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WormBase Tree Display for Gene: WBGene00001401

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Name Class

WBGene00001401SMapS_parentSequenceH12I13
IdentityVersion1
Name (5)
DB_infoDatabaseAceViewgene2G370
WormQTLgeneWBGene00001401
WormFluxgeneWBGene00001401
NDBlocus_tagCELE_H12I13.4
PanthergeneCAEEL|WormBase=WBGene00001401|UniProtKB=Q9N5M6
familyPTHR12537
NCBIgene174016
RefSeqproteinNM_062815.8
SwissProtUniProtAccQ9N5M6
TREEFAMTREEFAM_IDTF318622
UniProt_GCRPUniProtAccQ9N5M6
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:24WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classfbf
Allele (53)
Legacy_information[Gallegos M, Zhang B] fbf-1(RNAi) animals produce excess sperm and no oocytes (Mog phenotype). Encodes fem-3 PME RNA binding protein, 91% identical to FBF-2
StrainWBStrain00022602
WBStrain00022603
WBStrain00022612
WBStrain00022628
WBStrain00022640
WBStrain00022344
WBStrain00022346
WBStrain00022396
WBStrain00022400
RNASeq_FPKM (74)
GO_annotation (27)
Ortholog (33)
ParalogWBGene00004239Caenorhabditis elegansFrom_analysisInparanoid_8
Panther
WormBase-Compara
WBGene00001402Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
Panther
WormBase-Compara
WBGene00022257Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
Panther
WormBase-Compara
WBGene00004241Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
Panther
WormBase-Compara
WBGene00004243Caenorhabditis elegansFrom_analysisInparanoid_8
Panther
WormBase-Compara
WBGene00004242Caenorhabditis elegansFrom_analysisInparanoid_8
Panther
WormBase-Compara
WBGene00004240Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
WBGene00004244Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00004245Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionfbf-1 encodes an RNA-binding protein that is one of 12 C. elegans members of the PUF family (Pumilio and FBF) of translational regulators; FBF-1 is nearly identical to FBF-2 with which it is largely redundant in regulating two aspects of germline development: 1) maintenance of stem cell proliferation, and 2) the hermaphroditic switch between spermatogenesis and oogenesis; FBF-1 also plays a role in regulating adaptation in the AWC chemosensory neuron by binding and enhancing translation of the egl-4 mRNA; in maintaining germline stem cells, the FBF proteins, acting through NOS-3, negatively regulate the activity of gld-1 mRNA, which encodes a translational repressor required for meiotic entry; in regulating the sperm-to-oocyte switch, the FBFs act downstream of GLD-3 to negatively regulate the activity of fem-3 mRNA, which encodes a novel protein required for germline sex determination; consistent with their role in germline development, FBF-1 and FBF-2 are expressed in the germline cytoplasm, becoming enriched in the mitotic region during the L4 larval and adult stages.Paper_evidenceWBPaper00002949
WBPaper00004396
WBPaper00005265
WBPaper00005566
WBPaper00006369
WBPaper00032496
Curator_confirmedWBPerson1843
Date_last_updated17 Feb 2009 00:00:00
Automated_descriptionEnables mRNA 3'-UTR binding activity. Involved in several processes, including germline cell cycle switching, mitotic to meiotic cell cycle; olfactory learning; and regulation of gene expression. Located in germ cell nucleus and perinuclear region of cytoplasm. Expressed in germ line.Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSH12I13.4
Corresponding_transcriptH12I13.4.1
Associated_featureWBsf650110
WBsf1012315
WBsf223128
Gene_product_bindsWBsf027922
WBsf034330
Transcription_factorWBTranscriptionFactor000123
WBTranscriptionFactor000103
Experimental_infoRNAi_result (58)
Expr_pattern (14)
Drives_constructWBCnstr00005287
WBCnstr00036969
Construct_productWBCnstr00000086
WBCnstr00005234
WBCnstr00036969
WBCnstr00040358
WBCnstr00042579
Regulate_expr_clusterWBPaper00035905:FBF-1_Associated
WBPaper00045618:fbf-1_downregulated
WBPaper00045618:fbf-1_upregulated
WBPaper00055804:FBF-1-FBF-2-associated_oogenic-enriched
WBPaper00055804:FBF-1-FBF-2-associated_spermatogenic-enriched
AntibodyWBAntibody00000156
WBAntibody00000784
WBAntibody00000964
WBAntibody00001086
WBAntibody00002142
WBAntibody00002385
Microarray_results (20)
Expression_cluster (131)
InteractionWBInteraction000003560
WBInteraction000004891
WBInteraction000004892
WBInteraction000005662
WBInteraction000005663
WBInteraction000008774
WBInteraction000008785
WBInteraction000009140
WBInteraction000009151
WBInteraction000009154
WBInteraction000028484
WBInteraction000028827
WBInteraction000050644
WBInteraction000050646
WBInteraction000051749
WBInteraction000052871
WBInteraction000165798
WBInteraction000501419
WBInteraction000501634
WBInteraction000501782
WBInteraction000502002
WBInteraction000502005
WBInteraction000502007
WBInteraction000502263
WBInteraction000503426
WBInteraction000503427
WBInteraction000503912
WBInteraction000505048
WBInteraction000517844
WBInteraction000517845
WBInteraction000517846
WBInteraction000517847
WBInteraction000517848
WBInteraction000517849
WBInteraction000517850
WBInteraction000517851
WBInteraction000517852
WBInteraction000517853
WBInteraction000517854
WBInteraction000517855
WBInteraction000517856
WBInteraction000517857
WBInteraction000517858
WBInteraction000517859
WBInteraction000518829
WBInteraction000519012
WBInteraction000519013
WBInteraction000519015
WBInteraction000519016
WBInteraction000519017
WBInteraction000519018
WBInteraction000520223
WBInteraction000520224
WBInteraction000522446
WBInteraction000534764
WBInteraction000534765
WBInteraction000534766
WBInteraction000538787
WBInteraction000538837
WBInteraction000538838
WBInteraction000540012
WBInteraction000540171
WBInteraction000540572
WBInteraction000540659
WBInteraction000540660
WBInteraction000541205
WBInteraction000541383
WBInteraction000541645
WBInteraction000541677
WBInteraction000541679
WBInteraction000541787
WBInteraction000541788
WBInteraction000541789
WBInteraction000541790
WBInteraction000550518
WBInteraction000550527
WBInteraction000550531
WBInteraction000555198
WBInteraction000555957
WBInteraction000556254
WBInteraction000556267
WBInteraction000556387
WBInteraction000556501
WBInteraction000556503
WBInteraction000556834
WBInteraction000563372
WBInteraction000565589
WBInteraction000569550
WBInteraction000575808
Map_infoMapIIPosition-0.571982Error0.010563
PositivePositive_clone (2)
Mapping_dataMulti_point4304
4305
5274
Pseudo_map_position
Reference (142)
PictureWBPicture0000013095
RemarkData extracted from Zhang et al. (1997)
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene