WormBase Tree Display for Gene: WBGene00000469

WBGene00000469 SMap: S_parent: Sequence: ZK909
  Identity: Version: 1
    Name: CGC_name: ces-2 Person_evidence: WBPerson268
      Sequence_name: ZK909.4
      Molecular_name: ZK909.4
        ZK909.4.1
        CE15479
      Other_name: CELE_ZK909.4 Accession_evidence: NDB BX284601
      Public_name: ces-2
    DB_info: Database: AceView gene 1P559
        WormQTL gene WBGene00000469
        WormFlux gene WBGene00000469
        NDB locus_tag CELE_ZK909.4
        Panther gene CAEEL|WormBase=WBGene00000469|UniProtKB=Q94126
          family PTHR11988
        NCBI gene 173365
        RefSeq protein NM_061209.6
        SwissProt UniProtAcc Q94126
        TREEFAM TREEFAM_ID TF315869
        UniProt_GCRP UniProtAcc Q94126
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ces
    Allele (73)
    Legacy_information: [C.elegansII] n732 : sisters of NSM (but not I2) fail to undergo programmed cell death.Cloned: encodes protein related to bZIP transcription factors.[Ellis and Horvitz 1991; MT]
      [C.elegansII] n732 : sisters of NSM (but not I2) fail to undergo programmed cell death. Cloned: encodes protein related to bZIP transcription factors. [Ellis and Horvitz 1991; MT]
    Strain: WBStrain00027189
      WBStrain00036792
      WBStrain00036925
      WBStrain00051976
      WBStrain00055552
    RNASeq_FPKM (74)
    GO_annotation (31)
    Ortholog (51)
    Paralog: WBGene00000220 Caenorhabditis elegans From_analysis: TreeFam
      WBGene00017535 Caenorhabditis elegans From_analysis (3)
      WBGene00013100 Caenorhabditis elegans From_analysis: Panther
      WBGene00011130 Caenorhabditis elegans From_analysis (2)
    Structured_description: Concise_description: ces-2 encodes a basic region leucine-zipper (bZIP) transcription factor, most similar in sequence and binding specificity to the PAR (proline- and acid-rich) subfamily of bZIP proteins; ces-2 is required to activate programmed cell death in the sister cells of the serotoninergic neurosecretory motor (NSM) neurons, and is transcriptionally inhibited by activated LET-60(G12V); in regulating programmed cell death in the NSM sister cell, CES-2 functions together with DNJ-11 to negatively regulate transcription of ces-1 which, in turn, negatively regulates transcription of the pro-apoptotic BH3-only gene egl-1; ces-2 also functions together with dnj-11 to regulate asymmetric cell division and mitotic spindle orientation in the NSM lineage, revealing a functional coupling between asymmetric cell division and apoptosis. Paper_evidence: WBPaper00002515
            WBPaper00005376
            WBPaper00031670
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 15 Dec 2008 00:00:00
      Automated_description: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; identical protein binding activity; and protein heterodimerization activity. Involved in several processes, including apoptotic process; positive regulation of programmed cell death; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in excretory duct cell. Used to study acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in osteoporosis and stomach cancer. Is an ortholog of human DBP (D-box binding PAR bZIP transcription factor); HLF (HLF transcription factor, PAR bZIP family member); and TEF (TEF transcription factor, PAR bZIP family member). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:9952 Homo sapiens Paper_evidence: WBPaper00002515
          Curator_confirmed: WBPerson324
          Date_last_updated: 26 Oct 2018 00:00:00
    Potential_model: DOID:11476 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2697)
      DOID:10534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4977)
  Models_disease_asserted: WBDOannot00000241
  Molecular_info: Corresponding_CDS: ZK909.4
    Corresponding_transcript: ZK909.4.1
    Other_sequence: CRC07313_1
      Dviv_isotig25154
      JI177917.1
      CR05555
      JI167952.1
      GO250055.1
      JI169216.1
    Associated_feature: WBsf655757
      WBsf657146
      WBsf657147
      WBsf657148
      WBsf978677
      WBsf986281
      WBsf986282
      WBsf1011319
      WBsf1011320
      WBsf218845
    Gene_product_binds: WBsf019095
      WBsf019096
      WBsf019219
    Transcription_factor: WBTranscriptionFactor000051
  Experimental_info: RNAi_result: WBRNAi00027823 Inferred_automatically: RNAi_primary
      WBRNAi00095100 Inferred_automatically: RNAi_primary
      WBRNAi00113960 Inferred_automatically: RNAi_primary
      WBRNAi00115662 Inferred_automatically: RNAi_primary
      WBRNAi00059827 Inferred_automatically: RNAi_primary
      WBRNAi00004955 Inferred_automatically: RNAi_primary
