WormBase Tree Display for Gene: WBGene00000074
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| WBGene00000074 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | adm-2 | Person_evidence | WBPerson493 | |||||
| Sequence_name | C04A11.4 | ||||||||
| Molecular_name | C04A11.4a | ||||||||
| C04A11.4a.1 | |||||||||
| CE07906 | |||||||||
| C04A11.4b | |||||||||
| CE52805 | |||||||||
| C04A11.4b.1 | |||||||||
| Other_name | CELE_C04A11.4 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | adm-2 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | adm | ||||||||
| Allele (182) | |||||||||
| Strain | WBStrain00033018 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (17) | |||||||||
| Ortholog (56) | |||||||||
| Paralog | WBGene00006804 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000075 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| WormBase-Compara | |||||||||
| WBGene00006324 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00016423 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00019514 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | adm-2 encodes a protein containing a snake venom disintegrin-domain and a metalloprotease-like domain (i.e., a protein of the ADAM family); like ADM-1, ADM-2 is homologous to a mammalian sperm glycoprotein (PH-30/fertilin) implicated in sperm-egg fusion, and ADM-2 might thus be a fusogenic protein mediating the merging of plasma membranes during development. | Paper_evidence | WBPaper00002626 | |||||
| WBPaper00012780 | |||||||||
| WBPaper00012947 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable metalloendopeptidase activity. Predicted to be involved in membrane protein ectodomain proteolysis. Predicted to be located in endosome membrane; lysosomal membrane; and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); endocrine gland cancer (multiple); and lung disease (multiple). Is an ortholog of human ADAM19 (ADAM metallopeptidase domain 19) and ADAM33 (ADAM metallopeptidase domain 33). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (18) | ||||||||
| Molecular_info | Corresponding_CDS | C04A11.4a | |||||||
| C04A11.4b | |||||||||
| Corresponding_transcript | C04A11.4a.1 | ||||||||
| C04A11.4b.1 | |||||||||
| Other_sequence (12) | |||||||||
| Associated_feature | WBsf663500 | ||||||||
| WBsf1007698 | |||||||||
| WBsf1007699 | |||||||||
| WBsf1007700 | |||||||||
| WBsf1007701 | |||||||||
| WBsf1024282 | |||||||||
| WBsf1024283 | |||||||||
| WBsf1024284 | |||||||||
| WBsf236598 | |||||||||
| WBsf236599 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr1014279 | ||||||||
| Expr1030033 | |||||||||
| Expr1143671 | |||||||||
| Expr2009235 | |||||||||
| Expr2027472 | |||||||||
| Drives_construct | WBCnstr00037750 | ||||||||
| Construct_product | WBCnstr00037750 | ||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (136) | |||||||||
| Interaction (15) | |||||||||
| Map_info | Map | X | Position | 14.3412 | Error | 0.068825 | |||
| Positive | Positive_clone | C04A11 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4143 | |||||||
| 4898 | |||||||||
| 5297 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (14) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
