WormBase Tree Display for Gene: WBGene00000939

WBGene00000939 Evidence: Paper_evidence: WBPaper00004772
  SMap: S_parent: Sequence: K12H4
  Identity: Version: 1
    Name: CGC_name: dcr-1 Person_evidence: WBPerson419
      Sequence_name: K12H4.8
      Molecular_name: K12H4.8
        K12H4.8.1
        CE47418
      Other_name (3)
      Public_name: dcr-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:22 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: dcr
    Allele (78)
    Legacy_information: Homozygous s2624 and s2795 each develope into sterile adults.
    Strain (13)
    RNASeq_FPKM (74)
    GO_annotation (61)
    Ortholog (58)
    Paralog: WBGene00001090 Caenorhabditis elegans From_analysis: TreeFam
      WBGene00008400 Caenorhabditis elegans From_analysis: TreeFam
    Structured_description: Concise_description: dcr-1 encodes a bidentate ribonuclease that is homologous to E. coli RNAse III; DCR-1 is required both for RNA interference and for synthesis of small developmental RNAs; DCR-1 functions to process pre-miRNAs into their mature, 22-nt form; DCR-1 interacts in vivo with RDE-4, a double-stranded RNA (dsRNA) binding protein required for RNAi that interacts with trigger dsRNAs and may function to deliver dsRNAs to DCR-1 for endonucleolytic processing; DCR-1 is also required for fragmention of chromosomal DNA during apoptosis, and undergoes a CED-3 protease-mediated conversion from a ribonuclease to a deoxyribonuclease. Paper_evidence: WBPaper00004424
            WBPaper00004923
            WBPaper00005368
            WBPaper00036025
            WBPaper00024573
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 03 Feb 2014 00:00:00
      Automated_description: Enables deoxyribonuclease I activity and ribonuclease III activity. Involved in several processes, including nucleic acid metabolic process; olfactory learning; and positive regulation of primary miRNA processing. Acts upstream of or within defense response to Gram-positive bacterium. Located in cytosol and nucleus. Expressed in germ line; intestine; neurons; and somatic cell. Human ortholog(s) of this gene implicated in several diseases, including DICER1 syndrome; gastrointestinal system cancer (multiple); and multinodular goiter. Is an ortholog of human DICER1 (dicer 1, ribonuclease III). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17098)
      DOID:4769 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17098)
      DOID:0050745 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17098)
      DOID:0080615 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17098)
      DOID:0050489 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17098)
      DOID:10534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17098)
      DOID:0081063 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17098)
      DOID:684 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:17098)
  Molecular_info: Corresponding_CDS: K12H4.8
    Corresponding_CDS_history: K12H4.8:wp230
    Corresponding_transcript: K12H4.8.1
    Other_sequence (58)
    Associated_feature: WBsf651241
      WBsf667129
      WBsf227077
      WBsf227078
  Experimental_info: RNAi_result (65)
    Expr_pattern: Expr10581
      Expr11565
      Expr12215
      Expr12472
      Expr1022725
      Expr1030586
      Expr1154395
      Expr2010807
      Expr2029044
    Drives_construct: WBCnstr00005999
      WBCnstr00006000
      WBCnstr00006001
      WBCnstr00017007
      WBCnstr00020414
      WBCnstr00037186
    Construct_product (13)
    Regulate_expr_cluster: WBPaper00027057:DCR-1_interacting_adult
      WBPaper00027057:DCR-1_interacting_embryo
      WBPaper00029437:dcr-1_downregulated
      WBPaper00029437:dcr-1_upregulated
      WBPaper00059490:dcr-1(m9375)_downregulated
      WBPaper00059490:dcr-1(m9375)_upregulated
    Antibody: WBAntibody00000418
      WBAntibody00001054
      WBAntibody00001326
      WBAntibody00001327
      WBAntibody00001490
      WBAntibody00002257
      WBAntibody00002600
    Microarray_results (18)
    Expression_cluster (137)
    Interaction: WBInteraction000001391
      WBInteraction000001392
      WBInteraction000001393
      WBInteraction000001407
      WBInteraction000001408
      WBInteraction000001446
      WBInteraction000001447
      WBInteraction000001577
      WBInteraction000001578
      WBInteraction000003427
      WBInteraction000003428
      WBInteraction000003429
      WBInteraction000003431
      WBInteraction000003432
      WBInteraction000003468
      WBInteraction000003523
      WBInteraction000003626
      WBInteraction000003627
      WBInteraction000003645
      WBInteraction000004812
      WBInteraction000028855
      WBInteraction000029202
      WBInteraction000029268
      WBInteraction000029764
      WBInteraction000029765
      WBInteraction000040544
      WBInteraction000040545
      WBInteraction000040546
      WBInteraction000040547
      WBInteraction000051440
      WBInteraction000051442
      WBInteraction000051684
      WBInteraction000113428
      WBInteraction000113429
      WBInteraction000113746
      WBInteraction000113747
      WBInteraction000126930
      WBInteraction000161307
      WBInteraction000165500
      WBInteraction000165671
      WBInteraction000166011
      WBInteraction000260931
      WBInteraction000307589
      WBInteraction000314403
      WBInteraction000369257
      WBInteraction000399193
      WBInteraction000401768
      WBInteraction000446468
      WBInteraction000456999
      WBInteraction000500973
      WBInteraction000501095