      WBRNAi00095099 Inferred_automatically: RNAi_primary
      WBRNAi00107244 Inferred_automatically: RNAi_primary
      WBRNAi00116606 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr2959
      Expr10532
      Expr1020106
      Expr1030273
      Expr1163256
      Expr2009927
      Expr2028167
    Drives_construct: WBCnstr00011044
      WBCnstr00015519
      WBCnstr00018613
      WBCnstr00037513
    Construct_product: WBCnstr00015519
      WBCnstr00021934
      WBCnstr00037513
    Microarray_results (19)
    Expression_cluster (194)
    Interaction: WBInteraction000000451
      WBInteraction000000942
      WBInteraction000001004
      WBInteraction000001006
      WBInteraction000001012
      WBInteraction000002784
      WBInteraction000003766
      WBInteraction000003916
      WBInteraction000003990
      WBInteraction000003992
      WBInteraction000004012
      WBInteraction000004631
      WBInteraction000004632
      WBInteraction000004633
      WBInteraction000004634
      WBInteraction000004635
      WBInteraction000009818
      WBInteraction000029760
      WBInteraction000029940
      WBInteraction000030045
      WBInteraction000030056
      WBInteraction000030071
      WBInteraction000030090
      WBInteraction000030101
      WBInteraction000030102
      WBInteraction000030103
      WBInteraction000103362
      WBInteraction000105573
      WBInteraction000107377
      WBInteraction000108877
      WBInteraction000114691
      WBInteraction000115872
      WBInteraction000116017
      WBInteraction000117680
      WBInteraction000117779
      WBInteraction000118319
      WBInteraction000118634
      WBInteraction000118988
      WBInteraction000119097
      WBInteraction000121429
      WBInteraction000121526
      WBInteraction000121933
      WBInteraction000122180
      WBInteraction000124280
      WBInteraction000124799
      WBInteraction000125007
      WBInteraction000125955
      WBInteraction000126361
      WBInteraction000127089
      WBInteraction000133304
      WBInteraction000133476
      WBInteraction000133674
      WBInteraction000133684
      WBInteraction000134333
      WBInteraction000134571
      WBInteraction000135124
      WBInteraction000135802
      WBInteraction000137187
      WBInteraction000137488
      WBInteraction000137600
      WBInteraction000137957
      WBInteraction000139324
      WBInteraction000140447
      WBInteraction000141804
      WBInteraction000142383
      WBInteraction000142397
      WBInteraction000143409
      WBInteraction000144074
      WBInteraction000144640
      WBInteraction000145647
      WBInteraction000145867
      WBInteraction000146144
      WBInteraction000146154
      WBInteraction000147261
      WBInteraction000148230
      WBInteraction000149142
      WBInteraction000156889
      WBInteraction000157150
      WBInteraction000160561
      WBInteraction000160905
      WBInteraction000160991
      WBInteraction000161754
      WBInteraction000163581
      WBInteraction000164288
      WBInteraction000165513
      WBInteraction000165522
      WBInteraction000165536
      WBInteraction000165924
      WBInteraction000166019
      WBInteraction000170152
      WBInteraction000170706
      WBInteraction000170910
      WBInteraction000171530
      WBInteraction000174779
      WBInteraction000174891
      WBInteraction000180973
      WBInteraction000181346
      WBInteraction000183297
      WBInteraction000184186
      WBInteraction000184374
      WBInteraction000186027
      WBInteraction000188464
      WBInteraction000188490
      WBInteraction000190105
      WBInteraction000190526
      WBInteraction000191839
      WBInteraction000192039
      WBInteraction000195126
      WBInteraction000196006
      WBInteraction000197171
      WBInteraction000197398
      WBInteraction000198282
      WBInteraction000201146
      WBInteraction000201361
      WBInteraction000201581
      WBInteraction000203393
      WBInteraction000207095
      WBInteraction000208876
      WBInteraction000208880
      WBInteraction000209486
      WBInteraction000211504
      WBInteraction000212361
      WBInteraction000214364
      WBInteraction000218492
      WBInteraction000222337
      WBInteraction000229825
      WBInteraction000230011
      WBInteraction000231140
      WBInteraction000231491
      WBInteraction000233479
      WBInteraction000234526
      WBInteraction000236294
      WBInteraction000237396
      WBInteraction000241063
      WBInteraction000245539
      WBInteraction000245862
      WBInteraction000247522
      WBInteraction000248020
      WBInteraction000248219
      WBInteraction000248519
      WBInteraction000250600
      WBInteraction000251293
      WBInteraction000254144
      WBInteraction000257317
