WormBase Tree Display for Gene: WBGene00006804
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| WBGene00006804 | SMap | S_parent | Sequence | Y37D8A | |||
|---|---|---|---|---|---|---|---|
| Identity (6) | |||||||
| Gene_info | Biotype | SO:0001217 | |||||
| Gene_class | unc | ||||||
| Reference_allele | WBVar00143287 | ||||||
| Allele (187) | |||||||
| Legacy_information | e541 : strong kinker especially in reverse fairly active; commissures sometimes on wrong side. ES3 ME2. NA1. | ||||||
| [C.elegansII] e541 : strong kinker, especially in reverse; fairly active; commissures sometimes on wrong side; variable defects in axonal elongation and fasciculation; synergizes with sem-5(n1779) to give Sem migration defect. ES3 ME2. OA1: ay7.YAC rescue (Y37D8)[McIntire et al. 1992; Garriga and Stern 1994; NG; NH] | |||||||
| [C.elegansII] NMK. Sequence predicts protein with extensive similarity to ADAM (disintegrin plus metalloprotease domains) family. [CB] | |||||||
| Strain | WBStrain00004180 | ||||||
| WBStrain00005370 | |||||||
| WBStrain00005371 | |||||||
| WBStrain00006386 | |||||||
| RNASeq_FPKM (74) | |||||||
| GO_annotation (13) | |||||||
| Ortholog (58) | |||||||
| Paralog | WBGene00000074 | Caenorhabditis elegans | From_analysis | TreeFam | |||
| Panther | |||||||
| WormBase-Compara | |||||||
| WBGene00000075 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
| WormBase-Compara | |||||||
| WBGene00006324 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
| WBGene00016423 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
| WBGene00019514 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
| Structured_description | Concise_description | unc-71 encodes an ADAM, a disintegrin and metalloprotease-containing transmembrane protein that is a member of the metzincin superfamily of proteases; UNC-71 is required non-cell autonomously for motor axon guidance and sex myoblast migration; UNC-71 does not appear to have an active metalloprotease domain, but functions with UNC-6/netrin and integrins INA-1/PAT-3 to provide guidance cues during axonal migration; UNC-71 is expressed in a restricted pattern in the excretory and excretory gland cells, some head neurons, the sphincter muscles, and hypodermal cells surrounding the vulva. | Paper_evidence | WBPaper00002626 | |||
| WBPaper00004116 | |||||||
| WBPaper00005955 | |||||||
| Curator_confirmed | WBPerson1843 | ||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
| Automated_description | Predicted to enable metalloendopeptidase activity. Predicted to be involved in membrane protein ectodomain proteolysis. Located in membrane. Expressed in several structures, including buccal cavity; excretory system; nerve ring; neuronal sheath cell; and neurons. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 61. Is an ortholog of human ADAM22 (ADAM metallopeptidase domain 22) and ADAM23 (ADAM metallopeptidase domain 23). | Paper_evidence | WBPaper00065943 | ||||
| Curator_confirmed | WBPerson324 | ||||||
| WBPerson37462 | |||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
| Disease_info | Potential_model | DOID:0080434 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:201) | ||
| Molecular_info | Corresponding_CDS | Y37D8A.13 | |||||
| Corresponding_CDS_history | Y37D8A.13a:wp264 | ||||||
| Y37D8A.13b:wp264 | |||||||
| Corresponding_transcript | Y37D8A.13.1 | ||||||
| Other_sequence (38) | |||||||
| Associated_feature (13) | |||||||
| Experimental_info | RNAi_result (17) | ||||||
| Expr_pattern | Expr593 | ||||||
| Expr594 | |||||||
| Expr595 | |||||||
| Expr2572 | |||||||
| Expr2573 | |||||||
| Expr1023584 | |||||||
| Expr1032872 | |||||||
| Expr1159397 | |||||||
| Expr2017902 | |||||||
| Expr2036038 | |||||||
| Drives_construct | WBCnstr00000731 | ||||||
| Construct_product | WBCnstr00010859 | ||||||
| Antibody | WBAntibody00000138 | ||||||
| WBAntibody00000139 | |||||||
| Microarray_results (20) | |||||||
| Expression_cluster (183) | |||||||
| Interaction (78) | |||||||
| Map_info | Map | III | Position | 19.2806 | Error | 0.088498 | |
| Well_ordered | |||||||
| Positive | Inside_rearr | mT1 | |||||
| Positive_clone | Y37D8 | Person_evidence | WBPerson911 | ||||
| WBPerson493 | |||||||
| Y37D8A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Y52B8 | Person_evidence | WBPerson911 | |||||
| Mapping_data | 2_point | 76 | |||||
| 88 | |||||||
| 4235 | |||||||
| Multi_point | 63 | ||||||
| 256 | |||||||
| 1505 | |||||||
| 1660 | |||||||
| 3113 | |||||||
| 3114 | |||||||
| 3263 | |||||||
| 3510 | |||||||
| Pos_neg_data | 353 | ||||||
| 5733 | |||||||
| 4720 | |||||||
| 8379 | |||||||
| 8390 | |||||||
| 8551 | |||||||
| Reference (71) | |||||||
| Remark (4) | |||||||
| Method | Gene |
