WormBase Tree Display for Gene: WBGene00002215
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WBGene00002215 | SMap | S_parent | Sequence | C18C4 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | klc | ||||||
Allele (67) | |||||||
Legacy_information | [Siddiqui SS ] Predicted gene C18C4.10. Related to kinesin light chain by sequence similarity. | ||||||
Strain (2) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (32) | |||||||
Ortholog (58) | |||||||
Paralog | WBGene00002214 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
Structured_description | Concise_description | klc-2 encodes a kinesin light chain; klc-2 is required for transport and localization of synaptic vesicles to presynaptic terminals; in addition, klc-2 is required for normal translocation of the meiotic spindle to the oocyte cortex; KLC-2 physically interacts with UNC-116/kinesin heavy chain (KHC) and with UNC-16 and UNC-14, suggesting that it regulates vesicular transport by mediating the association between UNC-116/KHC and synaptic vesicles; a KLC-2::GFP fusion protein is widely expressed and seen in neurons, muscle, and the pharynx; in neurons, KLC-2::GFP exhibits diffuse localization. | Paper_evidence | WBPaper00004211 | |||
WBPaper00005014 | |||||||
WBPaper00005076 | |||||||
WBPaper00024617 | |||||||
WBPaper00025176 | |||||||
WBPaper00026866 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson324 | |||||||
Date_last_updated | 13 Mar 2009 00:00:00 | ||||||
Automated_description | Enables kinesin binding activity. Involved in several processes, including axon extension; establishment of organelle localization; and polar body extrusion after meiotic divisions. Located in cytoplasm and nuclear envelope. Part of kinesin I complex. Expressed in body ganglion; muscle cell; pharynx; and somatic nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; SPOAN syndrome; and relapsing-remitting multiple sclerosis. Is an ortholog of human KLC1 (kinesin light chain 1) and KLC2 (kinesin light chain 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||
Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6387) | ||
DOID:2378 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6387) | ||||
DOID:0060491 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20716) | ||||
Molecular_info | Corresponding_CDS | C18C4.10a | |||||
C18C4.10b | |||||||
C18C4.10c | |||||||
Corresponding_CDS_history | C18C4.10b:wp90 | ||||||
C18C4.10d:wp261 | |||||||
Corresponding_transcript | C18C4.10a.1 | ||||||
C18C4.10b.1 | |||||||
C18C4.10b.2 | |||||||
C18C4.10b.3 | |||||||
C18C4.10c.1 | |||||||
Other_sequence (99) | |||||||
Associated_feature (19) | |||||||
Experimental_info | RNAi_result (12) | ||||||
Expr_pattern (9) | |||||||
Drives_construct | WBCnstr00002469 | ||||||
WBCnstr00036381 | |||||||
Construct_product | WBCnstr00036381 | ||||||
Antibody | WBAntibody00001660 | ||||||
WBAntibody00002831 | |||||||
Microarray_results (43) | |||||||
Expression_cluster (139) | |||||||
Interaction (91) | |||||||
Map_info | Map | V | Position | -1.48452 | Error | 0.026086 | |
Positive | Positive_clone | C18C4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 4462 | |||||
4944 | |||||||
5254 | |||||||
Pseudo_map_position | |||||||
Reference (36) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |