stau-1 encodes a double-stranded RNA (dsRNA)-binding protein orthologous to Drosophila Staufen and mammalian STAU1 and STAU2; STAU-1 binds dsRNA in vitro, showing preference for highly structured RNAs; genetic analyses suggest that stau-1 activity is required for regulation of gene expression, RNA interference, and, along with eri-1, germ cell development; STAU-1 is expressed at all developmental stages, with highest levels seen in embryos.
Enables double-stranded RNA binding activity. Involved in germ cell development and negative regulation of post-transcriptional gene silencing by regulatory ncRNA. Predicted to be located in several cellular components, including cytoplasmic stress granule; neuron projection; and neuronal cell body. Predicted to be part of messenger ribonucleoprotein complex. Human ortholog(s) of this gene implicated in atherosclerosis. Is an ortholog of human STAU1 (staufen double-stranded RNA binding protein 1).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.