WormBase Tree Display for Gene: WBGene00003931
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WBGene00003931 | Evidence | CGC_data_submission | |||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | CHROMOSOME_III | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | pat | ||||||
Allele (312) | |||||||
Legacy_information | [Williams DB] Severe Pat phenotype, all alleles similar | ||||||
[C.elegansII] st552 : severe Pat phenotype. OA3: st551, st579, st580 (all similar). [Williams and Waterston 1994; RW] | |||||||
[MacKinnon C] Predicted gene C29F9.7, encoding homologue of vertebrate integrin-linked kinase | |||||||
Strain | WBStrain00002637 | ||||||
WBStrain00033521 | |||||||
WBStrain00040330 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (46) | |||||||
Ortholog (34) | |||||||
Paralog (11) | |||||||
Structured_description | Concise_description | The pat-4 gene encodes a serine/threonine kinase orthologous to human integrin-linked kinase (ILK, OMIM:602366) and is required for formation of integrin-mediated muscle cell attachments during embryogenesis; PAT-4 probably functions as an adaptor molecule and localizes to dense bodies and M lines; PAT-4 forms a ternary complex with PAT-6/actopaxin and UNC-112, and requires UNC-112, UNC-52/perlecan, PAT-2/alpha integrin, and PAT-3/beta integrin for proper localization to newly forming integrin adhesion complexes. | Paper_evidence | WBPaper00005261 | |||
WBPaper00005915 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Enables integrin binding activity and protein-macromolecule adaptor activity. Involved in several processes, including integrin-mediated signaling pathway; organelle organization; and positive regulation of supramolecular fiber organization. Located in adherens junction; basal plasma membrane; and contractile fiber. Part of integrin complex. Expressed in body wall musculature; gonad; non-striated muscle; pharynx; and touch receptor neurons. Human ortholog(s) of this gene implicated in ovarian cancer; pancreatic cancer; and prostate adenocarcinoma. Is an ortholog of human ILK (integrin linked kinase). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6040) | ||
DOID:1793 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6040) | ||||
DOID:2526 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6040) | ||||
DOID:2394 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6040) | ||||
Molecular_info | Corresponding_CDS | C29F9.7 | |||||
Corresponding_transcript | C29F9.7.1 | ||||||
Other_sequence (89) | |||||||
Associated_feature | WBsf990981 | ||||||
WBsf226082 | |||||||
WBsf226083 | |||||||
Experimental_info | RNAi_result (40) | ||||||
Expr_pattern | Chronogram438 | ||||||
Expr1888 | |||||||
Expr5379 | |||||||
Expr11437 | |||||||
Expr14519 | |||||||
Expr1010218 | |||||||
Expr1031864 | |||||||
Expr1145524 | |||||||
Expr2014752 | |||||||
Expr2032986 | |||||||
Drives_construct | WBCnstr00003184 | ||||||
WBCnstr00010504 | |||||||
WBCnstr00021447 | |||||||
WBCnstr00041071 | |||||||
Construct_product | WBCnstr00010504 | ||||||
WBCnstr00019202 | |||||||
WBCnstr00021626 | |||||||
WBCnstr00021697 | |||||||
WBCnstr00041071 | |||||||
Antibody | WBAntibody00000510 | ||||||
WBAntibody00002369 | |||||||
Microarray_results | SMD_C29F9.7 | ||||||
173317_s_at | |||||||
192374_s_at | |||||||
A_12_P118486 | |||||||
Aff_C29F9.7 | |||||||
GPL13394_WBGene00003931 | |||||||
GPL13914_C29F9.7 | |||||||
GPL14144_C29F9.7_1029-1088_0.933_1_C | |||||||
GPL14144_C29F9.7_693-752_0.880_9_A | |||||||
GPL14144_C29F9.7_854-913_0.832_33_B | |||||||
GPL19516_CGZ0006660 | |||||||
GPL21109_C29F9.7 | |||||||
GPL3518_CE19706 | |||||||
GPL8304_CE_WBGene00003931_A | |||||||
GPL8673_C29F9_7P00004 | |||||||
GPL8673_C29F9_7P00632 | |||||||
GPL8673_C29F9_7P01084 | |||||||
GPL9450_C29F9.7 | |||||||
cea2.p.58793 | |||||||
Expression_cluster (141) | |||||||
Interaction (83) | |||||||
WBProcess | WBbiopr:00000006 | ||||||
Map_info | Map | III | Position | -26.9858 | Error | 0.037333 | |
Well_ordered | |||||||
Positive | Positive_clone | C29F9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 3016 | |||||
3017 | |||||||
Reference (49) | |||||||
Remark | Data extracted from Williams & Waterston 1994 | ||||||
Sequence connection from [Rogalski TM, Williams BD] | |||||||
Method | Gene |