      WBInteraction000260602
      WBInteraction000261012
      WBInteraction000261805
      WBInteraction000263648
      WBInteraction000263704
      WBInteraction000267491
      WBInteraction000269662
      WBInteraction000273049
      WBInteraction000274915
      WBInteraction000274950
      WBInteraction000277122
      WBInteraction000280574
      WBInteraction000280875
      WBInteraction000281667
      WBInteraction000286799
      WBInteraction000287420
      WBInteraction000295034
      WBInteraction000299677
      WBInteraction000300635
      WBInteraction000302415
      WBInteraction000303198
      WBInteraction000303213
      WBInteraction000303611
      WBInteraction000305584
      WBInteraction000306446
      WBInteraction000309081
      WBInteraction000314294
      WBInteraction000315990
      WBInteraction000316932
      WBInteraction000316956
      WBInteraction000317162
      WBInteraction000319434
      WBInteraction000320104
      WBInteraction000320109
      WBInteraction000320539
      WBInteraction000321400
      WBInteraction000322994
      WBInteraction000323039
      WBInteraction000323253
      WBInteraction000329165
      WBInteraction000330155
      WBInteraction000332908
      WBInteraction000332987
      WBInteraction000335878
      WBInteraction000336010
      WBInteraction000342327
      WBInteraction000344581
      WBInteraction000347456
      WBInteraction000348696
      WBInteraction000351024
      WBInteraction000351818
      WBInteraction000357125
      WBInteraction000358676
      WBInteraction000359787
      WBInteraction000360909
      WBInteraction000365789
      WBInteraction000368040
      WBInteraction000368439
      WBInteraction000369984
      WBInteraction000372322
      WBInteraction000372891
      WBInteraction000377080
      WBInteraction000380093
      WBInteraction000380998
      WBInteraction000384077
      WBInteraction000384556
      WBInteraction000385232
      WBInteraction000385794
      WBInteraction000395863
      WBInteraction000396663
      WBInteraction000397023
      WBInteraction000398545
      WBInteraction000399684
      WBInteraction000403747
      WBInteraction000404406
      WBInteraction000407607
      WBInteraction000408526
      WBInteraction000411053
      WBInteraction000411214
      WBInteraction000411627
      WBInteraction000412313
      WBInteraction000415445
      WBInteraction000426426
      WBInteraction000426558
      WBInteraction000427420
      WBInteraction000427861
      WBInteraction000431345
      WBInteraction000433093
      WBInteraction000433947
      WBInteraction000434483
      WBInteraction000436530
      WBInteraction000436765
      WBInteraction000437180
      WBInteraction000438301
      WBInteraction000438511
      WBInteraction000440914
      WBInteraction000444581
      WBInteraction000448438
      WBInteraction000458742
      WBInteraction000459743
      WBInteraction000504029
      WBInteraction000504031
      WBInteraction000513164
      WBInteraction000513165
      WBInteraction000513166
      WBInteraction000513167
      WBInteraction000513168
      WBInteraction000513169
      WBInteraction000513170
      WBInteraction000513171
      WBInteraction000513172
      WBInteraction000513179
      WBInteraction000513181
      WBInteraction000513183
      WBInteraction000513184
      WBInteraction000523817
      WBInteraction000523825
      WBInteraction000523830
      WBInteraction000523831
      WBInteraction000523832
      WBInteraction000523833
      WBInteraction000523834
      WBInteraction000523835
      WBInteraction000523838
      WBInteraction000523848
      WBInteraction000525435
      WBInteraction000525557
      WBInteraction000525644
      WBInteraction000525645
      WBInteraction000525646
      WBInteraction000525647
      WBInteraction000525648
      WBInteraction000525649
      WBInteraction000525650
      WBInteraction000525651
      WBInteraction000525652
      WBInteraction000525653
      WBInteraction000525654
      WBInteraction000527244
      WBInteraction000527651
      WBInteraction000527696
      WBInteraction000527935
      WBInteraction000528681
      WBInteraction000529532
      WBInteraction000533110
      WBInteraction000535190
      WBInteraction000544694
      WBInteraction000544714
      WBInteraction000555866
  Map_info: Map: I Position: 28.8514 Error: 0.014285
    Well_ordered
    Positive: Positive_clone: C01F5
        ZK909 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 1238
        1239
        4455
      Pos_neg_data: 3215
        3216
        3217
        3218
        3219
        3739
        3740
        3741
        3742
  Reference (76)
  Method: Gene