WormBase Tree Display for Gene: WBGene00001993
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WBGene00001993 | Evidence | CGC_data_submission | |||||||
---|---|---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | T21C12 | ||||||
Identity | Version | 1 | |||||||
Name | CGC_name | hpd-1 | Person_evidence | WBPerson545 | |||||
Sequence_name | T21C12.2 | ||||||||
Molecular_name | T21C12.2 | ||||||||
T21C12.2.1 | |||||||||
CE02347 | |||||||||
Other_name | CELE_T21C12.2 | Accession_evidence | NDB | BX284603 | |||||
Public_name | hpd-1 | ||||||||
DB_info | Database (13) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:26 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | hpd | ||||||||
Allele (40) | |||||||||
Legacy_information | RNAi of hpd-1 modestly extends C. elegans lifespan, and weakly inhibits dauer recovery of daf-2(e1370) at 22C. | Person_evidence | WBPerson3621 | ||||||
Strain | WBStrain00036676 | ||||||||
Component_of_genotype | WBGenotype00000123 | ||||||||
WBGenotype00000125 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (17) | |||||||||
Ortholog (38) | |||||||||
Paralog | WBGene00016294 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
Panther | |||||||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | hpd-1 encodes a putative 4-hydroxyphenylpyruvate dioxygenase requiredfor normally short lifespan and for negative regulation of the dauer larval stage, with loss of hpd-1 function prolonging lifespan andpromoting dauer formation; hpd-1 is a (perhaps evolutionarily conserved)target of transcriptional activation by DAF-16; HPD-1 is orthologous tohuman HPD (OMIM:609695, mutated in tyrosinemia type III), and isparalogous to C31H2.4 and human HPDL/GLOXD1; HPD-1 is expressed inhypodermis and intestine, and is required for the tyrosinemic phenotypeof K10C2.4(RNAi) animals. | Paper_evidence | WBPaper00005813 | |||||
WBPaper00006525 | |||||||||
WBPaper00031006 | |||||||||
WBPaper00031468 | |||||||||
Curator_confirmed | WBPerson1823 | ||||||||
WBPerson567 | |||||||||
Date_last_updated | 02 Mar 2008 00:00:00 | ||||||||
Automated_description | Predicted to enable 4-hydroxyphenylpyruvate dioxygenase activity. Predicted to be involved in tyrosine catabolic process. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hawkinsinuria and tyrosinemia type III. Is an ortholog of human HPD (4-hydroxyphenylpyruvate dioxygenase). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:0111362 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5147) | ||||
DOID:0050727 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:5147) | ||||||
Molecular_info | Corresponding_CDS | T21C12.2 | |||||||
Corresponding_transcript | T21C12.2.1 | ||||||||
Other_sequence (379) | |||||||||
Associated_feature | WBsf654990 | ||||||||
WBsf654991 | |||||||||
WBsf981567 | |||||||||
WBsf994063 | |||||||||
WBsf994064 | |||||||||
WBsf1015811 | |||||||||
Experimental_info | RNAi_result (12) | ||||||||
Expr_pattern (8) | |||||||||
Drives_construct | WBCnstr00003270 | ||||||||
WBCnstr00036534 | |||||||||
Construct_product | WBCnstr00036534 | ||||||||
Microarray_results (22) | |||||||||
Expression_cluster (244) | |||||||||
Interaction (26) | |||||||||
Map_info | Map | III | Position | 3.48495 | Error | 0.062473 | |||
Positive | Positive_clone | T21C12 | Inferred_automatically | From CDS info | |||||
From sequence, transcript, pseudogene data | |||||||||
Pseudo_map_position | |||||||||
Reference | WBPaper00005813 | ||||||||
WBPaper00031468 | |||||||||
WBPaper00034325 | |||||||||
WBPaper00038491 | |||||||||
WBPaper00038936 | |||||||||
WBPaper00049828 | |||||||||
WBPaper00055090 | |||||||||
WBPaper00065140 | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |