WormBase Tree Display for Gene: WBGene00004945
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WBGene00004945 | Evidence | Person_evidence | WBPerson160 | ||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | CHROMOSOME_II | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | sop-2 | Person_evidence | WBPerson160 | |||||
Sequence_name | C50E10.4 | ||||||||
Molecular_name | C50E10.4a | ||||||||
C50E10.4a.1 | |||||||||
CE32334 | |||||||||
C50E10.4b | |||||||||
CE47166 | |||||||||
C50E10.4c | |||||||||
CE47133 | |||||||||
C50E10.4b.1 | |||||||||
C50E10.4c.1 | |||||||||
Other_name | CELE_C50E10.4 | Accession_evidence | NDB | BX284602 | |||||
Public_name | sop-2 | ||||||||
DB_info | Database | AceView | gene | 2M633 | |||||
WormQTL | gene | WBGene00004945 | |||||||
WormFlux | gene | WBGene00004945 | |||||||
NDB | locus_tag | CELE_C50E10.4 | |||||||
NCBI | gene | 174874 | |||||||
RefSeq | protein | NM_001267413.3 | |||||||
NM_001267412.2 | |||||||||
NM_001267411.2 | |||||||||
SwissProt | UniProtAcc | Q965H3 | |||||||
TrEMBL | UniProtAcc | H8P172 | |||||||
H8P173 | |||||||||
UniProt_GCRP | UniProtAcc | Q965H3 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:37 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | sop | ||||||||
Allele (141) | |||||||||
Strain | WBStrain00036186 | ||||||||
WBStrain00007188 | |||||||||
WBStrain00008579 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (32) | |||||||||
Ortholog | WBGene00070774 | Caenorhabditis remanei | From_analysis | OMA | |||||
WBGene00060128 | Caenorhabditis remanei | From_analysis | Inparanoid_8 | ||||||
Sp34_20051800 | Caenorhabditis inopinata | From_analysis | WormBase-Compara | ||||||
chrII_pilon.g6141 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
WBGene00125506 | Caenorhabditis japonica | From_analysis | WormBase-Compara | ||||||
Paralog | WBGene00010552 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | sop-2 encodes a SAM domain-containing protein that is related to, but not orthologous with, Polycomb group proteins and ETS transcription factors; during development, SOP-2 activity is required for the proper integration of sexual, spatial, and temporal information during cell fate specification; specifically, SOP-2 is required for maintaining a restricted pattern of Hox gene expression, such as that of mab-5 and egl-5, to specific cells and tissues such as the serotonergic and dopaminergic male tail neurons and the ventral nerve cord; in addition, SOP-2 is required for the proper sexual and temporal specification of the hypodermal seam cells; in regulating temporal fate specification, genetic analyses indicate that sop-2 acts upstream of lin-29 in the heterochronic pathway and interacts with other members of the heterochronic pathway, such as lin-4, let-7, and hbl-1, to integrate temporal information and cell fate specification; sop-2 mutations also result in an increase in ALG-1-containing P bodies in hypodermal seam cells; in regulating neurotransmitter phenotype, sop-2 functions together with sor-3, which also encodes a Polycomb group protein, and members of the TGF-beta signaling pathway; sop-2 and sor-3 also function together to regulate progression through larval development; a SOP-2::GFP reporter fusion is expressed in the nuclei of all somatic cells beginning at the 50-cell stage of embryogenesis; SOP-2::GFP expression is initially diffuse, but by the 200-cell stage is visible in distinct nuclear bodies, the size and number of which may correlate with DNA content. | Paper_evidence | WBPaper00005924 | |||||
WBPaper00024202 | |||||||||
WBPaper00028988 | |||||||||
WBPaper00031488 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 08 Aug 2008 00:00:00 | ||||||||
Automated_description | Enables RNA binding activity; protein homodimerization activity; and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of cytoplasmic mRNA processing body assembly; neuron differentiation; and regulation of gene expression. Located in nuclear speck. Expressed widely. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Molecular_info | Corresponding_CDS | C50E10.4a | |||||||
C50E10.4b | |||||||||
C50E10.4c | |||||||||
Corresponding_CDS_history | C50E10.4:wp89 | ||||||||
Corresponding_transcript | C50E10.4a.1 | ||||||||
C50E10.4b.1 | |||||||||
C50E10.4c.1 | |||||||||
Associated_feature (9) | |||||||||
Transcription_factor | WBTranscriptionFactor000203 | ||||||||
Experimental_info | RNAi_result (21) | ||||||||
Expr_pattern | Expr2597 | ||||||||
Expr12241 | |||||||||
Expr1025868 | |||||||||
Expr1032460 | |||||||||
Expr1146873 | |||||||||
Expr2016005 | |||||||||
Expr2034240 | |||||||||
Drives_construct | WBCnstr00000173 | ||||||||
WBCnstr00000174 | |||||||||
WBCnstr00035311 | |||||||||
Construct_product | WBCnstr00035311 | ||||||||
Microarray_results (29) | |||||||||
Expression_cluster (128) | |||||||||
Interaction | WBInteraction000002252 | ||||||||
WBInteraction000002944 | |||||||||
WBInteraction000004071 | |||||||||
WBInteraction000004072 | |||||||||
WBInteraction000004073 | |||||||||
WBInteraction000007064 | |||||||||
WBInteraction000007105 | |||||||||
WBInteraction000007625 | |||||||||
WBInteraction000008621 | |||||||||
WBInteraction000028863 | |||||||||
WBInteraction000030076 | |||||||||
WBInteraction000031154 | |||||||||
WBInteraction000031466 | |||||||||
WBInteraction000052821 | |||||||||
WBInteraction000144286 | |||||||||
WBInteraction000165730 | |||||||||
WBInteraction000166041 | |||||||||
WBInteraction000166164 | |||||||||
WBInteraction000166276 | |||||||||
WBInteraction000501116 | |||||||||
WBInteraction000501117 | |||||||||
WBInteraction000501331 | |||||||||
WBInteraction000501334 | |||||||||
WBInteraction000501335 | |||||||||
WBInteraction000501899 | |||||||||
WBInteraction000501900 | |||||||||
WBInteraction000501901 | |||||||||
WBInteraction000501902 | |||||||||
WBInteraction000502772 | |||||||||
WBInteraction000502775 | |||||||||
WBInteraction000502777 | |||||||||
WBInteraction000502779 | |||||||||
WBInteraction000503481 | |||||||||
WBInteraction000515540 | |||||||||
WBInteraction000517618 | |||||||||
WBInteraction000517619 | |||||||||
WBInteraction000517691 | |||||||||
WBInteraction000517903 | |||||||||
WBInteraction000517904 | |||||||||
WBInteraction000522779 | |||||||||
WBInteraction000522780 | |||||||||
WBInteraction000522781 | |||||||||
WBInteraction000522782 | |||||||||
WBInteraction000522783 | |||||||||
WBInteraction000539371 | |||||||||
WBInteraction000542883 | |||||||||
WBInteraction000546913 | |||||||||
WBInteraction000547545 | |||||||||
WBInteraction000547546 | |||||||||
WBInteraction000547547 | |||||||||
WBInteraction000555790 | |||||||||
WBInteraction000565325 | |||||||||
WBInteraction000517740 | |||||||||
WBInteraction000517741 | |||||||||
WBInteraction000517742 | |||||||||
Map_info | Map | II | Position | 8.55189 | Error | 0.18042 | |||
Positive | Positive_clone | C50E10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 4624 | |||||||
4686 | |||||||||
Pseudo_map_position | |||||||||
Reference (28) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |