WormBase Tree Display for Gene: WBGene00001337

WBGene00001337 SMap: S_parent: Sequence: ZC434
  Identity: Version: 2
    Name: CGC_name: ears-1 Person_evidence: WBPerson36
            WBPerson10953
      Sequence_name: ZC434.5
      Molecular_name: ZC434.5
        ZC434.5.1
        CE06580
        ZC434.5.2
      Other_name: qrs-3 CGC_data_submission
        ers-2
        CELE_ZC434.5 Accession_evidence: NDB BX284601
      Public_name: ears-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:24 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 29 Jan 2010 14:16:16 WBPerson2970 Name_change: CGC_name: ears-1
                Other_name: ers-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ears
    Allele (55)
    RNASeq_FPKM (74)
    GO_annotation (21)
    Contained_in_operon: CEOP1596
    Ortholog (39)
    Paralog: WBGene00004189 Caenorhabditis elegans From_analysis: Panther
      WBGene00001336 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00001338 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: ers-2 encodes a predicted mitochondrial glutamyl-tRNA synthetase (GluRS), a class I aminoacyl-tRNA synthetase that catalyzes the attachment of glutamate to its cognate tRNA and is thus required for protein biosynthesis; ERS-2 contains, at its C-terminus, six tandemly repeated WHEP-TRS domains that have been predicted to function as general RNA-binding domains that may act as cis tRNA-binding cofactors. Paper_evidence: WBPaper00004191
            WBPaper00004424
            WBPaper00012791
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable glutamate-tRNA ligase activity. Predicted to be involved in glutamyl-tRNA aminoacylation. Predicted to be located in cytosol. Predicted to be part of methionyl glutamyl tRNA synthetase complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 15. Is an ortholog of human EPRS1 (glutamyl-prolyl-tRNA synthetase 1). Paper_evidence: WBPaper00065943
          Curator_confirmed (2)
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070398 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3418)
  Molecular_info: Corresponding_CDS: ZC434.5
    Corresponding_transcript: ZC434.5.1
      ZC434.5.2
    Other_sequence (82)
    Associated_feature: WBsf656858
      WBsf984977
      WBsf218414
      WBsf218415
  Experimental_info: RNAi_result: WBRNAi00095824 Inferred_automatically: RNAi_primary
      WBRNAi00038058 Inferred_automatically: RNAi_primary
      WBRNAi00096891 Inferred_automatically: RNAi_primary
      WBRNAi00116685 Inferred_automatically: RNAi_primary
      WBRNAi00058913 Inferred_automatically: RNAi_primary
      WBRNAi00096952 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1012731
      Expr1030817
      Expr1162353
      Expr2011150
      Expr2029386
    Drives_construct: WBCnstr00037979
    Construct_product: WBCnstr00016316
      WBCnstr00037979
    Microarray_results (22)
    Expression_cluster (119)
    Interaction: WBInteraction000042254
      WBInteraction000042255
      WBInteraction000042759
      WBInteraction000109089
      WBInteraction000112071
      WBInteraction000115167
      WBInteraction000125327
      WBInteraction000133312
      WBInteraction000133617
      WBInteraction000134589
      WBInteraction000141305
      WBInteraction000141754
      WBInteraction000141774
      WBInteraction000148498
      WBInteraction000149600
      WBInteraction000150372
      WBInteraction000152952
      WBInteraction000159648
      WBInteraction000160835
      WBInteraction000161427
      WBInteraction000163260
      WBInteraction000167990
      WBInteraction000168683
      WBInteraction000170503
      WBInteraction000175265
      WBInteraction000178095
      WBInteraction000178827
      WBInteraction000179321
      WBInteraction000179702
      WBInteraction000183186
      WBInteraction000184102
      WBInteraction000186306
      WBInteraction000186924
      WBInteraction000189351
      WBInteraction000192672
      WBInteraction000193089
      WBInteraction000193763
      WBInteraction000194225
      WBInteraction000200505
      WBInteraction000200993
      WBInteraction000201177
      WBInteraction000202051
      WBInteraction000204437
      WBInteraction000204848
      WBInteraction000205693
      WBInteraction000207998
      WBInteraction000210910
      WBInteraction000211171
      WBInteraction000216721
      WBInteraction000221707
      WBInteraction000228705
      WBInteraction000234730
      WBInteraction000241400
      WBInteraction000246395
      WBInteraction000247439
      WBInteraction000251020
      WBInteraction000253273
      WBInteraction000257240
      WBInteraction000257352
      WBInteraction000261450
      WBInteraction000263926
      WBInteraction000264176
      WBInteraction000264456
      WBInteraction000266046
      WBInteraction000266107
      WBInteraction000266941
      WBInteraction000269016
      WBInteraction000269430
      WBInteraction000270211
      WBInteraction000271211
      WBInteraction000271494
      WBInteraction000271748
      WBInteraction000272612
      WBInteraction000275736
      WBInteraction000277979
      WBInteraction000278382
      WBInteraction000278463
      WBInteraction000278476
      WBInteraction000279520
      WBInteraction000279642
      WBInteraction000280033
      WBInteraction000280146
      WBInteraction000285127
      WBInteraction000287233
      WBInteraction000287661
      WBInteraction000289410
      WBInteraction000298428
      WBInteraction000298784
      WBInteraction000299844
      WBInteraction000300752
      WBInteraction000308553
      WBInteraction000309972
      WBInteraction000310352
      WBInteraction000312059
      WBInteraction000313890
      WBInteraction000315379
      WBInteraction000316860
      WBInteraction000317224
      WBInteraction000318931
      WBInteraction000322589
      WBInteraction000322833
      WBInteraction000323199
      WBInteraction000323951
      WBInteraction000324633
      WBInteraction000324920
      WBInteraction000325220
      WBInteraction000328623
      WBInteraction000328825
      WBInteraction000330279
      WBInteraction000330565
      WBInteraction000331895
      WBInteraction000334286
      WBInteraction000337522
      WBInteraction000338146
      WBInteraction000345959
      WBInteraction000350208
      WBInteraction000352858
      WBInteraction000354319
      WBInteraction000361006
      WBInteraction000361512
      WBInteraction000364254
      WBInteraction000364255
      WBInteraction000365035
      WBInteraction000367345
      WBInteraction000369660
      WBInteraction000376064
      WBInteraction000376406
      WBInteraction000379868
      WBInteraction000382776
      WBInteraction000390410
      WBInteraction000397391
      WBInteraction000402204
      WBInteraction000402747
      WBInteraction000410055
      WBInteraction000413256
      WBInteraction000419307
      WBInteraction000420913
      WBInteraction000423133
      WBInteraction000425839
      WBInteraction000428717
      WBInteraction000429744
      WBInteraction000430081
      WBInteraction000431994
      WBInteraction000432052
      WBInteraction000432301
      WBInteraction000433381
      WBInteraction000433975
      WBInteraction000434418
      WBInteraction000435512
      WBInteraction000438509
      WBInteraction000440044
      WBInteraction000442941
      WBInteraction000444623
      WBInteraction000445212
      WBInteraction000447897
      WBInteraction000447902
      WBInteraction000448429
      WBInteraction000456070
      WBInteraction000456718
      WBInteraction000458530
      WBInteraction000459014
      WBInteraction000462790
      WBInteraction000464440
      WBInteraction000466526
      WBInteraction000468606
      WBInteraction000469324
      WBInteraction000470304
      WBInteraction000470338
      WBInteraction000473492
      WBInteraction000474067
      WBInteraction000474266
      WBInteraction000474981
      WBInteraction000552187
      WBInteraction000553356
      WBInteraction000554545
      WBInteraction000554994
      WBInteraction000555443
      WBInteraction000561344
      WBInteraction000562260
      WBInteraction000564791
      WBInteraction000569050
      WBInteraction000571467
      WBInteraction000572197
      WBInteraction000573416
      WBInteraction000579340
      WBInteraction000585383
      WBInteraction000586701
  Map_info: Map: I Position: 4.90606 Error: 0.010265
    Positive: Positive_clone: ZC434 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00055090
  Remark: dl1 : probably mitochondrial
    ers-2 was an other name of qrs-3 but has been update as ers-2(main name), qrs-3(other-name). ers genes have similarity to both glutamyl tRNA synthetases (ers-) and glutaminyl tRNA synthetases (qrs-). The ers gene class description is thus updated to glutamyl(E)/glutaminyl(Q) aa-tRNA Synthetase
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene