WormBase Tree Display for Gene: WBGene00003058
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| WBGene00003058 | SMap | S_parent | Sequence | CHROMOSOME_II | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | lov-1 | Person_evidence | WBPerson625 | |||||
| Sequence_name | ZK945.9 | ||||||||
| Molecular_name | ZK945.9 | ||||||||
| ZK945.9.1 | |||||||||
| CE45696 | |||||||||
| Other_name | pkd-1 | ||||||||
| CELE_ZK945.9 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | lov-1 | ||||||||
| DB_info | Database | AceView | gene | 2K400 | |||||
| WormQTL | gene | WBGene00003058 | |||||||
| WormFlux | gene | WBGene00003058 | |||||||
| OMIM | disease | 173900 | |||||||
| 601313 | |||||||||
| NDB | locus_tag | CELE_ZK945.9 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003058|UniProtKB=Q09624 | |||||||
| family | PTHR10877 | ||||||||
| NCBI | gene | 174576 | |||||||
| RefSeq | protein | NM_063783.4 | |||||||
| SwissProt | UniProtAcc | Q09624 | |||||||
| UniProt_GCRP | UniProtAcc | Q09624 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lov | ||||||||
| Allele (183) | |||||||||
| Strain | WBStrain00030878 | ||||||||
| WBStrain00030885 | |||||||||
| WBStrain00030886 | |||||||||
| WBStrain00031467 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (34) | |||||||||
| Ortholog (27) | |||||||||
| Paralog | WBGene00004035 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00016889 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | lov-1 encodes a transmembrane protein orthologous to human PKD1; lov-1 is required for two aspects of male mating behavior: response to hermaphrodite contact and vulva location and acts with PKD-2, a TRPP cation channel; LOV-1 is expressed in three types of male-specific neurons and localizes to the cell bodies and cilia; EGL-44 and EGL-46 regulate cell-specific expression of lov-1 and pkd-2 to specify the behavioral function of the HOB hook sensillum neuron; in vitro, LOV-1 interacts, via its conserved PLAT domain, with the N-terminus of ATP-2, the beta subunit of ATP synthase that also localizes to cilia, suggesting that ATP synthase may play a role in C. elegans polycystin signaling. | Paper_evidence (4) | ||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 12 Aug 2011 00:00:00 | ||||||||
| Automated_description | Enables protein domain specific binding activity. Involved in response to hermaphrodite contact and vulval location. Located in neuronal cell body and non-motile cilium. Expressed in CEM and in male. Used to study autosomal dominant polycystic kidney disease. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:898 | Homo sapiens | Paper_evidence (2) | |||||
| Accession_evidence | OMIM | 173900 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 30 Apr 2018 00:00:00 | ||||||||
| Disease_relevance | lov-1 and pkd-2 encode the orthologs of human Polycystin-1 and Polycystin-2, which are mutated in autosomal dominant polycystic kidney disease; the polycystins regulate signaling involved in normal renal tubular structure and function; studies in the worm C. elegans have contributed extensively to the finding that cystic kidney diseases can be considered ciliopathies; in elegans lov-1 and pkd-2 are expressed in male ciliary neurons, are required for normal male mating behavior, do not seem to be required for ciliogenesis, and each polycystin may actually have a potential inhibitory function on the other for ciliary function; lov-1 and pkd-1 interact with a single-pass transmembrane protein, CWP-5, though the significance of this interaction for polycystic kidney disease is unknown. | Homo sapiens | Paper_evidence | WBPaper00003680 | |||||
| Accession_evidence | OMIM | 601313 | |||||||
| 173900 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 31 Jan 2013 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000024 | ||||||||
