WormBase Tree Display for Gene: WBGene00002247
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| WBGene00002247 | SMap | S_parent | Sequence | W03F8 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | lam-1 | Person_evidence | WBPerson1052 | |||||
| Sequence_name | W03F8.5 | ||||||||
| Molecular_name | W03F8.5a | ||||||||
| W03F8.5a.1 | |||||||||
| CE47338 | |||||||||
| W03F8.5b | |||||||||
| CE49160 | |||||||||
| W03F8.5b.1 | |||||||||
| Other_name | LAMB/1 | ||||||||
| CELE_W03F8.5 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | lam-1 | ||||||||
| DB_info | Database | AceView | gene | 4F943 | |||||
| WormQTL | gene | WBGene00002247 | |||||||
| WormFlux | gene | WBGene00002247 | |||||||
| NDB | locus_tag | CELE_W03F8.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00002247|UniProtKB=O44565 | |||||||
| family | PTHR10574 | ||||||||
| NCBI | gene | 177292 | |||||||
| RefSeq | protein | NM_068333.6 | |||||||
| NM_001380214.1 | |||||||||
| TrEMBL | UniProtAcc | V6CIX7 | |||||||
| O44565 | |||||||||
| UniProt_GCRP | UniProtAcc | O44565 | |||||||
| OMIM | gene | 150240 | |||||||
| 150310 | |||||||||
| 150325 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:27 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 30 Jan 2012 16:23:16 | WBPerson1867 | Event | Acquires_merge | WBGene00020998 | ||||
| Acquires_merge | WBGene00020998 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lam | ||||||||
| Allele (90) | |||||||||
| Legacy_information | [C.elegansII] rh219 : resembles Epi-1, basal lamina missing or defective in epidermis, gonad, intestine;abnormal excretory canals, muscle cell positions, sheath cells, proximal gonad, basement membranes, ray morphology. rh219/Df is larval lethal. Cloned: rescued by cosmid C24D10, encodes lamininbeta chain. [NJ] | ||||||||
| Strain | WBStrain00037319 | ||||||||
| WBStrain00037470 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00032878 | ||||||||
| 00032879 | |||||||||
| 00032880 | |||||||||
| 00032881 | |||||||||
| 00032882 | |||||||||
| 00032883 | |||||||||
| 00032884 | |||||||||
| 00032885 | |||||||||
| 00032886 | |||||||||
| Contained_in_operon | CEOP4156 | ||||||||
| Ortholog (53) | |||||||||
| Paralog | WBGene00001328 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00006787 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00002248 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00018304 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006432 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00006746 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00016913 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00020581 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | lam-1 encodes a laminin beta that affects degenerin-induced cell death and is required redundantly with lam-2 for morphogenesis. | Paper_evidence | WBPaper00015206 | |||||
| WBPaper00023289 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Involved in pharynx development and positive regulation of locomotion. Located in basement membrane. Expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including Pierson syndrome; amelogenesis imperfecta type 1A; and lung carcinoma (multiple). Is an ortholog of human LAMB1 (laminin subunit beta 1) and LAMB2 (laminin subunit beta 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:5409 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6490) | ||||
| DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6490) | ||||||
| DOID:0080380 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6487) | ||||||
| DOID:1070 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6487) | ||||||
| DOID:12849 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6486) | ||||||
| DOID:3209 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6490) | ||||||
| DOID:0110054 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6490) | ||||||
| DOID:0112230 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6486) | ||||||
| DOID:0060852 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6487) | ||||||
| Molecular_info | Corresponding_CDS | W03F8.5a | |||||||
| W03F8.5b | |||||||||
| Corresponding_CDS_history | W03F8.5:wp101 | ||||||||
| W03F8.5:wp230 | |||||||||
| Corresponding_transcript | W03F8.5a.1 | ||||||||
| W03F8.5b.1 | |||||||||
| Other_sequence (45) | |||||||||
| Associated_feature (11) | |||||||||
| Experimental_info | RNAi_result (20) | ||||||||
| Expr_pattern | Expr3984 | ||||||||
| Expr10827 | |||||||||
| Expr1019727 | |||||||||
| Expr1031321 | |||||||||
| Expr1158236 | |||||||||
| Expr1158240 | |||||||||
| Expr2013007 | |||||||||
| Expr2031239 | |||||||||
| Drives_construct | WBCnstr00005458 | ||||||||
| WBCnstr00005751 | |||||||||
| WBCnstr00006684 | |||||||||
| WBCnstr00008702 | |||||||||
| WBCnstr00008703 | |||||||||
| WBCnstr00008704 | |||||||||
| WBCnstr00008752 | |||||||||
| WBCnstr00022483 | |||||||||
| WBCnstr00024738 | |||||||||
| Construct_product | WBCnstr00005458 | ||||||||
| WBCnstr00005751 | |||||||||
| WBCnstr00008752 | |||||||||
| WBCnstr00017755 | |||||||||
| WBCnstr00022483 | |||||||||
| WBCnstr00022851 | |||||||||
| WBCnstr00024738 | |||||||||
| Microarray_results (37) | |||||||||
| Expression_cluster (203) | |||||||||
| Interaction (39) | |||||||||
| Anatomy_function | WBbtf0735 | ||||||||
| WBbtf0736 | |||||||||
| Map_info | Map | IV | Position | 1.55302 | Error | 0.001128 | |||
| Positive | Positive_clone (3) | ||||||||
| Mapping_data | Multi_point | 4471 | |||||||
| 5450 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (28) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
