper00038698
WBPaper00040003
WBPaper00040078
WBPaper00040112
WBPaper00040172
WBPaper00041486
WBPaper00042820
WBPaper00045425
WBPaper00046208
WBPaper00047056
WBPaper00048917
WBPaper00050212
WBPaper00052847
WBPaper00055155
WBPaper00055830
WBPaper00061021
WBPaper00061344
RemarkSequence connection from [Ahringer JA]
Gene renamed from ags-3.3 to gpr-2 following advice from [Hodgkin J], [020808 krb]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene