WormBase Tree Display for Gene: WBGene00006777
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WBGene00006777 | SMap | S_parent | Sequence | C27H6 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | unc-41 | Person_evidence | WBPerson261 | |||
Sequence_name | C27H6.1 | ||||||
Molecular_name | C27H6.1a | ||||||
C27H6.1a.1 | |||||||
CE45344 | |||||||
C27H6.1b | |||||||
CE45373 | |||||||
C27H6.1c | |||||||
CE45298 | |||||||
C27H6.1b.1 | |||||||
C27H6.1c.1 | |||||||
Other_name | tcf-1 | ||||||
apt-10 | Person_evidence | WBPerson625 | |||||
CELE_C27H6.1 | Accession_evidence | NDB | BX284605 | ||||
Public_name | unc-41 | ||||||
DB_info | Database | WormQTL | gene | WBGene00006777 | |||
SignaLink | protein | WBGene00006777 | |||||
WormFlux | gene | WBGene00006777 | |||||
NDB | locus_tag | CELE_C27H6.1 | |||||
Panther | gene | CAEEL|WormBase=WBGene00006777|UniProtKB=P90761 | |||||
family | PTHR10529 | ||||||
NCBI | gene | 179387 | |||||
RefSeq | protein | NM_001269229.3 | |||||
NM_001269228.3 | |||||||
NM_001269230.3 | |||||||
SwissProt | UniProtAcc | P90761 | |||||
TREEFAM | TREEFAM_ID | TF300393 | |||||
UniProt_GCRP | UniProtAcc | P90761 | |||||
Species | Caenorhabditis elegans | ||||||
History (2) | |||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | unc | ||||||
Reference_allele | WBVar00143075 | ||||||
Allele (176) | |||||||
Legacy_information | e268 : weak kinker irregular jerky movement slightly small; VD1 VD2 DD1 cell bodies mispositioned usually anteriorly; RVG organization disrupted. ES3 ME0. NA9 (e252 e399 etc.). Similar phenotype in e262/Df. | ||||||
See also e1573 | |||||||
[C.elegansII] e268 : weak kinker, irregular jerky movement, slightly small; VD1, VD2, DD1 cell bodies mispositioned, usually anteriorly; RVG organization disrupted; Ric; elevated acetycholine levels. e268/Df similar.ES3 ME0. OA8: e252, e399, e1175, e1294,cn252::Tc1 etc.(similar). Also anomalous alleles: e554, e1162 (normal acetylcholinelevels, larger size, sd Unc phenotype.) Cloned: partial sequence indicates novel predicted protein. [Nguyen et al. 1995; RM; TN] | |||||||
Strain | WBStrain00002568 | ||||||
WBStrain00033383 | |||||||
WBStrain00033384 | |||||||
WBStrain00033407 | |||||||
WBStrain00033413 | |||||||
WBStrain00004269 | |||||||
WBStrain00004387 | |||||||
WBStrain00004139 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (13) | |||||||
Ortholog (42) | |||||||
Paralog | WBGene00000150 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00001082 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00006829 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00000164 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | unc-41 encodes an ortholog of Drosophila STONED B (STNB) required for normal locomotion; a beta-strand in the mu-adaptin-like domain of UNC-41 binds the C2A domain of SNT-1, and this binding is required for SNT-1 endocytosis, punctate localization of UNC-41 in neurons, and transgenic rescue of unc-41(e268) animals; UNC-41 is also required for normal secretion of EGL-17 from P6.p cells, and for embryonic viability; UNC-41 is expressed in the larval and adult nervous system; UNC-41, like other stonins, is an adaptin, and by orthology with stonins is predicted to be a protein adaptor that helps sort SNT-1 endocytotically. | Paper_evidence | WBPaper00004907 | |||
WBPaper00006219 | |||||||
WBPaper00006525 | |||||||
WBPaper00013412 | |||||||
WBPaper00031006 | |||||||
WBPaper00031369 | |||||||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 06 Feb 2008 00:00:00 | ||||||
Automated_description | Predicted to enable clathrin adaptor activity. Involved in positive regulation of locomotion. Located in synapse. Expressed in DD neuron; VD neuron; and cholinergic neurons. Is an ortholog of human STON2 (stonin 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | C27H6.1a | |||||
C27H6.1b | |||||||
C27H6.1c | |||||||
Corresponding_CDS_history | C27H6.1:wp218 | ||||||
Corresponding_transcript | C27H6.1a.1 | ||||||
C27H6.1b.1 | |||||||
C27H6.1c.1 | |||||||
Other_sequence (37) | |||||||
Associated_feature (14) | |||||||
Experimental_info | RNAi_result | WBRNAi00089949 | Inferred_automatically | RNAi_primary | |||
WBRNAi00063263 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00090109 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00062995 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00089721 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00063002 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00011280 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00090267 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00041380 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00098506 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (11) | |||||||
Drives_construct | WBCnstr00003130 | ||||||
WBCnstr00012971 | |||||||
WBCnstr00015493 | |||||||
WBCnstr00015494 | |||||||
Construct_product | WBCnstr00012971 | ||||||
Antibody | WBAntibody00002355 | ||||||
Microarray_results (22) | |||||||
Expression_cluster (235) | |||||||
Interaction (23) | |||||||
Map_info | Map | V | Position | 2.22339 | Error | 0.000715 | |
Well_ordered | |||||||
Positive (2) | |||||||
Mapping_data | 2_point | 131 | |||||
139 | |||||||
947 | |||||||
Multi_point (18) | |||||||
Pos_neg_data | 307 | ||||||
857 | |||||||
865 | |||||||
1739 | |||||||
1763 | |||||||
2170 | |||||||
3074 | |||||||
3113 | |||||||
Reference (43) | |||||||
Method | Gene |