WormBase Tree Display for Gene: WBGene00004385
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| WBGene00004385 | Evidence | Person_evidence | WBPerson71 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| WBPerson395 | |||||||||
| SMap | S_parent | Sequence | K08D10 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | rnp-2 | Person_evidence | WBPerson421 | |||||
| Sequence_name | K08D10.4 | ||||||||
| Molecular_name | K08D10.4 | ||||||||
| K08D10.4.1 | |||||||||
| CE28597 | |||||||||
| Other_name | CELE_K08D10.4 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | rnp-2 | ||||||||
| DB_info | Database | AceView | gene | 4E937 | |||||
| WormQTL | gene | WBGene00004385 | |||||||
| WormFlux | gene | WBGene00004385 | |||||||
| NDB | locus_tag | CELE_K08D10.4 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004385|UniProtKB=Q21322 | |||||||
| family | PTHR10501 | ||||||||
| NCBI | gene | 177181 | |||||||
| RefSeq | protein | NM_068103.5 | |||||||
| TREEFAM | TREEFAM_ID | TF313834 | |||||||
| TrEMBL | UniProtAcc | Q21322 | |||||||
| UniProt_GCRP | UniProtAcc | Q21322 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:35 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | rnp | ||||||||
| Allele (53) | |||||||||
| Strain | WBStrain00003826 | ||||||||
| WBStrain00003827 | |||||||||
| WBStrain00003828 | |||||||||
| WBStrain00007975 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00071282 | ||||||||
| 00071283 | |||||||||
| 00071284 | |||||||||
| 00071285 | |||||||||
| 00071286 | |||||||||
| 00112745 | |||||||||
| 00112746 | |||||||||
| Contained_in_operon | CEOP4116 | ||||||||
| Ortholog (39) | |||||||||
| Paralog | WBGene00003172 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WBGene00004386 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | rnp-2 encodes the small nuclear ribonucleoprotein (snRNP)-associated protein RNP-2/U1A, which associates with U1 snRNPs; rnp-2 is coexpressed with rnp-3, dnj-15, and K08D10.12 in an operon; RNP-2 and RNP-3 are paralogs with ~50% identity that are more closely related to one another than to non-nematode orthologs; despite their association with distinct snRNPs, RNP-2 and RNP-3 are functionally interchangeable in vivo; either rnp-2(RNAi) or rnp-3(ok1424) animals are viable, with only rnp-2(RNAi) rnp-3(ok1424) animals showing lethality; moreover, RNAi against only RNP-3 causes RNP-2 to associate with RNP-3's normal U2 snRNP partners. | Paper_evidence | WBPaper00005959 | |||||
| WBPaper00029444 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 06 Jun 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable U1 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be part of U1 snRNP. Human ortholog(s) of this gene implicated in Alzheimer's disease; connective tissue disease; and disease of cellular proliferation. Is an ortholog of human SNRPA (small nuclear ribonucleoprotein polypeptide A) and SNRPB2 (small nuclear ribonucleoprotein polypeptide B2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10652 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11151) | ||||
| DOID:14566 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11155) | ||||||
| DOID:65 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11151,HGNC:11155) | ||||||
| Molecular_info | Corresponding_CDS | K08D10.4 | |||||||
| Corresponding_transcript | K08D10.4.1 | ||||||||
| Other_sequence (47) | |||||||||
| Associated_feature | WBsf645908 | ||||||||
| WBsf659785 | |||||||||
| WBsf996195 | |||||||||
| WBsf228165 | |||||||||
| Experimental_info | RNAi_result (19) | ||||||||
| Expr_pattern | Expr1012050 | ||||||||
| Expr1032196 | |||||||||
| Expr1153952 | |||||||||
| Expr2015391 | |||||||||
| Expr2033625 | |||||||||
| Drives_construct | WBCnstr00000641 | ||||||||
| WBCnstr00000642 | |||||||||
| WBCnstr00035521 | |||||||||
| Construct_product | WBCnstr00000641 | ||||||||
| WBCnstr00000642 | |||||||||
| WBCnstr00035521 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (98) | |||||||||
| Interaction (132) | |||||||||
| Map_info | Map | IV | Position | -0.469588 | Error | 0.052915 | |||
| Positive | Positive_clone | K08D10 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4746 | |||||||
| 4997 | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00026593 | ||||||||
| WBPaper00029444 | |||||||||
| WBPaper00030488 | |||||||||
| WBPaper00038354 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00054464 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00065026 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
