klc-2 encodes a kinesin light chain; klc-2 is required for transport and localization of synaptic vesicles to presynaptic terminals; in addition, klc-2 is required for normal translocation of the meiotic spindle to the oocyte cortex; KLC-2 physically interacts with UNC-116/kinesin heavy chain (KHC) and with UNC-16 and UNC-14, suggesting that it regulates vesicular transport by mediating the association between UNC-116/KHC and synaptic vesicles; a KLC-2::GFP fusion protein is widely expressed and seen in neurons, muscle, and the pharynx; in neurons, KLC-2::GFP exhibits diffuse localization.
Enables kinesin binding activity. Involved in several processes, including axon extension; establishment of organelle localization; and polar body extrusion after meiotic divisions. Located in cytoplasm and nuclear envelope. Part of kinesin I complex. Expressed in body ganglion; muscle cell; pharynx; and somatic nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; SPOAN syndrome; and relapsing-remitting multiple sclerosis. Is an ortholog of human KLC1 (kinesin light chain 1) and KLC2 (kinesin light chain 2).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.