      WBInteraction000501096
      WBInteraction000501097
      WBInteraction000502560
      WBInteraction000504425
      WBInteraction000504426
      WBInteraction000504427
      WBInteraction000517597
      WBInteraction000517598
      WBInteraction000517676
      WBInteraction000519833
      WBInteraction000520387
      WBInteraction000520388
      WBInteraction000520489
      WBInteraction000520765
      WBInteraction000520846
      WBInteraction000521853
      WBInteraction000521854
      WBInteraction000521855
      WBInteraction000523857
      WBInteraction000539116
      WBInteraction000540054
      WBInteraction000540071
      WBInteraction000540072
      WBInteraction000540073
      WBInteraction000540074
      WBInteraction000540673
      WBInteraction000540683
      WBInteraction000540999
      WBInteraction000541127
      WBInteraction000541260
      WBInteraction000542483
      WBInteraction000543265
      WBInteraction000543269
      WBInteraction000543270
      WBInteraction000543271
      WBInteraction000543272
      WBInteraction000543273
      WBInteraction000543274
      WBInteraction000543275
      WBInteraction000543276
      WBInteraction000543277
      WBInteraction000543278
      WBInteraction000543279
      WBInteraction000543288
      WBInteraction000543294
      WBInteraction000543304
      WBInteraction000543333
      WBInteraction000543334
      WBInteraction000543335
      WBInteraction000543336
      WBInteraction000543337
      WBInteraction000543338
      WBInteraction000543339
      WBInteraction000543340
      WBInteraction000543341
      WBInteraction000543342
      WBInteraction000543343
      WBInteraction000543344
      WBInteraction000543345
      WBInteraction000543346
      WBInteraction000543347
      WBInteraction000543348
      WBInteraction000543349
      WBInteraction000543350
      WBInteraction000543351
      WBInteraction000543352
      WBInteraction000543353
      WBInteraction000543354
      WBInteraction000543355
      WBInteraction000543356
      WBInteraction000543357
      WBInteraction000543358
      WBInteraction000543359
      WBInteraction000543360
      WBInteraction000543361
      WBInteraction000543362
      WBInteraction000543363
      WBInteraction000543364
      WBInteraction000543365
      WBInteraction000543366
      WBInteraction000543367
      WBInteraction000543368
      WBInteraction000543369
      WBInteraction000543370
      WBInteraction000543371
      WBInteraction000543372
      WBInteraction000543373
      WBInteraction000543374
      WBInteraction000543375
      WBInteraction000543376
      WBInteraction000543377
      WBInteraction000543378
      WBInteraction000543379
      WBInteraction000543380
      WBInteraction000543381
      WBInteraction000543382
      WBInteraction000543383
      WBInteraction000543384
      WBInteraction000543385
      WBInteraction000543386
      WBInteraction000543387
      WBInteraction000543388
      WBInteraction000543389
      WBInteraction000543390
      WBInteraction000543391
      WBInteraction000543392
      WBInteraction000543393
      WBInteraction000543394
      WBInteraction000543395
      WBInteraction000543396
      WBInteraction000543397
      WBInteraction000543398
      WBInteraction000543399
      WBInteraction000543400
      WBInteraction000543401
      WBInteraction000543402
      WBInteraction000543403
      WBInteraction000543404
      WBInteraction000543405
      WBInteraction000543406
      WBInteraction000543407
      WBInteraction000543408
      WBInteraction000543409
      WBInteraction000543410
      WBInteraction000543411
      WBInteraction000543412
      WBInteraction000543413
      WBInteraction000543414
      WBInteraction000543415
      WBInteraction000543416
      WBInteraction000543417
      WBInteraction000543418
      WBInteraction000543419
      WBInteraction000543420
      WBInteraction000543421
      WBInteraction000543422
      WBInteraction000543423
      WBInteraction000543424
      WBInteraction000543425
      WBInteraction000543426
      WBInteraction000543427
      WBInteraction000543428
      WBInteraction000543429
      WBInteraction000543430
      WBInteraction000549045
      WBInteraction000549432
      WBInteraction000550367
      WBInteraction000551362
      WBInteraction000554998
      WBInteraction000555234
      WBInteraction000556312
      WBInteraction000556313
      WBInteraction000557755
      WBInteraction000558196
      WBInteraction000563758
      WBInteraction000568900
      WBInteraction000571330
      WBInteraction000571337
      WBInteraction000571341
      WBInteraction000571345
      WBInteraction000571350
      WBInteraction000574998
      WBInteraction000575654
      WBInteraction000576283
      WBInteraction000576971
      WBInteraction000582925
      WBInteraction000583595
      WBInteraction000583596
    WBProcess: WBbiopr:00000014
      WBbiopr:00000039
      WBbiopr:00000057
      WBbiopr:00000073
      WBbiopr:00000081
  Map_info: Map: III Position: -0.385999 Error: 0.003601
    Hide_under: WBGene00002843
    Positive: Inside_rearr: nDf20
        sDp3
        sDp8
      Positive_clone: K12H4 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Outside_rearr: sDf128
    Mapping_data: Multi_point: 5311
      Pos_neg_data: 9651
        9674
        9694
        9695
        9715
  Reference (124)
  Remark: The let-740 gene is the same gene as dcr-1 and they therefore have been merged following advice from the CGC. let-740 is now an other name for dcr-1 [krb 030508]
  Method: Gene