WormBase Tree Display for Gene: WBGene00001501

WBGene00001501 SMap: S_parent: Sequence: D1037
  Identity: Version: 1
    Name: CGC_name: ftn-2
      Sequence_name: D1037.3
      Molecular_name: D1037.3
        D1037.3.1
        CE20622
      Other_name: CELE_D1037.3 Accession_evidence: NDB BX284601
      Public_name: ftn-2
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:24 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: ftn
    Allele (16)
    Strain: WBStrain00002965
      WBStrain00031408
    RNASeq_FPKM (74)
    GO_annotation (17)
    Ortholog (74)
    Paralog: WBGene00001500 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
    Structured_description: Concise_description: ftn-2 encodes one of two C. elegans ferritin heavy chain homologs; loss of ftn-2 activity via deletion mutation results in slightly lower brood sizes and, under iron stress conditions, slightly faster growth from the L4 to adult stage of development, and slightly reduced lifespan; an ftn-2::gfp reporter fusion is expressed in diverse tissues, including the pharynx, intestine, and hypodermis, and its expression, along with that of ftn-2 mRNA, does not appear to change significantly under iron stress conditions. Paper_evidence: WBPaper00005703
            WBPaper00006525
            WBPaper00024456
          Curator_confirmed: WBPerson1843
            WBPerson1823
            WBPerson567
          Date_last_updated: 10 Mar 2006 00:00:00
      Automated_description: Enables identical protein binding activity. Involved in defense response to Gram-positive bacterium. Predicted to be located in cytoplasm. Expressed in body wall musculature and hypodermis. Human ortholog(s) of this gene implicated in several diseases, including hemochromatosis type 5; hyperferritinemia-cataract syndrome; and neurodegeneration with brain iron accumulation 3. Is an ortholog of human FTMT (ferritin mitochondrial). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3999)
      DOID:1289 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3999)
      DOID:0111031 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3976)
      DOID:0080600 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3976,HGNC:3999)
      DOID:0110737 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3999)
      DOID:679 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3999)
  Molecular_info: Corresponding_CDS: D1037.3
    Corresponding_transcript: D1037.3.1
    Other_sequence: EL887715.1
      CBC10112_1
      EX911069.1
      MJ00925
      ES410037.1
      AYC00089_2
      ES563591.1
      HBC18054_1
      ES742853.1
      TDC01809_1
      Hbac_isotig01033
      EX013124.1
      EX008877.1
      EX013638.1
      CR01087
      Tcol_isotig03912
      EX913831.1
      EX011809.1
      ZPC00072_1
      Acan_isotig11816
      FD514555.1
      EX544096.1
      ES564490.1
      LSC00687_1
      EX013228.1
      PE00357
      Tcol_isotig03911
      CB036805.1
      AYC00089_1
      RSC01269_1
      EX011225.1
      EX913122.1
      DA00225
      HC04904
      EX912681.1
      FC546408.1
      EX916455.1
      PPC00159_1
      RSC00164_1
      Tcol_isotig03913
      AE01308
      ES411750.1
      CJC05746_1
      TSC02405_1
      EX010915.1
      GW412852.1
      EX009542.1
      ES740145.1
      GO238935.1
      FD514557.1
      ES412962.1
      XIC00760_1
      Acan_contig07264
      EY460591.1
      FC554818.1
      PEC00395_1
      ACC10143_1
      HG09170
      ES409702.1
      GO250173.1
      RS07301
      Tcir_isotig03132
      BXC04872_1
      ES741627.1
      CSC00631_1
      XI03054
      Name_isotig02022
      PVC01087_1
      FD517063.1
      GP02922
      EY466651.1
      OOC02320_1
      EX010779.1
      ACC07738_1
      EX007880.1
      FD516633.1
      HGC02584_1
      CRC03595_1
      GPC01477_1
      DN557543.1
      HGC06193_1
      DN557604.1
      ES291034.1
      HG03372
      BUC00387_1
      PPC16612_1
      GO252030.1
      MHC08568_1
      AS01507
      HCC01982_1
      HC04479
      XIC02420_1
      Dviv_isotig28567
      MJC00448_1
      PSC03125_1
      EX014348.1
      BMC06485_1
      EX013863.1
