WormBase Tree Display for Gene: WBGene00001650
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| WBGene00001650 | SMap | S_parent | Sequence | CHROMOSOME_IV | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | gon-1 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F25H8.3 | ||||||||
| Molecular_name | F25H8.3a | ||||||||
| F25H8.3a.1 | |||||||||
| CE42668 | |||||||||
| F25H8.3b | |||||||||
| CE46622 | |||||||||
| F25H8.3a.2 | |||||||||
| F25H8.3b.1 | |||||||||
| F25H8.3c | |||||||||
| Other_name | CELE_F25H8.3 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | gon-1 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:25 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gon | ||||||||
| Allele (221) | |||||||||
| Legacy_information | [C.elegansII] e1254 : defective formation of somatic gonad primordium; much germ line proliferation, almost no gamete maturation, variable vulval induction, no uterus. e1254/Df similar.ES3. ME0 (male somatic gonad also abnormal). OA4:e2547, e2551, q517, q518 (similar). [Hodgkin et al. 1989; CB; JK] | ||||||||
| Strain | WBStrain00022578 | ||||||||
| WBStrain00022613 | |||||||||
| WBStrain00004564 | |||||||||
| WBStrain00050795 | |||||||||
| WBStrain00054932 | |||||||||
| WBStrain00054931 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (30) | |||||||||
| Ortholog (56) | |||||||||
| Paralog | WBGene00000082 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00000083 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00086562 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00003242 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00009958 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00020567 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00021171 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003248 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | gon-1 encodes a functional metalloprotease that defines a new sub-family of secreted proteases known as MPT (metalloprotease with thrombospondin type 1 repeats); the other two members of this family are the bovine procollagen I N-protease ( PINP ) and the murine enzyme ADAMTS-1; gon-1 is essential for hermaphrodite gonadal morphogenesis and sequence homology with other metalloproteases suggests that it functions by remodeling the extracellular matrix; gon-1 is also required for protein transport from the endoplasmic reticulum (ER) to the Golgi, a function dependent on its C-terminal GON domain; GON-1 is expressed at high levels within the gonadal distal tip cell during migration and also in body wall muscle cells; in the distal tip cell, reporter fusion constructs expressing the GON domain localize to the endoplasmic reticulum, suggesting that GON-1 functions both intra- and extracellularly. | Paper_evidence | WBPaper00003556 | |||||
| WBPaper00003841 | |||||||||
| WBPaper00040883 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson324 | |||||||||
| Date_last_updated | 16 Mar 2012 00:00:00 | ||||||||
| Automated_description | Enables metallopeptidase activity. Involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; muscle organ morphogenesis; and negative regulation of presynapse assembly. Predicted to be located in extracellular matrix. Expressed in amphid neurons; excretory cell; gonad; motor neurons; and muscle cell. Used to study obesity and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Is an ortholog of human ADAMTS20 (ADAM metallopeptidase with thrombospondin type 1 motif 20) and ADAMTS9 (ADAM metallopeptidase with thrombospondin type 1 motif 9). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:9352 | Homo sapiens | Paper_evidence | WBPaper00048391 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 28 Oct 2015 00:00:00 | ||||||||
| DOID:9970 | Homo sapiens | Paper_evidence | WBPaper00061889 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 28 Jun 2022 00:00:00 | ||||||||
| Potential_model | DOID:7148 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:220) | |||||
| Models_disease_in_annotation | WBDOannot00000381 | ||||||||
| WBDOannot00001255 | |||||||||
| Molecular_info | Corresponding_CDS | F25H8.3a | |||||||
| F25H8.3b | |||||||||
| Corresponding_CDS_history | F25H8.3:wp191 | ||||||||
| Corresponding_transcript | F25H8.3c | ||||||||
| F25H8.3a.1 | |||||||||
| F25H8.3a.2 | |||||||||
| F25H8.3b.1 | |||||||||
| Other_sequence | JI164015.1 | ||||||||
| Dviv_isotig32909 | |||||||||
| MP00069 | |||||||||
| CBC09661_1 | |||||||||
| Dviv_isotig16135 | |||||||||
| Oden_isotig19638 | |||||||||
| Hbac_isotig07485 | |||||||||
| Associated_feature (17) | |||||||||
| Experimental_info | RNAi_result (23) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00003119 | ||||||||
| WBCnstr00010223 | |||||||||
| WBCnstr00021147 | |||||||||
| WBCnstr00021148 | |||||||||
| WBCnstr00036796 | |||||||||
| Construct_product | WBCnstr00016199 | ||||||||
| WBCnstr00020015 | |||||||||
| WBCnstr00036796 | |||||||||
| Microarray_results (23) | |||||||||
| Expression_cluster (151) | |||||||||
| Interaction | WBInteraction000000845 | ||||||||
| WBInteraction000004893 | |||||||||
| WBInteraction000004894 | |||||||||
| WBInteraction000004895 | |||||||||
| WBInteraction000008676 | |||||||||
| WBInteraction000029166 | |||||||||
| WBInteraction000037631 | |||||||||
| WBInteraction000038546 | |||||||||
| WBInteraction000049427 | |||||||||
| WBInteraction000052739 | |||||||||
| WBInteraction000052740 | |||||||||
| WBInteraction000052918 | |||||||||
| WBInteraction000161314 | |||||||||
| WBInteraction000166254 | |||||||||
| WBInteraction000212965 | |||||||||
| WBInteraction000223559 | |||||||||
| WBInteraction000224886 | |||||||||
| WBInteraction000228738 | |||||||||
| WBInteraction000238818 | |||||||||
| WBInteraction000288707 | |||||||||
| WBInteraction000316621 | |||||||||
| WBInteraction000370666 | |||||||||
| WBInteraction000413120 | |||||||||
| WBInteraction000502946 | |||||||||
| WBInteraction000502947 | |||||||||
| WBInteraction000517784 | |||||||||
| WBInteraction000534755 | |||||||||
| WBInteraction000534757 | |||||||||
| WBInteraction000534758 | |||||||||
| WBInteraction000534759 | |||||||||
| WBInteraction000534760 | |||||||||
| WBInteraction000541736 | |||||||||
| WBInteraction000555967 | |||||||||
| WBInteraction000555968 | |||||||||
| WBInteraction000555969 | |||||||||
| WBInteraction000556879 | |||||||||
| Map_info | Map | IV | Position | 4.4533 | Error | 0.0006 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | F25H8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data (2) | |||||||||
| Reference (59) | |||||||||
| Method | Gene |
