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WormBase Tree Display for Gene: WBGene00018811

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Name Class

WBGene00018811SMapS_parentSequenceF54D11
IdentityVersion2
NameCGC_namepmt-2Person_evidenceWBPerson888
Sequence_nameF54D11.1
Molecular_nameF54D11.1
F54D11.1.1
CE11068
Other_nameCELE_F54D11.1Accession_evidenceNDBBX284605
Public_namepmt-2
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change128 May 2004 13:31:00WBPerson1971EventImportedInitial conversion from CDS class of stlace from WS125
219 May 2006 11:42:44WBPerson2970Name_changeCGC_namepmt-2
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classpmt
Allele (90)
StrainWBStrain00036988
RNASeq_FPKM (74)
GO_annotation (14)
Ortholog (39)
ParalogWBGene00044310Caenorhabditis elegansFrom_analysisPanther
WBGene00000765Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00008743Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00015450Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00019198Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00019675Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00019961Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00019963Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00019968Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00022781Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionpmt-2 encodes an experimentally validated N-methyltransferase required for phosphocholine biosynthesis and viability; PMT-2 lacks known mammalian orthologs, but has orthologs in parasitic nematodes, fish, amphibians, echinoderms, plants, alveolata, and bacteria; PMT-2 is distantly paralogous to PMT-1; PMT-2 has a single C-terminal methyltransferase domain, unlike plant enzymes that have two tandem domains, and catalyses only two of three steps in phosphocholine biosynthesis (methylation of phosphomonomethylethanolamine [P-MME] to phosphodimethylethanolamine [P-DME] and of P-DME to phosphocholine, but not methylation of phosphoethanolamine to P-MME); pmt-2(RNAi) animals are unable to progress past the L1 larval stage, but can be rescued by choline in their food media; PMT-2 binds its substrates in random order, and is competitively inhibited by phosphocholine; given its phylogenetic and enzymatic specificity, coupled with its inviable RNAi phenotype, PMT-1 is a plausible target for nematicides.Paper_evidenceWBPaper00027622
WBPaper00029127
Curator_confirmedWBPerson567
Date_last_updated24 Jul 2007 00:00:00
Automated_descriptionEnables phosphatidyl-N-dimethylethanolamine N-methyltransferase activity and phosphatidyl-N-methylethanolamine N-methyltransferase activity. Involved in phosphatidylcholine biosynthetic process. Is an ortholog of human TMT1A (thiol methyltransferase 1A) and TMT1B (thiol methyltransferase 1B).Paper_evidenceWBPaper00065943
Curator_confirmed (2)
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSF54D11.1
Corresponding_transcriptF54D11.1.1
Other_sequence (76)
Associated_featureWBsf646766
WBsf999839
WBsf999840
WBsf1019526
WBsf1019527
WBsf231676
WBsf231677
Experimental_infoRNAi_resultWBRNAi00112534Inferred_automaticallyRNAi_primary
WBRNAi00117411Inferred_automaticallyRNAi_primary
WBRNAi00117409Inferred_automaticallyRNAi_primary
WBRNAi00117407Inferred_automaticallyRNAi_primary
WBRNAi00048294Inferred_automaticallyRNAi_primary
WBRNAi00084628Inferred_automaticallyRNAi_primary
WBRNAi00117405Inferred_automaticallyRNAi_primary
WBRNAi00084627Inferred_automaticallyRNAi_primary
WBRNAi00084630Inferred_automaticallyRNAi_primary
WBRNAi00084629Inferred_automaticallyRNAi_primary
Expr_patternExpr1028910
Expr1038113
Expr1152094
Expr2014980
Expr2033215
Regulate_expr_clusterWBPaper00055482:pmt-2(RNAi)_downregulated
WBPaper00055482:pmt-2(RNAi)_upregulated
Microarray_results (20)
Expression_cluster (244)
InteractionWBInteraction000143843
WBInteraction000163113
WBInteraction000172730
WBInteraction000177009
WBInteraction000179050
WBInteraction000179217
WBInteraction000179324
WBInteraction000183734
WBInteraction000183960
WBInteraction000191107
WBInteraction000197762
WBInteraction000199838
WBInteraction000200773
WBInteraction000204963
WBInteraction000206213
WBInteraction000206251
WBInteraction000209446
WBInteraction000214860
WBInteraction000217216
WBInteraction000222993
WBInteraction000223511
WBInteraction000226550
WBInteraction000228633
WBInteraction000231544
WBInteraction000232845
WBInteraction000232990
WBInteraction000235480
WBInteraction000240111
WBInteraction000244581
WBInteraction000250498
WBInteraction000250720
WBInteraction000251616
WBInteraction000252539
WBInteraction000261223
WBInteraction000266954
WBInteraction000271013
WBInteraction000279127
WBInteraction000279904
WBInteraction000287048
WBInteraction000287858
WBInteraction000289758
WBInteraction000290068
WBInteraction000291477
WBInteraction000293175
WBInteraction000294535
WBInteraction000296704
WBInteraction000297457
WBInteraction000303875
WBInteraction000306370
WBInteraction000311341
WBInteraction000322395
WBInteraction000324639
WBInteraction000339064
WBInteraction000340415
WBInteraction000353756
WBInteraction000353805
WBInteraction000355181
WBInteraction000369945
WBInteraction000370960
WBInteraction000373128
WBInteraction000378895
WBInteraction000379427
WBInteraction000381144
WBInteraction000383540
WBInteraction000396185
WBInteraction000396300
WBInteraction000399652
WBInteraction000400731
WBInteraction000401982
WBInteraction000405484
WBInteraction000407218
WBInteraction000411359
WBInteraction000412157
WBInteraction000416211
WBInteraction000416898
WBInteraction000418942
WBInteraction000419110
WBInteraction000422380
WBInteraction000423621
WBInteraction000427072
WBInteraction000431396
WBInteraction000432416
WBInteraction000447841
WBInteraction000448705
WBInteraction000448983
WBInteraction000450707
WBInteraction000454561
WBInteraction000454680
WBInteraction000454783
WBInteraction000458675
WBInteraction000460001
WBInteraction000460913
WBInteraction000520797
WBInteraction000549592
WBInteraction000554623
WBInteraction000562138
WBInteraction000567750
WBInteraction000570313
WBInteraction000571082
WBInteraction000571118
WBInteraction000572372
WBInteraction000578110
WBInteraction000583450
Map_infoMapVPosition-4.91265Error0.038419
PositivePositive_cloneF54D11Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00027622
WBPaper00029012
WBPaper00029127
WBPaper00043645
WBPaper00044448
WBPaper00048598
WBPaper00050085
WBPaper00060431
WBPaper00062390
WBPaper00064105
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene