WormBase Tree Display for Gene: WBGene00004995
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WBGene00004995 | Evidence | Author_evidence | Patthy L | ||||||
---|---|---|---|---|---|---|---|---|---|
Hodgkin JA | |||||||||
SMap | S_parent | Sequence | C28C12 | ||||||
Identity | Version | 1 | |||||||
Name (5) | |||||||||
DB_info | Database (11) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | spp | ||||||||
Allele (45) | |||||||||
Strain | WBStrain00032093 | ||||||||
WBStrain00036036 | |||||||||
WBStrain00036070 | |||||||||
WBStrain00036142 | |||||||||
WBStrain00036210 | |||||||||
WBStrain00036330 | |||||||||
WBStrain00036673 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation | 00113407 | ||||||||
00113408 | |||||||||
00113409 | |||||||||
Ortholog (48) | |||||||||
Paralog | WBGene00004992 | Caenorhabditis elegans | From_analysis | Panther | |||||
WormBase-Compara | |||||||||
WBGene00004993 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
WBGene00004998 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WBGene00005000 | Caenorhabditis elegans | From_analysis | Panther | ||||||
Structured_description | Concise_description | spp-10 encodes two protein isoforms that are orthologous to the human gene PROSAPOSIN (PSAP; OMIM:176801, mutated in Gaucher disease and metachromatic leukodystrophy); SPP-10A and -10B are predicted to have 3 and 4 embedded saposin sequences, that are likely to be split into individual saposin peptides by proteolysis; in mammals, saposins activate the enzymes sphingomyelinphosphodiesterase and beta-glucosylceramidase; spp-10 has no obvious function in mass RNAi assays. | Paper_evidence | WBPaper00013533 | |||||
Curator_confirmed | WBPerson1823 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
Automated_description | Predicted to be involved in sphingolipid metabolic process. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in several diseases, including cystic fibrosis; lung disease (multiple); and sphingolipidosis (multiple). Is an ortholog of human PSAP (prosaposin) and PSAPL1 (prosaposin like 1). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model (22) | ||||||||
Molecular_info | Corresponding_CDS | C28C12.7a | |||||||
C28C12.7b | |||||||||
Corresponding_transcript | C28C12.7a.1 | ||||||||
C28C12.7b.1 | |||||||||
Other_sequence (32) | |||||||||
Associated_feature | WBsf646166 | ||||||||
WBsf718141 | |||||||||
WBsf997226 | |||||||||
WBsf228682 | |||||||||
WBsf228683 | |||||||||
WBsf228684 | |||||||||
Experimental_info | RNAi_result | WBRNAi00011295 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00041403 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00011296 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00075913 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00041404 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00029297 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr5367 | ||||||||
Expr1019104 | |||||||||
Expr1032485 | |||||||||
Expr1145434 | |||||||||
Expr2016065 | |||||||||
Expr2034301 | |||||||||
Drives_construct | WBCnstr00003963 | ||||||||
WBCnstr00035283 | |||||||||
Construct_product | WBCnstr00035283 | ||||||||
Microarray_results | SMD_C28C12.6 | ||||||||
SMD_C28C12.7 | |||||||||
173276_s_at | |||||||||
185898_at | |||||||||
185955_at | |||||||||
A_12_P100923 | |||||||||
A_12_P138565 | |||||||||
A_12_P138566 | |||||||||
Aff_C28C12.6 | |||||||||
Aff_C28C12.7 | |||||||||
GPL13394_WBGene00004995 | |||||||||
GPL13914_C28C12.7 | |||||||||
GPL14144_C28C12.7b_171-230_0.857_39_C | |||||||||
GPL14144_C28C12.7b_322-381_0.886_20_A | |||||||||
GPL14144_C28C12.7b_429-488_0.863_32_B | |||||||||
GPL19516_CGZ0006455 | |||||||||
GPL19516_CGZ0006456 | |||||||||
GPL21109_C28C12.7a | |||||||||
GPL21109_C28C12.7b | |||||||||
GPL3518_CE29486 | |||||||||
GPL8304_CE_WBGene00004995_A | |||||||||
GPL8304_CE_WBGene00004995_B | |||||||||
GPL8304_CE_WBGene00004995_C | |||||||||
GPL8673_C28C12_7aP00059 | |||||||||
GPL8673_C28C12_7aP00476 | |||||||||
GPL8673_C28C12_7aP00594 | |||||||||
GPL8673_C28C12_7bP00728 | |||||||||
GPL8673_C28C12_7bP00967 | |||||||||
GPL8673_C28C12_7bP01231 | |||||||||
GPL9450_C28C12.7a | |||||||||
GPL9450_C28C12.7b | |||||||||
cea2.c.26547 | |||||||||
cea2.d.07788 | |||||||||
Expression_cluster (185) | |||||||||
Interaction (17) | |||||||||
Map_info | Map | IV | Position | 3.83716 | Error | 0.002099 | |||
Positive | Positive_clone | C28C12 | Inferred_automatically | From CDS info | |||||
From sequence, transcript, pseudogene data | |||||||||
Mapping_data | Multi_point | 5118 | |||||||
Pseudo_map_position | |||||||||
Reference | WBPaper00024209 | ||||||||
WBPaper00025032 | |||||||||
WBPaper00025088 | |||||||||
WBPaper00025190 | |||||||||
WBPaper00038491 | |||||||||
WBPaper00048489 | |||||||||
WBPaper00055090 | |||||||||
WBPaper00065937 | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |