WormBase Tree Display for Gene: WBGene00002285

WBGene00002285 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: C05G5
  Identity (6)
  Gene_info: Biotype: SO:0001265
    Gene_class: let
    Reference_allele: WBVar00089036
    Allele (51)
    Possibly_affected_by: WBVar02157918
      WBVar02157919
    Legacy_information: mn112 : late larval lethal XX animals die at early L3 XO die at late L4. NA1.
      [C.elegansII] mn112 : late larval lethal, XX animals die at early L3; XO die at late L4. OA1: mn107 (sterile). [Meneely and Herman 1981; SP]
    Strain: WBStrain00027302
      WBStrain00029077
      WBStrain00029078
      WBStrain00030773
      WBStrain00030774
      WBStrain00034162
      WBStrain00007921
      WBStrain00007922
      WBStrain00007936
      WBStrain00051615
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog: WBGene00233297 Brugia malayi Accession_evidence: miRBase MI0013319
    Structured_description: Concise_description: let-7 encodes a 21-nucleotide microRNA (also known as a small temporal RNA, or stRNA) that is conserved in bilateral animal species (including vertebrates, ascidians, hemichordates, molluscs, annelids and arthropods), but is not found in cnidarians, poriferans, fungi, plants, protists, archaea, or bacteria; let-7 is required for the transition from late larval to adult cell fates, and for larval viability; like lin-4, let-7 is complementary to sequences in the 3' untranslated regions of target genes that it negatively regulates; let-7 RNA expression is first detected at late larval stages and is negatively regulated by the product of one of its targets, hbl-1, in a negative feedback loop; the temporal regulatory element (TRE), situated about 1200 base pairs upstream of the start of the mature let-7 RNA, is both necessary and sufficient for temporal upregulation of let-7 transcription; DCR-1, ALG-1, and ALG-2 are required for the maturation and activity of let-7 stRNA; since let-7 homologs are expressed in zebrafish embryos and in adult annelids and molluscs, let-7 may have a conserved function in heterochronic developmental regulation in bilateria. Paper_evidence: WBPaper00004399
            WBPaper00004772
            WBPaper00004775
            WBPaper00005971
            WBPaper00028966
            WBPaper00034754
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 20 Aug 2009 00:00:00
      Automated_description: Enables mRNA 3'-UTR binding activity. Involved in several processes, including negative regulation of Ras protein signal transduction; negative regulation of gene expression; and regulation of development, heterochronic. Part of RISC complex. Expressed in several structures, including gonad; hypodermis; somatic nervous system; touch receptor neurons; and vulval precursor cell. Used to study cancer. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:162 Homo sapiens Paper_evidence: WBPaper00003929
          Curator_confirmed: WBPerson324
          Date_last_updated: 25 Oct 2018 00:00:00
    Disease_relevance: let-7 microRNA (miRNA) is highly conserved across species, from C. elegans to humans; there are at least 13 different let-7 family members in humans, C. elegans let-7 being identical to human let-7a; let-7 is generally believed to be a tumor suppressor miRNA, as expression of let-7 family members are down-regulated in many cancers, including lung, breast, ovarian, and prostate cancers, and melanoma, when compared to normal tissues; however upregulation of certain let-7 family members has been observed in a few cancers, indicating that let-7 may not play a tumor suppressor role in all tissues/circumstances; human let-7 targets several cancer-relevant targets for repression including: the RAS/let-60 gene (upregulated in lung cancers), HMGA2, a chromatin-associated non-histone protein, IGF2 mRNA binding protein (IMP1), and lin28B; studies in elegans indicate that let-7 and let-7 miRNA family members and their target genes regulate the expression of the amyloid precursor protein-like, apl-1, (orthologous to human APP), which may provide insights into the progression of Alzheimer''s disease. Homo sapiens Paper_evidence: WBPaper00035291
            WBPaper00031506
          Curator_confirmed: WBPerson324
          Date_last_updated: 18 Dec 2013 00:00:00
  Models_disease_in_annotation: WBDOannot00000256
  Molecular_info: Corresponding_transcript: C05G5.6
      C05G5.6.1
      C05G5.6.2
      C05G5.6.3
      C05G5.6a
      C05G5.6b
    Corresponding_transcript_history: C05G5.6:wp135
    Associated_feature: WBsf718850
      WBsf979137
      WBsf1007993
    Gene_product_binds (20)
  Experimental_info: Expr_pattern (20)
    Drives_construct (16)
    Construct_product (28)
    Regulate_expr_cluster: WBPaper00042165:let-7_downregulated
      WBPaper00042165:let-7_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00050717:let-7(n2853)_lin-41(xe11)_downregulated
      WBPaper00050717:let-7(n2853)_lin-41(xe11)_upregulated
      WBPaper00064080:let-7_miRNA_interacting
    Expression_cluster (39)
    Interaction (449)
    WBProcess: WBbiopr:00000020
      WBbiopr:00000057
      WBbiopr:00000081
      WBbiopr:00000083
  Map_info: Map: X Position: 21.2192 Error: 0.067046
    Well_ordered
    Positive: Positive_clone: C05G5 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 192
      Multi_point: 188
        4742
      Pos_neg_data: 2068
        2096
        2200
        2205
        2212
        2218
        2224
        2275
        2279
  Reference (475)
  Remark: Sequence connection from [Reinhart BJ, Slack FJ]
    Rfam accession number: MI0000001
  Method: Gene