| WBDOannot00000512 | |||||||||
| WBDOannot00000515 | |||||||||
| WBDOannot00000516 | |||||||||
| Molecular_info | Corresponding_CDS | ZK945.9 | |||||||
| Corresponding_CDS_history | ZK945.9:wp188 | ||||||||
| ZK945.9:wp222 | |||||||||
| Corresponding_transcript | ZK945.9.1 | ||||||||
| Other_sequence | JI173898.1 | ||||||||
| JO470013.1 | |||||||||
| JO468300.1 | |||||||||
| JI164556.1 | |||||||||
| Associated_feature | WBsf989248 | ||||||||
| WBsf1012968 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr1148 | ||||||||
| Expr3208 | |||||||||
| Expr11946 | |||||||||
| Expr1025218 | |||||||||
| Expr1163281 | |||||||||
| Expr2013249 | |||||||||
| Expr2031480 | |||||||||
| Drives_construct | WBCnstr00006717 | ||||||||
| WBCnstr00010107 | |||||||||
| WBCnstr00014864 | |||||||||
| WBCnstr00014875 | |||||||||
| WBCnstr00019759 | |||||||||
| WBCnstr00019881 | |||||||||
| WBCnstr00036257 | |||||||||
| Construct_product | WBCnstr00014869 | ||||||||
| WBCnstr00014875 | |||||||||
| WBCnstr00019759 | |||||||||
| WBCnstr00036257 | |||||||||
| Antibody | WBAntibody00002515 | ||||||||
| WBAntibody00002632 | |||||||||
| Microarray_results (22) | |||||||||
| Expression_cluster (64) | |||||||||
| Interaction | WBInteraction000003348 | ||||||||
| WBInteraction000003360 | |||||||||
| WBInteraction000003817 | |||||||||
| WBInteraction000003823 | |||||||||
| WBInteraction000005645 | |||||||||
| WBInteraction000005649 | |||||||||
| WBInteraction000008609 | |||||||||
| WBInteraction000028390 | |||||||||
| WBInteraction000028392 | |||||||||
| WBInteraction000030456 | |||||||||
| WBInteraction000126261 | |||||||||
| WBInteraction000126831 | |||||||||
| WBInteraction000127072 | |||||||||
| WBInteraction000133226 | |||||||||
| WBInteraction000140927 | |||||||||
| WBInteraction000153186 | |||||||||
| WBInteraction000157131 | |||||||||
| WBInteraction000166031 | |||||||||
| WBInteraction000180404 | |||||||||
| WBInteraction000185235 | |||||||||
| WBInteraction000190788 | |||||||||
| WBInteraction000195345 | |||||||||
| WBInteraction000218512 | |||||||||
| WBInteraction000220958 | |||||||||
| WBInteraction000228829 | |||||||||
| WBInteraction000238525 | |||||||||
| WBInteraction000255128 | |||||||||
| WBInteraction000262302 | |||||||||
| WBInteraction000293215 | |||||||||
| WBInteraction000297762 | |||||||||
| WBInteraction000314986 | |||||||||
| WBInteraction000327373 | |||||||||
| WBInteraction000333718 | |||||||||
| WBInteraction000345324 | |||||||||
| WBInteraction000356685 | |||||||||
| WBInteraction000362229 | |||||||||
| WBInteraction000381746 | |||||||||
| WBInteraction000427343 | |||||||||
| WBInteraction000457252 | |||||||||
| WBInteraction000464218 | |||||||||
| WBInteraction000501599 | |||||||||
| WBInteraction000501600 | |||||||||
| WBInteraction000501686 | |||||||||
| WBInteraction000502594 | |||||||||
| WBInteraction000502943 | |||||||||
| WBInteraction000504327 | |||||||||
| WBInteraction000504824 | |||||||||
| WBInteraction000518568 | |||||||||
| WBInteraction000519222 | |||||||||
| WBInteraction000522718 | |||||||||
| WBInteraction000522720 | |||||||||
| WBInteraction000524005 | |||||||||
| WBInteraction000524020 | |||||||||
| WBInteraction000524378 | |||||||||
| WBInteraction000525376 | |||||||||
| WBInteraction000541502 | |||||||||
| WBInteraction000556424 | |||||||||
| WBInteraction000557011 | |||||||||
| WBProcess | WBbiopr:00000012 | ||||||||
| Map_info | Map | II | Position | 1.90347 | Error | 0.014559 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | ZK945 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 3960 | |||||||
| 3961 | |||||||||
| 5093 | |||||||||
| Pos_neg_data | 10577 | ||||||||
| 10578 | |||||||||
| 10579 | |||||||||
| 10580 | |||||||||
| 10581 | |||||||||
| 10582 | |||||||||
| Reference (101) | |||||||||
| Method | Gene |
