WormBase Tree Display for Gene: WBGene00000411

WBGene00000411 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: R06F6
  Identity: Version: 1
    Name: CGC_name: cdl-1 Person_evidence: WBPerson634
      Sequence_name: R06F6.1
      Molecular_name: R06F6.1
        R06F6.1.1
        CE51537
      Other_name: hbp
        CELE_R06F6.1 Accession_evidence: NDB BX284602
      Public_name: cdl-1
    DB_info: Database (10)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:20 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cdl
    Allele (37)
    Legacy_information: [A Sugimoto] Cell Death Lethal. w37: (null) zygotic lethal, embryonic arrest with accumulated cell corpses, body elongation defect, pharynx not connected to buccal cavity. e2501, e2510: (possibly neomorphs) similar to w37, but more severe corpse accumulation and elongation defect.
    Strain: WBStrain00022736
      WBStrain00033878
      WBStrain00036242
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (35)
    Structured_description: Concise_description: cdl-1 encodes a homolog of human hairpin (stem-loop) binding proteins (HBP/SLBP) that bind to the hairpin (stem-loop) structure in the 3' untranslated region (3' UTR) of histone mRNAs, and thus promote histone pre-mRNA processing and translation of mature histone mRNA; CDL-1 is required for normally high levels of histone gene expression, normal cell division during late larval development, embryonic viability, normal vulval morphogenesis, normally rapid apoptosis, and fertility; CDL-1 binds to the stem-loop structure in the 3' UTR of core-histone mRNA; the cdl-1 promoter is most active in dividing cells during embryogenesis and postembryonic development; both CDL-1 and human HBP contain a minimal RNA-binding domain (RBD) of roughly 73 amino acids that has no similarity with other known RNA-binding motifs. Paper_evidence: WBPaper00004428
            WBPaper00005085
            WBPaper00005142
            WBPaper00013577
          Person_evidence: WBPerson1874
          Curator_confirmed: WBPerson13481
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables mRNA 3'-UTR binding activity. Involved in apoptotic process; embryo development; and mitotic chromosome condensation. Predicted to be located in cytoplasm. Predicted to be part of histone pre-mRNA 3'end processing complex. Expressed widely. Is an ortholog of human SLBP (stem-loop histone mRNA binding protein). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: R06F6.1
    Corresponding_CDS_history: R06F6.1:wp252
    Corresponding_transcript: R06F6.1.1
    Other_sequence (18)
    Associated_feature (12)
  Experimental_info: RNAi_result: WBRNAi00082051 Inferred_automatically: RNAi_primary
      WBRNAi00069364 Inferred_automatically: RNAi_primary
      WBRNAi00009038 Inferred_automatically: RNAi_primary
      WBRNAi00008237 Inferred_automatically: RNAi_primary
      WBRNAi00034665 Inferred_automatically: RNAi_primary
      WBRNAi00051393 Inferred_automatically: RNAi_primary
      WBRNAi00026046 Inferred_automatically: RNAi_primary
      WBRNAi00069365 Inferred_automatically: RNAi_primary
      WBRNAi00082056 Inferred_automatically: RNAi_primary
      WBRNAi00086822 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1840
      Expr10540
      Expr1028207
      Expr1030228
      Expr1155082
      Expr2009819
      Expr2028060
    Drives_construct: WBCnstr00010480
      WBCnstr00015525
      WBCnstr00037562
    Construct_product: WBCnstr00015525
      WBCnstr00037562
    Microarray_results (21)
    Expression_cluster (193)
    Interaction: WBInteraction000001553
      WBInteraction000001554
      WBInteraction000001555
      WBInteraction000001556
      WBInteraction000001557
      WBInteraction000009671
      WBInteraction000009815
      WBInteraction000028782
      WBInteraction000028992
      WBInteraction000030032
      WBInteraction000043756
      WBInteraction000049927
      WBInteraction000050022
      WBInteraction000136313
      WBInteraction000163258
      WBInteraction000165506
      WBInteraction000165507
      WBInteraction000165508
      WBInteraction000165520
      WBInteraction000165530
      WBInteraction000192543
      WBInteraction000194209
      WBInteraction000197899
      WBInteraction000202008
      WBInteraction000204662
      WBInteraction000208564
      WBInteraction000227001
      WBInteraction000229798
      WBInteraction000233338
      WBInteraction000235593
      WBInteraction000237160
      WBInteraction000242434
      WBInteraction000252864
      WBInteraction000255524
      WBInteraction000256828
      WBInteraction000257350
      WBInteraction000260095
      WBInteraction000262080
      WBInteraction000267248
      WBInteraction000267960
      WBInteraction000270574
      WBInteraction000282182
      WBInteraction000282937
      WBInteraction000285524
      WBInteraction000286469
      WBInteraction000288190
      WBInteraction000293364
      WBInteraction000293382
      WBInteraction000297373
      WBInteraction000297862
      WBInteraction000299671
      WBInteraction000299793
      WBInteraction000300826
      WBInteraction000304845
      WBInteraction000308591
      WBInteraction000308760
      WBInteraction000313267
      WBInteraction000313517
      WBInteraction000318262
      WBInteraction000325929
      WBInteraction000327231
      WBInteraction000328255
      WBInteraction000331060
      WBInteraction000332316
      WBInteraction000335270
      WBInteraction000336533
      WBInteraction000339192
      WBInteraction000339503
      WBInteraction000341938
      WBInteraction000345609
      WBInteraction000349576
      WBInteraction000351233
      WBInteraction000355498
      WBInteraction000363107
      WBInteraction000369237
      WBInteraction000373759
      WBInteraction000376305
      WBInteraction000379052
      WBInteraction000388968
      WBInteraction000389035
      WBInteraction000389056
      WBInteraction000393415
      WBInteraction000393885
      WBInteraction000400483
      WBInteraction000406227
      WBInteraction000406968
      WBInteraction000414263
      WBInteraction000415389
      WBInteraction000420994
      WBInteraction000424332
      WBInteraction000433680
      WBInteraction000437429
      WBInteraction000440734
      WBInteraction000443735
      WBInteraction000445007
      WBInteraction000450984
      WBInteraction000451035
      WBInteraction000452847
      WBInteraction000457789
      WBInteraction000458991
      WBInteraction000461815
      WBInteraction000518859
      WBInteraction000521672
      WBInteraction000521673
      WBInteraction000521674
      WBInteraction000523535
      WBInteraction000523536
      WBInteraction000559419
      WBInteraction000560700
      WBInteraction000565004
      WBInteraction000565483
      WBInteraction000566081
      WBInteraction000568027
      WBInteraction000568844
      WBInteraction000568932
      WBInteraction000570373
      WBInteraction000571440
      WBInteraction000574901
      WBInteraction000578920
      WBInteraction000578943
      WBInteraction000582234
      WBInteraction000584990
    WBProcess: WBbiopr:00000014
      WBbiopr:00000015
      WBbiopr:00000036
      WBbiopr:00000098
  Map_info: Map: II Position: 3.12577 Error: 0.000223
    Well_ordered
    Positive: Positive_clone: R06F6 Inferred_automatically: From sequence, transcript, pseudogene data
        T19E10 Person_evidence: WBPerson634
    Mapping_data: Multi_point: 4880
      Pos_neg_data: 10583
        10584
        10585
        10586
  Reference (22)
  Method: Gene