WormBase Tree Display for Gene: WBGene00004189

WBGene00004189 SMap: S_parent: Sequence: T20H4
  Identity: Version: 2
    Name (5)
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:34 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 29 Jan 2010 14:16:16 WBPerson2970 Name_change: CGC_name: pars-1
                Other_name: prs-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: pars
    Allele (15)
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (36)
    Paralog: WBGene00000659 Caenorhabditis elegans From_analysis: TreeFam
      WBGene00001337 Caenorhabditis elegans From_analysis: Panther
      WBGene00004190 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00006617 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00044344 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: prs-1 encodes a predicted cytoplasmic prolyl-tRNA synthetase (ProRS), a class II aminoacyl-tRNA synthetase that catalyzes the attachment of proline to its cognate tRNA and is thus required for protein biosynthesis; PRS-1 is required for embryonic, germline, and postembryonic development. Paper_evidence: WBPaper00004403
            WBPaper00004651
            WBPaper00005654
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable proline-tRNA ligase activity. Predicted to be involved in prolyl-tRNA aminoacylation. Predicted to be located in cytoplasm. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 15. Is an ortholog of human EPRS1 (glutamyl-prolyl-tRNA synthetase 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070398 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3418)
  Molecular_info: Corresponding_CDS: T20H4.3a
      T20H4.3b
    Corresponding_CDS_history: T20H4.3:wp130
    Corresponding_transcript: T20H4.3a.1
      T20H4.3b.1
    Other_sequence (103)
    Associated_feature (12)
  Experimental_info: RNAi_result (17)
    Expr_pattern: Expr1028773
      Expr1032049
      Expr1157227
      Expr2014738
      Expr2032972
    Drives_construct: WBCnstr00037929
    Construct_product: WBCnstr00037929
    Microarray_results (24)
    Expression_cluster (112)
    Interaction: WBInteraction000007273
      WBInteraction000029812
      WBInteraction000038879
      WBInteraction000038880
      WBInteraction000040703
      WBInteraction000041549
      WBInteraction000107005
      WBInteraction000110573
      WBInteraction000110878
      WBInteraction000111066
      WBInteraction000138381
      WBInteraction000144947
      WBInteraction000146153
      WBInteraction000151022
      WBInteraction000157079
      WBInteraction000160735
      WBInteraction000160941
      WBInteraction000162843
      WBInteraction000168650
      WBInteraction000171269
      WBInteraction000174558
      WBInteraction000175909
      WBInteraction000181476
      WBInteraction000181477
      WBInteraction000182564
      WBInteraction000183730
      WBInteraction000183827
      WBInteraction000185414
      WBInteraction000185763
      WBInteraction000187065
      WBInteraction000187683
      WBInteraction000189653
      WBInteraction000194500
      WBInteraction000200462
      WBInteraction000202433
      WBInteraction000205118
      WBInteraction000207170
      WBInteraction000208087
      WBInteraction000210053
      WBInteraction000212559
      WBInteraction000213724
      WBInteraction000218799
      WBInteraction000224537
      WBInteraction000229065
      WBInteraction000231497
      WBInteraction000237644
      WBInteraction000240110
      WBInteraction000243378
      WBInteraction000243408
      WBInteraction000243429
      WBInteraction000243440
      WBInteraction000243570
      WBInteraction000243571
      WBInteraction000243572
      WBInteraction000243596
      WBInteraction000243803
      WBInteraction000243871
      WBInteraction000243905
      WBInteraction000243929
      WBInteraction000244015
      WBInteraction000244062
      WBInteraction000244747
      WBInteraction000244945
      WBInteraction000249164
      WBInteraction000249722
      WBInteraction000250423
      WBInteraction000250520
      WBInteraction000250859
      WBInteraction000251738
      WBInteraction000256787
      WBInteraction000257509
      WBInteraction000257999
      WBInteraction000261782
      WBInteraction000265467
      WBInteraction000267978
      WBInteraction000269430
      WBInteraction000271495
      WBInteraction000272376
      WBInteraction000274117
      WBInteraction000276506
      WBInteraction000277626
      WBInteraction000278138
      WBInteraction000280720
      WBInteraction000286764
      WBInteraction000286940
      WBInteraction000288639
      WBInteraction000288672
      WBInteraction000288904
      WBInteraction000289642
      WBInteraction000296066
      WBInteraction000297401
      WBInteraction000298276
      WBInteraction000300004
      WBInteraction000302755
      WBInteraction000304514
      WBInteraction000306367
      WBInteraction000310977
      WBInteraction000312708
      WBInteraction000315328
      WBInteraction000320622
      WBInteraction000326112
      WBInteraction000332126
      WBInteraction000333099
      WBInteraction000334754
      WBInteraction000337029
      WBInteraction000340240
      WBInteraction000340319
      WBInteraction000340809
      WBInteraction000341605
      WBInteraction000348256
      WBInteraction000349068
      WBInteraction000355515
      WBInteraction000358931
      WBInteraction000359159
      WBInteraction000360867
      WBInteraction000364725
      WBInteraction000365719
      WBInteraction000366278
      WBInteraction000366764
      WBInteraction000368089
      WBInteraction000369817
      WBInteraction000369855
      WBInteraction000369915
      WBInteraction000370405
      WBInteraction000372381
      WBInteraction000373041
      WBInteraction000373338
      WBInteraction000375530
      WBInteraction000377362
      WBInteraction000378635
      WBInteraction000379298
      WBInteraction000380619
      WBInteraction000383798
      WBInteraction000385176
      WBInteraction000386520
      WBInteraction000390593
      WBInteraction000390823
      WBInteraction000392064
      WBInteraction000393305
      WBInteraction000394414
      WBInteraction000396791
      WBInteraction000397076
      WBInteraction000398932
      WBInteraction000400452
      WBInteraction000402454
      WBInteraction000404371
      WBInteraction000404926
      WBInteraction000409919
      WBInteraction000410200
      WBInteraction000412359
      WBInteraction000412687
      WBInteraction000412764
      WBInteraction000412953
      WBInteraction000413839
      WBInteraction000414101
      WBInteraction000417972
      WBInteraction000419901
      WBInteraction000421421
      WBInteraction000422088
      WBInteraction000423529
      WBInteraction000423975
      WBInteraction000424155
      WBInteraction000424432
      WBInteraction000424518
      WBInteraction000425706
      WBInteraction000427081
      WBInteraction000428428
      WBInteraction000431349
      WBInteraction000432090
      WBInteraction000434391
      WBInteraction000436046
      WBInteraction000436956
      WBInteraction000437642
      WBInteraction000439008
      WBInteraction000439501
      WBInteraction000440162
      WBInteraction000440299
      WBInteraction000445338
      WBInteraction000445501
      WBInteraction000445840
      WBInteraction000446206
      WBInteraction000447510
      WBInteraction000449529
      WBInteraction000450279
      WBInteraction000452000
      WBInteraction000456142
      WBInteraction000456629
      WBInteraction000458547
      WBInteraction000461455
      WBInteraction000462042
      WBInteraction000462955
      WBInteraction000463363
      WBInteraction000463729
      WBInteraction000463970
      WBInteraction000464259
      WBInteraction000464336
      WBInteraction000464359
      WBInteraction000464473
      WBInteraction000464732
      WBInteraction000464980
      WBInteraction000465079
      WBInteraction000465180
      WBInteraction000465225
      WBInteraction000465260
      WBInteraction000465381
      WBInteraction000465468
      WBInteraction000465550
      WBInteraction000465721
      WBInteraction000465960
      WBInteraction000466091
      WBInteraction000466268
      WBInteraction000466402
      WBInteraction000466478
      WBInteraction000466549
      WBInteraction000466619
      WBInteraction000466739
      WBInteraction000466962
      WBInteraction000467426
      WBInteraction000467765
      WBInteraction000467766
      WBInteraction000467767
      WBInteraction000467768
      WBInteraction000467779
      WBInteraction000468017
      WBInteraction000468730
      WBInteraction000468744
      WBInteraction000468842
      WBInteraction000469347
      WBInteraction000469494
      WBInteraction000469579
      WBInteraction000470078
      WBInteraction000470735
      WBInteraction000470817
      WBInteraction000470898
      WBInteraction000470970
      WBInteraction000470973
      WBInteraction000471560
      WBInteraction000471981
      WBInteraction000472033
      WBInteraction000472076
      WBInteraction000472110
      WBInteraction000472621
      WBInteraction000472722
      WBInteraction000473094
      WBInteraction000473138
      WBInteraction000473371
      WBInteraction000473422
      WBInteraction000473562
      WBInteraction000473912
      WBInteraction000474742
      WBInteraction000475213
      WBInteraction000475347
      WBInteraction000539027
      WBInteraction000544314
      WBInteraction000550553
      WBInteraction000550554
      WBInteraction000550555
      WBInteraction000550651
      WBInteraction000550653
      WBInteraction000550654
      WBInteraction000550655
      WBInteraction000553902
      WBInteraction000554283
      WBInteraction000559483
      WBInteraction000563268
      WBInteraction000564118
      WBInteraction000564818
      WBInteraction000566238
      WBInteraction000566517
      WBInteraction000567371
      WBInteraction000568734
      WBInteraction000572226
      WBInteraction000574101
      WBInteraction000577240
      WBInteraction000578317
      WBInteraction000580269
      WBInteraction000584557
  Map_info: Map: III Position: -0.766312 Error: 0.000666
    Positive: Positive_clone: T20H4 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00035228
    WBPaper00038491
    WBPaper00055090
    WBPaper00057218
  Remark: Connection made from predicted gene which has synthetase Pfam domain similarity. [sdm 12/01]
    dl1 : porbably cytoplasmic
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene