WormBase Tree Display for Gene: WBGene00003172
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| WBGene00003172 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name (5) | |||||||||
| DB_info | Database | AceView | gene | 1K18 | |||||
| WormQTL | gene | WBGene00003172 | |||||||
| WormFlux | gene | WBGene00003172 | |||||||
| NDB | locus_tag | CELE_F46A9.6 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00003172|UniProtKB=G5ECJ4 | |||||||
| family | PTHR10501 | ||||||||
| NCBI | gene | 172771 | |||||||
| RefSeq | protein | NM_060107.7 | |||||||
| TREEFAM | TREEFAM_ID | TF351070 | |||||||
| TrEMBL | UniProtAcc | G5ECJ4 | |||||||
| UniProt_GCRP | UniProtAcc | G5ECJ4 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mec | ||||||||
| Reference_allele | WBVar00143178 | ||||||||
| Allele (56) | |||||||||
| Legacy_information | e398amber : touch insensitive lethargic; disrupted fasciculation of amphid channel cilia. ES2 ME2. NA6. | ||||||||
| See also e398 | |||||||||
| [C.elegansII] e398amb : touch insensitive lethargic; disrupted fasciculation of amphid and phasmid channelcilia; Dyf. Synthetic lethal with some unc-52(e444); Pat. ES2 ME2. NA16:mn364 (recessive lethal, Pat), mn412 (Mel, Gro). u74, u456, rh170, mn472, u391. See also smu. Cloned: encodes protein with two copies of RNP predicted RNA binding domain. [Perkins et al. 1986; Lundquist and Herman 1994; SP; NJ; EH; TU] | |||||||||
| Strain (14) | |||||||||
| In_cluster | conserved_miRNA_siRNA_cluster | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Ortholog (47) | |||||||||
| Paralog | WBGene00004386 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WBGene00004385 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| Structured_description | Concise_description | mec-8 encodes a protein with two RNA recognition motifs (RRM); mec-8 is required for proper development of body wall muscle and chemosensory and touch receptor neurons and as a result, for embryonic and larval development, sensory neuron fasciculation, and mechanosensation; MEC-8 functions as an mRNA processing factor whose activity is required for alternative splicing of genes such as unc-52/perlecan, with which it interacts genetically to produce synthetic lethality at the two-fold stage of embryonic elongation; mec-8 mutations also exhibit synthetic lethality with mutations in a number of other genes, including the sym genes and daf-18; mec-8; unc-52 synthetic lethality is suppressed by mutations in smu-1 and smu-2 which both encode homologs of mammalian spliceosome-associated proteins; mec-8 is broadly expressed in the embryo and expressed in hypodermal and neuronal tissues in larvae. | Paper_evidence | WBPaper00000502 | |||||
| WBPaper00000932 | |||||||||
| WBPaper00002016 | |||||||||
| WBPaper00002458 | |||||||||
| WBPaper00003663 | |||||||||
| WBPaper00005568 | |||||||||
| WBPaper00024639 | |||||||||
| WBPaper00027108 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 04 Sep 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable mRNA binding activity. Involved in several processes, including hemidesmosome assembly; mechanosensory behavior; and nematode larval development. Located in nucleus. Expressed in several structures, including head muscle; hypodermis; and vulva. Is an ortholog of human RBPMS (RNA binding protein, mRNA processing factor) and RBPMS2 (RNA binding protein, mRNA processing factor 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F46A9.6 | |||||||
| Corresponding_transcript | F46A9.6.1 | ||||||||
| F46A9.6.2 | |||||||||
| Other_sequence (24) | |||||||||
| Associated_feature (31) | |||||||||
| Gene_product_binds | WBsf047657 | ||||||||
| WBsf047658 | |||||||||
| Experimental_info | RNAi_result (14) | ||||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00002454 | ||||||||
| WBCnstr00006517 | |||||||||
| WBCnstr00010759 | |||||||||
| WBCnstr00036198 | |||||||||
| WBCnstr00041290 | |||||||||
| WBCnstr00042667 | |||||||||
| Construct_product | WBCnstr00006517 | ||||||||
| WBCnstr00010759 | |||||||||
| WBCnstr00016049 | |||||||||
| WBCnstr00036198 | |||||||||
| WBCnstr00041290 | |||||||||
| WBCnstr00042667 | |||||||||
| Regulate_expr_cluster | WBPaper00062197:mec-8_downregulated | ||||||||
| WBPaper00062197:mec-8_downregulated_TRN | |||||||||
| WBPaper00062197:mec-8_upregulated | |||||||||
| WBPaper00062197:mec-8_upregulated_TRN | |||||||||
| Antibody | WBAntibody00000576 | ||||||||
| Microarray_results (26) | |||||||||
| Expression_cluster (163) | |||||||||
| Interaction (185) | |||||||||
| Map_info | Map | I | Position | 3.76436 | Error | 0.0003 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C17E4 | |||||||
| C34A2 | |||||||||
| F46A9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point | 27 | |||||||
| 5741 | |||||||||
| Multi_point (14) | |||||||||
| Pos_neg_data (18) | |||||||||
| Reference (119) | |||||||||
| Remark | [Lundquist EA] I'm quite certain that these polymorphisms are defects in the mec-8 gene. u456 and rh170 are small deletions of the same 2.5kb HIII fragment, u391 is a complex rearrangement that has a breakpoint in the same 2.5kb HIII fragment, and mn472 is a Tc1 insertion into the same 2.5kb HIII fragment. Furthermore, the area of these cosmids on the physical map is in good agreement with the genetic map position of mec-8. Rescue is hopefully on the way. | ||||||||
| Method | Gene |