      ES743543.1
      MH10214
      XI03413
      AS16792
      TS03418
      ES410324.1
      ES741097.1
      GO249646.1
      EX009226.1
      EX009470.1
      RS05914
      XI01112
      ES743847.1
      CR09341
      EX910642.1
      Oden_isotig22702
      CV200280.1
      Acan_isotig07186
      PP00481
      Tcir_isotig28178
      JI178454.1
      EX015128.1
      DAC01922_1
      XIC03001_1
      HCC02904_1
      ZP00142
      EX014610.1
      EX912314.1
      EX007629.1
      Tcir_isotig03131
      FM207815.1
      EX914246.1
      EX539578.1
      Tcir_isotig31425
      AE00093
      ASC21266_1
      ES742830.1
      FD514558.1
      CBC01577_1
      HC02077
      EX913699.1
      ACC00325_1
      FD514955.1
      EX544353.1
      GRC00729_1
      FD516347.1
      EX915269.1
      HBC00323_1
      CJC00088_1
      GO249214.1
      HBC01507_1
      AE00955
      EX910881.1
      EX013952.1
      ES410084.1
      ACC26993_1
      PPC08273_1
    Associated_feature (16)
  Experimental_info: RNAi_result: WBRNAi00089360 Inferred_automatically: RNAi_primary
      WBRNAi00102059 Inferred_automatically: RNAi_primary
      WBRNAi00116826 Inferred_automatically: RNAi_primary
      WBRNAi00033297 Inferred_automatically: RNAi_primary
      WBRNAi00102060 Inferred_automatically: RNAi_primary
      WBRNAi00003267 Inferred_automatically: RNAi_primary
      WBRNAi00069754 Inferred_automatically: RNAi_primary
      WBRNAi00043364 Inferred_automatically: RNAi_primary
      WBRNAi00067721 Inferred_automatically: RNAi_primary
      WBRNAi00089349 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1229
      Expr3081
      Expr4744
      Expr5610
      Expr7855
      Expr1022759
      Expr1030901
      Expr1147349
      Expr2011914
      Expr2030151
    Drives_construct: WBCnstr00003471
      WBCnstr00009029
      WBCnstr00011121
      WBCnstr00012954
      WBCnstr00016205
      WBCnstr00036907
    Construct_product: WBCnstr00011121
      WBCnstr00036907
    Antibody: WBAntibody00002946
    Microarray_results (23)
    Expression_cluster (215)
    Interaction: WBInteraction000007175
      WBInteraction000028655
      WBInteraction000029496
      WBInteraction000030563
      WBInteraction000030564
      WBInteraction000030565
      WBInteraction000030566
      WBInteraction000030567
      WBInteraction000126515
      WBInteraction000126516
      WBInteraction000176337
      WBInteraction000181571
      WBInteraction000211846
      WBInteraction000212469
      WBInteraction000216433
      WBInteraction000218124
      WBInteraction000223886
      WBInteraction000230679
      WBInteraction000237123
      WBInteraction000251476
      WBInteraction000259769
      WBInteraction000280772
      WBInteraction000288935
      WBInteraction000336172
      WBInteraction000337753
      WBInteraction000353980
      WBInteraction000358607
      WBInteraction000378163
      WBInteraction000381648
      WBInteraction000384143
      WBInteraction000384144
      WBInteraction000384165
      WBInteraction000417689
      WBInteraction000455289
      WBInteraction000456418
      WBInteraction000458142
      WBInteraction000470582
      WBInteraction000474251
      WBInteraction000501832
      WBInteraction000504938
      WBInteraction000505195
      WBInteraction000506039
      WBInteraction000506063
      WBInteraction000506075
      WBInteraction000506636
      WBInteraction000506638
      WBInteraction000506639
      WBInteraction000506640
      WBInteraction000506641
      WBInteraction000506642
      WBInteraction000506644
      WBInteraction000506645
      WBInteraction000506646
      WBInteraction000506648
      WBInteraction000506649
      WBInteraction000506650
      WBInteraction000506651
      WBInteraction000506652
      WBInteraction000506653
      WBInteraction000506654
      WBInteraction000506655
      WBInteraction000506656
      WBInteraction000506657
      WBInteraction000506658
      WBInteraction000506659
      WBInteraction000506660
      WBInteraction000506662
      WBInteraction000506664
      WBInteraction000506668
      WBInteraction000507869
      WBInteraction000507870
      WBInteraction000507871
      WBInteraction000507872
      WBInteraction000507873
      WBInteraction000507874
      WBInteraction000507875
      WBInteraction000507876
      WBInteraction000507877
      WBInteraction000507878
      WBInteraction000507879
      WBInteraction000507880
      WBInteraction000507881
      WBInteraction000507882
      WBInteraction000507883
      WBInteraction000507884
      WBInteraction000507885
      WBInteraction000507886
      WBInteraction000507887
      WBInteraction000507888
      WBInteraction000507889
      WBInteraction000507890
      WBInteraction000507891
      WBInteraction000507892
      WBInteraction000507893
      WBInteraction000507894
      WBInteraction000507895
      WBInteraction000507896
      WBInteraction000507897
      WBInteraction000507898
      WBInteraction000507899
      WBInteraction000507900
      WBInteraction000507901
      WBInteraction000507902
      WBInteraction000507903
      WBInteraction000507904
      WBInteraction000507905
      WBInteraction000507906
      WBInteraction000507907
      WBInteraction000507908
      WBInteraction000507909
      WBInteraction000507910
      WBInteraction000507911
      WBInteraction000507912
      WBInteraction000507913
      WBInteraction000507914
      WBInteraction000507915
      WBInteraction000507916
      WBInteraction000507917
      WBInteraction000507918
      WBInteraction000507919
      WBInteraction000507920
      WBInteraction000507921
      WBInteraction000507922
      WBInteraction000512432
      WBInteraction000512433
      WBInteraction000512434
      WBInteraction000512435
      WBInteraction000512436
      WBInteraction000512437
      WBInteraction000512438
      WBInteraction000512439
      WBInteraction000512440
      WBInteraction000512441
      WBInteraction000512442
      WBInteraction000512443
      WBInteraction000512444
      WBInteraction000512445
      WBInteraction000512446
      WBInteraction000512447
      WBInteraction000512448
      WBInteraction000512449
      WBInteraction000512450
      WBInteraction000512451
      WBInteraction000512452
      WBInteraction000512453
      WBInteraction000512454
      WBInteraction000512455
      WBInteraction000512456
      WBInteraction000512457
      WBInteraction000512458
      WBInteraction000512459
      WBInteraction000512460
      WBInteraction000512461
      WBInteraction000512462
      WBInteraction000512463
      WBInteraction000512464
      WBInteraction000512465
      WBInteraction000512466
      WBInteraction000512467
      WBInteraction000512468
      WBInteraction000512469
      WBInteraction000512471
      WBInteraction000512472
      WBInteraction000512473
      WBInteraction000512527
      WBInteraction000514571
      WBInteraction000514572
      WBInteraction000514573
      WBInteraction000514574
      WBInteraction000514575
      WBInteraction000514576
      WBInteraction000514577
      WBInteraction000514578
      WBInteraction000514580
      WBInteraction000514581
      WBInteraction000514582
      WBInteraction000514583
      WBInteraction000516145
      WBInteraction000521660
      WBInteraction000521661
      WBInteraction000524099
      WBInteraction000524100
      WBInteraction000524102
      WBInteraction000524518
      WBInteraction000524544
      WBInteraction000546362
      WBInteraction000546542
      WBInteraction000547337
      WBInteraction000547595
      WBInteraction000547607
      WBInteraction000555043
      WBInteraction000562008
      WBInteraction000566807
      WBInteraction000570286
      WBInteraction000571109
      WBInteraction000572328
      WBInteraction000577566
      WBInteraction000580003
      WBInteraction000586228
      WBInteraction000586230
      WBInteraction000586231
      WBInteraction000586393
    WBProcess: WBbiopr:00000039
      WBbiopr:00000096
  Map_info: Map: I Position: -2.93309 Error: 0.018064
    Positive: Positive_clone: D1037 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4327
        4429
        4670
    Pseudo_map_position
  Reference (21)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene